1997
Parathyroid Hormone Increases Circulating Levels of Fibronectin in Vivo: Modulating Effect of Ovariectomy*
Sun B, Mitnick M, Eielson C, Yao G, Paliwal I, Insogna K. Parathyroid Hormone Increases Circulating Levels of Fibronectin in Vivo: Modulating Effect of Ovariectomy*. Endocrinology 1997, 138: 3918-3924. DOI: 10.1210/en.138.9.3918.Peer-Reviewed Original ResearchResponse to PTHEffect of PTHHuman PTHCirculating levelsLevels of FNFN in vivoCultured fetal rat bonesAdult female Sprague-Dawley ratsFemale Sprague-Dawley ratsTreated with PTHVehicle infused groupFN productionEstrogen-deficient stateFetal rat bonesSignificant 2.4-fold increaseBlock bone resorptionSprague-Dawley ratsROS 17/2.8 cellsIn vitro studiesBisphosphonate APDEstrogen deficiencyAlzet minipumpsEstrogen withdrawalLevels in vivoBlunted responseParathyroid Hormone Increases Circulating Levels of Fibronectin in Vivo: Modulating Effect of Ovariectomy
Sun B, Mitnick M, Eielson C, Yao G, Paliwal I, Insogna K. Parathyroid Hormone Increases Circulating Levels of Fibronectin in Vivo: Modulating Effect of Ovariectomy. Endocrinology 1997, 138: 3918-3924. PMID: 9275082, DOI: 10.1210/endo.138.9.5421.Peer-Reviewed Original ResearchConceptsLevels of fibronectinEffect of PTHAbility of PTHHuman PTHAdult female Sprague-Dawley ratsFemale Sprague-Dawley ratsCultured fetal rat bonesDiminished bone formationEstrogen-deficient stateHuman PTH-(1-34) infusionSprague-Dawley ratsFN productionFetal rat boneBisphosphonate APDHPTH groupPTH infusionCirculating LevelsAlzet minipumpsEstrogen deficiencyParathyroid hormoneEstrogen withdrawalBone resorptionAnabolic propertiesROS 17/2.8 cellsEffective agonist
1993
Macrophage colony‐stimulating factor release and receptor expression in bone cells
Weir E, Horowitz M, Baron R, Centrella M, Kacinski B, Insogna K. Macrophage colony‐stimulating factor release and receptor expression in bone cells. Journal Of Bone And Mineral Research 1993, 8: 1507-1518. PMID: 8304053, DOI: 10.1002/jbmr.5650081214.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone MarrowBone Marrow CellsCell DivisionCells, CulturedColony-Forming Units AssayCulture Media, ConditionedGranulocyte-Macrophage Colony-Stimulating FactorMacrophage Colony-Stimulating FactorMacrophagesMaleOsteoblastsOsteoclastsParathyroid HormoneParathyroid Hormone-Related ProteinProteinsRatsRats, Sprague-DawleyRats, WistarReceptor, Macrophage Colony-Stimulating FactorTumor Cells, CulturedConceptsColony-stimulating factorColony-stimulating activityM-CSFBone resorptionReceptor expressionMature osteoclastsPreincubation of CMColony-stimulating factor releaseHormone-related peptideM-CSF receptor c-FmsMacrophage colony-stimulating factorOsteoblast-osteoclast interactionsM-CSF mRNA levelsBone marrow cellsCSF-1 receptor expressionRat bone marrow cellsReceptor c-fmsROS 17/2.8 cellsParacrine roleImmunohistochemical techniquesRat osteoblastsPTHrP treatmentMarrow cellsFactor releasePTH
1983
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Rodan SB, Insogna KL, Vignery AM, Stewart AF, Broadus AE, D'Souza SM, Bertolini DR, Mundy GR, Rodan GA. Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. Journal Of Clinical Investigation 1983, 72: 1511-1515. PMID: 6685137, PMCID: PMC370436, DOI: 10.1172/jci111108.Peer-Reviewed Original ResearchConceptsHumoral hypercalcemiaAdenylate cyclaseBone resorbing activityBone resorptive activityLeydig cell tumorCyclic AMP accumulationHuman prostate carcinomaRat Leydig cell tumorAdenylate cyclase stimulationSolid human tumorsNormocalcemic patientsOsteoblastic cellsResorbing activityCell tumorsLung adenocarcinomaProstate carcinomaROS 17/2.8 cellsAMP accumulationResorptive activityCyclase stimulationTumorsHuman tumorsStimulationHypercalcemiaRat carcinosarcoma