2019
Fold-Change Detection of NF-κB at Target Genes with Different Transcript Outputs
Wong VC, Mathew S, Ramji R, Gaudet S, Miller-Jensen K. Fold-Change Detection of NF-κB at Target Genes with Different Transcript Outputs. Biophysical Journal 2019, 116: 709-724. PMID: 30704857, PMCID: PMC6382958, DOI: 10.1016/j.bpj.2019.01.011.Peer-Reviewed Original ResearchConceptsFold-change detectionTarget genesTranscript outputStress-responsive gene transcriptionSingle-cell dataNF-κB target genesRelA nuclear translocationLive-cell imagingMicrofluidic cell-trapping deviceLow-abundance transcriptsTranscription factor nuclear factorNF-κBRNA FISHTranscriptional outputΚB motifTranscript abundanceGene transcriptionTranscriptionTranscript numbersCell trap deviceJurkat TCell typesGenesNF-κB signalingMultiple biological mechanisms
2015
Distinct promoter activation mechanisms modulate noise-driven HIV gene expression
Chavali AK, Wong VC, Miller-Jensen K. Distinct promoter activation mechanisms modulate noise-driven HIV gene expression. Scientific Reports 2015, 5: 17661. PMID: 26666681, PMCID: PMC4678399, DOI: 10.1038/srep17661.Peer-Reviewed Original Research
2007
Common effector processing mediates cell-specific responses to stimuli
Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA. Common effector processing mediates cell-specific responses to stimuli. Nature 2007, 448: 604-608. PMID: 17637676, DOI: 10.1038/nature06001.Peer-Reviewed Original ResearchConceptsDistinct epithelial cell linesCell type-specific signalsCell type-specific outcomesCell specificityCell-specific responsesDifferent cell typesOrganismal homeostasisEmbryonic developmentEpithelial cell lineCommon effectorCell typesSpecific signalsMost cellsCell linesOrganismsEffectorsHomeostasisPathwaySpecificityCellsTherapeuticsEnigma