2023
Brain Health Indicators Following Acute Neuro-Exergaming: Biomarker and Cognition in Mild Cognitive Impairment (MCI) after Pedal-n-Play (iPACES)
Nath K, Ferguson I, Puleio A, Wall K, Stark J, Clark S, Story C, Cohen B, Anderson-Hanley C. Brain Health Indicators Following Acute Neuro-Exergaming: Biomarker and Cognition in Mild Cognitive Impairment (MCI) after Pedal-n-Play (iPACES). Brain Sciences 2023, 13: 844. PMID: 37371324, PMCID: PMC10296731, DOI: 10.3390/brainsci13060844.Peer-Reviewed Original ResearchMild cognitive impairmentExecutive functionOlder adultsCognitive impairmentCognitive exercisesSignificant interaction effectCognitive effectsNon-pharmacological wayMCI participantsAlpha-amylase levelsCognitive declineRepeated-measures ANOVAVideo gamesDementia casesSingle boutBiomarker outcomesLater lifeSalivary assessmentsInteraction effectsPotential mechanismsHealth indicatorsParticipantsAdultsImpairmentGroup changes
2018
NEURO-EXERGAME: PILOT CLINICAL TRIAL OF AN IN-HOME INTERVENTION FOR MILD COGNITIVE IMPAIRMENT (IPACESV2.0)
Wall K, Stark J, Schillaci A, Saulnier E, McLaren E, Cohen B, Arciero P, Anderson-Hanley C. NEURO-EXERGAME: PILOT CLINICAL TRIAL OF AN IN-HOME INTERVENTION FOR MILD COGNITIVE IMPAIRMENT (IPACESV2.0). Innovation In Aging 2018, 2: 984-985. PMCID: PMC6239807, DOI: 10.1093/geroni/igy031.3642.Peer-Reviewed Original ResearchMild cognitive impairmentEnzyme-linked immunosorbent assayCognitive impairmentCognitive declinePilot clinical trialThree-month interventionExecutive functionTreat analysisDementia casesBiomarker levelsClinical trialsIGF-1Improved cognitionEfficacious interventionsPhysical exerciseSalivary biomarkersHome interventionSaliva samplesImmunosorbent assayCognitive outcomesWeek intervalsPilot dataThe interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers
Anderson-Hanley C, Stark J, Wall KM, VanBrakle M, Michel M, Maloney M, Barcelos N, Striegnitz K, Cohen BD, Kramer AF. The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers. Clinical Interventions In Aging 2018, 13: 1565-1577. PMID: 30233154, PMCID: PMC6130272, DOI: 10.2147/cia.s160756.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentOlder adultsCognitive impairmentVerbal memoryExecutive functionNeurobiological outcomesNeuropsychological functionNeurobiological mechanismsCognitive functionMental exerciseHealthy agingPilot clinical trialBiomarker measuresClinical trialsPilot dataAdultsSalivary biomarkersImpairmentCognitionFurther researchMemoryPosttrialInadequate dosePreliminary indicationParticipantsBiomarkers and components of the interactive Physical and Cognitive Exercise System (iPACES™ v2.0) for Mild Cognitive Impairment (MCI): Cortisol, Dehydroepiandrosterone (DHEA‐S), and Insulin‐like Growth Factor (IGF1)
Wall K, Stark J, Karla‐Lall A, Schillaci A, Christian H, Doty C, McLaren E, Saulnier T, Cohen B, Anderson‐Hanley C. Biomarkers and components of the interactive Physical and Cognitive Exercise System (iPACES™ v2.0) for Mild Cognitive Impairment (MCI): Cortisol, Dehydroepiandrosterone (DHEA‐S), and Insulin‐like Growth Factor (IGF1). The FASEB Journal 2018, 32: 588.25-588.25. DOI: 10.1096/fasebj.2018.32.1_supplement.588.25.Peer-Reviewed Original ResearchMild cognitive impairmentCognitive outcomesCognitive impairmentSignificant cognitive improvementCognitive trainingCognitive interventionsCognitive abilitiesExecutive functionFlanker testCognitive improvementNeurobiological mechanismsSubjects designGame interventionCognitive declineOlder adultsEfficacious interventionsPrior researchStroopSuch interventions