2023
Brain Health Indicators Following Acute Neuro-Exergaming: Biomarker and Cognition in Mild Cognitive Impairment (MCI) after Pedal-n-Play (iPACES)
Nath K, Ferguson I, Puleio A, Wall K, Stark J, Clark S, Story C, Cohen B, Anderson-Hanley C. Brain Health Indicators Following Acute Neuro-Exergaming: Biomarker and Cognition in Mild Cognitive Impairment (MCI) after Pedal-n-Play (iPACES). Brain Sciences 2023, 13: 844. PMID: 37371324, PMCID: PMC10296731, DOI: 10.3390/brainsci13060844.Peer-Reviewed Original ResearchMild cognitive impairmentExecutive functionOlder adultsCognitive impairmentCognitive exercisesSignificant interaction effectCognitive effectsNon-pharmacological wayMCI participantsAlpha-amylase levelsCognitive declineRepeated-measures ANOVAVideo gamesDementia casesSingle boutBiomarker outcomesLater lifeSalivary assessmentsInteraction effectsPotential mechanismsHealth indicatorsParticipantsAdultsImpairmentGroup changes
2018
The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers
Anderson-Hanley C, Stark J, Wall KM, VanBrakle M, Michel M, Maloney M, Barcelos N, Striegnitz K, Cohen BD, Kramer AF. The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers. Clinical Interventions In Aging 2018, 13: 1565-1577. PMID: 30233154, PMCID: PMC6130272, DOI: 10.2147/cia.s160756.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentOlder adultsCognitive impairmentVerbal memoryExecutive functionNeurobiological outcomesNeuropsychological functionNeurobiological mechanismsCognitive functionMental exerciseHealthy agingPilot clinical trialBiomarker measuresClinical trialsPilot dataAdultsSalivary biomarkersImpairmentCognitionFurther researchMemoryPosttrialInadequate dosePreliminary indicationParticipants