Discrimination of the Veterans Aging Cohort Study Index 2.0 for Predicting Cause-specific Mortality Among Persons With HIV in Europe and North America
Ambia J, Ingle S, McGinnis K, Pantazis N, Silverberg M, Wittkop L, Kusejko K, Crane H, van Sighem A, Sarcletti M, Cozzi-Lepri A, Domingo P, Jarrin I, Wyen C, Hessamfar M, Zhang L, Cavassini M, Berenguer J, Sterling T, Reiss P, Abgrall S, Gill M, Justice A, Sterne J, Trickey A. Discrimination of the Veterans Aging Cohort Study Index 2.0 for Predicting Cause-specific Mortality Among Persons With HIV in Europe and North America. Open Forum Infectious Diseases 2024, 11: ofae333. PMID: 39015347, PMCID: PMC11249920, DOI: 10.1093/ofid/ofae333.Peer-Reviewed Original ResearchVeterans Aging Cohort StudyVeterans Aging Cohort Study IndexCause-specific mortalityNon-AIDS-defining cancersNon-AIDS-definingPredicting cause-specific mortalityFlexible parametric survival modelsAntiretroviral therapyC-statisticNon-AIDS infectionsAging Cohort StudyAbsolute mortality riskHarrell's C-statisticAntiretroviral therapy initiationParametric survival modelsTargeted careCause of deathMortality riskVisit dateMultiple imputationCohort studyPWHAssess discriminationCox modelRespiratory-relatedLongitudinal trends in causes of death among adults with HIV on antiretroviral therapy in Europe and North America from 1996 to 2020: a collaboration of cohort studies
Trickey A, McGinnis K, Gill M, Abgrall S, Berenguer J, Wyen C, Hessamfar M, Reiss P, Kusejko K, Silverberg M, Imaz A, Teira R, d'Arminio Monforte A, Zangerle R, Guest J, Papastamopoulos V, Crane H, Sterling T, Grabar S, Ingle S, Sterne J. Longitudinal trends in causes of death among adults with HIV on antiretroviral therapy in Europe and North America from 1996 to 2020: a collaboration of cohort studies. The Lancet HIV 2024, 11: e176-e185. PMID: 38280393, DOI: 10.1016/s2352-3018(23)00272-2.Peer-Reviewed Original ResearchConceptsCause-specific mortalityAvailability of effective antiretroviral therapyAll-cause mortalityRates of all-cause mortalityPatterns of cause-specific mortalityCause-specific mortality ratesCohort studyAdjusted mortality rate ratiosAntiretroviral Therapy Cohort CollaborationMortality rate ratiosInternational Classification of DiseasesMortality rateLongitudinal trendsAccident-related mortalityRates of cause-specific mortalityProportion of deathsClassification of DiseasesAIDS-related mortalityAIDS-related deathsAntiretroviral therapyInvestigate longitudinal trendsIncreased life expectancyInjection drug useHIV ageObservational cohort study