2023
Brain Health Indicators Following Acute Neuro-Exergaming: Biomarker and Cognition in Mild Cognitive Impairment (MCI) after Pedal-n-Play (iPACES)
Nath K, Ferguson I, Puleio A, Wall K, Stark J, Clark S, Story C, Cohen B, Anderson-Hanley C. Brain Health Indicators Following Acute Neuro-Exergaming: Biomarker and Cognition in Mild Cognitive Impairment (MCI) after Pedal-n-Play (iPACES). Brain Sciences 2023, 13: 844. PMID: 37371324, PMCID: PMC10296731, DOI: 10.3390/brainsci13060844.Peer-Reviewed Original ResearchMild cognitive impairmentExecutive functionOlder adultsCognitive impairmentCognitive exercisesSignificant interaction effectCognitive effectsNon-pharmacological wayMCI participantsAlpha-amylase levelsCognitive declineRepeated-measures ANOVAVideo gamesDementia casesSingle boutBiomarker outcomesLater lifeSalivary assessmentsInteraction effectsPotential mechanismsHealth indicatorsParticipantsAdultsImpairmentGroup changes
2018
The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers
Anderson-Hanley C, Stark J, Wall KM, VanBrakle M, Michel M, Maloney M, Barcelos N, Striegnitz K, Cohen BD, Kramer AF. The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers. Clinical Interventions In Aging 2018, 13: 1565-1577. PMID: 30233154, PMCID: PMC6130272, DOI: 10.2147/cia.s160756.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentOlder adultsCognitive impairmentVerbal memoryExecutive functionNeurobiological outcomesNeuropsychological functionNeurobiological mechanismsCognitive functionMental exerciseHealthy agingPilot clinical trialBiomarker measuresClinical trialsPilot dataAdultsSalivary biomarkersImpairmentCognitionFurther researchMemoryPosttrialInadequate dosePreliminary indicationParticipantsThe Enhanced Interactive Physical and Cognitive Exercise System (iPACESTM v2.0): Pilot Clinical Trial of an In-Home iPad-Based Neuro-Exergame for Mild Cognitive Impairment (MCI)
Wall K, Stark J, Schillaci A, Saulnier ET, McLaren E, Striegnitz K, Cohen BD, Arciero PJ, Kramer AF, Anderson-Hanley C. The Enhanced Interactive Physical and Cognitive Exercise System (iPACESTM v2.0): Pilot Clinical Trial of an In-Home iPad-Based Neuro-Exergame for Mild Cognitive Impairment (MCI). Journal Of Clinical Medicine 2018, 7: 249. PMID: 30200183, PMCID: PMC6162846, DOI: 10.3390/jcm7090249.Peer-Reviewed Original ResearchBiomarkers and components of the interactive Physical and Cognitive Exercise System (iPACES™ v2.0) for Mild Cognitive Impairment (MCI): Cortisol, Dehydroepiandrosterone (DHEA‐S), and Insulin‐like Growth Factor (IGF1)
Wall K, Stark J, Karla‐Lall A, Schillaci A, Christian H, Doty C, McLaren E, Saulnier T, Cohen B, Anderson‐Hanley C. Biomarkers and components of the interactive Physical and Cognitive Exercise System (iPACES™ v2.0) for Mild Cognitive Impairment (MCI): Cortisol, Dehydroepiandrosterone (DHEA‐S), and Insulin‐like Growth Factor (IGF1). The FASEB Journal 2018, 32: 588.25-588.25. DOI: 10.1096/fasebj.2018.32.1_supplement.588.25.Peer-Reviewed Original ResearchMild cognitive impairmentCognitive outcomesCognitive impairmentSignificant cognitive improvementCognitive trainingCognitive interventionsCognitive abilitiesExecutive functionFlanker testCognitive improvementNeurobiological mechanismsSubjects designGame interventionCognitive declineOlder adultsEfficacious interventionsPrior researchStroopSuch interventions