2020
The B cell immunobiology that underlies CNS autoantibody-mediated diseases
Sun B, Ramberger M, O’Connor K, Bashford-Rogers RJM, Irani SR. The B cell immunobiology that underlies CNS autoantibody-mediated diseases. Nature Reviews Neurology 2020, 16: 481-492. PMID: 32724223, PMCID: PMC9364389, DOI: 10.1038/s41582-020-0381-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoantigensAutoimmune DiseasesB-LymphocytesCentral Nervous System DiseasesHumansImmunotherapyConceptsAutoantigen-specific B cellsB cellsPathogenic autoantibodiesB cell tolerance checkpointsAutoantibody-mediated diseasesB cell immunobiologyLong-term morbidityHigher serum levelsCirculation of patientsSource of autoantibodiesSite of pathologyB-cell lineageClinical relapseAvailable medicationsSerum levelsIntrathecal synthesisCNS diseaseTolerance checkpointsPlasma cellsTherapeutic effectCerebrospinal fluidGerminal centersAutoantibodiesDiseasePatients
2019
Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity
Stathopoulos P, Chastre A, Waters P, Irani S, Fichtner ML, Benotti ES, Guthridge JM, Seifert J, Nowak RJ, Buckner JH, Holers VM, James JA, Hafler DA, O’Connor K. Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity. The Journal Of Immunology 2019, 202: ji1801295. PMID: 30824481, PMCID: PMC6452031, DOI: 10.4049/jimmunol.1801295.Peer-Reviewed Original ResearchMeSH KeywordsAutoantibodiesAutoantigensAutoimmune DiseasesB-LymphocytesFemaleHEK293 CellsHumansMaleMiddle AgedNerve Tissue ProteinsConceptsSystemic lupus erythematosusRheumatoid arthritisControl cohortNeuromyelitis optica spectrum disorderSurface AgOptica spectrum disorderMyelin oligodendrocyte glycoproteinHealthy donor seraType 1 diabetesB cell toleranceNeurologic autoimmunitySLE patientsLupus erythematosusSuch autoantibodiesT1D patientsAutoimmune diseasesHigh titer AbsOligodendrocyte glycoproteinSystemic autoimmunityDonor seraLarge cohortRare caseAutoantibodiesAquaporin-4Cell tolerance
2016
Chapter 27 Current and future immunotherapy targets in autoimmune neurology
Hu MY, Stathopoulos P, O’connor K, Pittock SJ, Nowak RJ. Chapter 27 Current and future immunotherapy targets in autoimmune neurology. Handbook Of Clinical Neurology 2016, 133: 511-536. PMID: 27112694, DOI: 10.1016/b978-0-444-63432-0.00027-x.ChaptersConceptsAutoimmune neurologic disordersNeurologic disordersChronic inflammatory demyelinating polyradiculoneuropathyInflammatory demyelinating polyradiculoneuropathyPrior treatment responseLarge case seriesAbsence of cancerAutoimmune neurologyChronic immunotherapyDemyelinating polyradiculoneuropathyMyasthenia gravisNeuromyelitis opticaCase seriesOncologic therapyTreatment trialsImmunotherapy targetClinical severityTreatment strategiesTreatment responseAntibody typeMonoclonal antibodiesAnecdotal reportsNew drug discoveryDisordersImmunotherapy