2017
Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation 1 , 2
Shams-White MM, Chung M, Du M, Fu Z, Insogna KL, Karlsen MC, LeBoff MS, Shapses SA, Sackey J, Wallace TC, Weaver CM. Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation 1 , 2. American Journal Of Clinical Nutrition 2017, 105: 1528-1543. PMID: 28404575, DOI: 10.3945/ajcn.116.145110.Peer-Reviewed Original ResearchConceptsBone mineral densityHigh protein intakeProspective cohort studyProtein intakeSystematic reviewCohort studyBone healthTotal hipFemoral neckModerate evidenceLumbar spine bone mineral densityTotal body bone mineral densityTH bone mineral densityLS bone mineral densityBody bone mineral densitySpine bone mineral densityFN bone mineral densityBone health measuresBone health outcomesDietary proteinLow protein intakeFull-text screeningStrength of evidenceOverall RoBNonpharmacologic approachesANIMAL VERSUS PLANT PROTEIN INTAKE AND BONE HEALTH‐A SYSTEMATIC REVIEW AND META‐ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Shams‐White M, Fu Z, Karlsen M, Sackey J, Shi J, Insogna K, LeBoff M, Shapses S, Weaver C, Wallace T, Chung M. ANIMAL VERSUS PLANT PROTEIN INTAKE AND BONE HEALTH‐A SYSTEMATIC REVIEW AND META‐ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.139.3.Peer-Reviewed Original ResearchBone-specific alkaline phosphataseBone mineral densityPlant protein intakeBone mineral contentRandomized controlled trialsPost-menopausal womenProtein intakeLumbar spineTotal bodyFemoral neckCollagen type 1 cross-linked C-telopeptideCross-linked C-telopeptideBone mineral density outcomesTotal hipCross-linked N-telopeptideMeta-analysis of randomized controlled trialsTB bone mineral contentControlled trialsSystematic reviewLow statistical heterogeneityMeta-analysisBone health outcomesHealthy adultsRandom-effects meta-analysesEffects meta-analyses
2016
Protein Intake and Bone Mineral Density‐ a Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Shams‐White M, Sackey J, Fu Z, Karlsen M, Du M, Insogna K, LeBoff M, Shapses S, Weaver C, Chung M. Protein Intake and Bone Mineral Density‐ a Systematic Review and Meta‐Analysis of Randomized Controlled Trials. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.678.6.Peer-Reviewed Original ResearchBone mineral densityRisk of bias assessmentRandomized controlled trialsProtein intakeMeta-analysis resultsSystematic reviewBMD lossBias assessmentMeta-analysisFemoral neck bone mineral densityBone mineral density siteBone mineral density outcomesNeck bone mineral densityTotal hipMeta-analysis of randomized controlled trialsControlled trialsSpine BMD lossRandom-effects meta-analysesPlant protein intakeFull-text screeningPost-menopausal womenHealthy adultsAttenuating BMD lossEffects meta-analysesHigher protein intake
2015
Dietary Protein and Vitamin D Intake and Risk of Falls: A Secondary Analysis of Postmenopausal Women from the Study of Osteoporotic Fractures
Larocque SC, Kerstetter JE, Cauley JA, Insogna KL, Ensrud K, Lui LY, Allore HG. Dietary Protein and Vitamin D Intake and Risk of Falls: A Secondary Analysis of Postmenopausal Women from the Study of Osteoporotic Fractures. Journal Of Nutrition In Gerontology And Geriatrics 2015, 34: 305-318. PMID: 26267443, PMCID: PMC4547350, DOI: 10.1080/21551197.2015.1054574.Peer-Reviewed Original ResearchConceptsVitamin D intakeVitamin DD intakePostmenopausal womenOsteoporotic fracturesDietary proteinOdds ratioOlder adultsFood frequency questionnaireRisk of fallsOccurrence of fallsIncident fallsFrequency questionnaireProspective cohortHip fractureMusculoskeletal healthInadequate intakeAdequate intakeOlder womenProtein intakeMuscle massSecondary analysisLogistic regressionIntakeWomenThe effects of dietary protein and amino acids on skeletal metabolism
Bihuniak JD, Insogna KL. The effects of dietary protein and amino acids on skeletal metabolism. Molecular And Cellular Endocrinology 2015, 410: 78-86. PMID: 25843057, PMCID: PMC5852680, DOI: 10.1016/j.mce.2015.03.024.BooksConceptsDietary proteinDietary protein intakeOptimal skeletal growthRecent data bearingSkeletal healthCalcium economyMineral metabolismSkeletal metabolismProtein intakeDietary allowanceSkeletal homeostasisNutrient intakeSkeletal massIntakeSkeletal growthSite-specific effectsMolecular mechanismsMetabolismVariable levelsLife continuumProtein
2013
The effect of selective amino acid supplementation on calcium absorption during a low protein diet
Bihuniak J, Sullivan R, Simpson C, Caseria D, O'Brien K, Kerstetter J, Insogna K. The effect of selective amino acid supplementation on calcium absorption during a low protein diet. The FASEB Journal 2013, 27: lb283-lb283. DOI: 10.1096/fasebj.27.1_supplement.lb283.Peer-Reviewed Original ResearchLow-protein dietIntestinal Ca absorptionCa absorptionProtein dietProtein intakeDietary protein intakeHigh-protein dietAmino acid supplementationCalcium absorptionAcid supplementationDay 5Dibasic amino acidsAA supplementationYoung womenControl dietRandom orderPhysiologic rangeDietary proteinIntakeDietSupplementationAmino acidsAromatic amino acidsCa economyLys supplementationDietary Protein-Induced Increases in Urinary Calcium Are Accompanied by Similar Increases in Urinary Nitrogen and Urinary Urea: A Controlled Clinical Trial
Bihuniak JD, Simpson CA, Sullivan RR, Caseria DM, Kerstetter JE, Insogna KL. Dietary Protein-Induced Increases in Urinary Calcium Are Accompanied by Similar Increases in Urinary Nitrogen and Urinary Urea: A Controlled Clinical Trial. Journal Of The Academy Of Nutrition And Dietetics 2013, 113: 447-451. PMID: 23438496, PMCID: PMC5868414, DOI: 10.1016/j.jand.2012.11.002.Peer-Reviewed Original ResearchConceptsBone turnover markersDietary protein intakeUrinary creatinineUrinary calciumProtein intakeUrinary ureaTurnover markersUrinary nitrogenNutrition intervention trialMaltodextrin controlPostmenopausal womenIntervention trialsClinical trialsUrinary metabolitesCreatinineDay 0Whey supplementationWhey supplementsIntakeSample t-testSimilar increaseTrialsT-testSupplementationMarkers
2011
Using urinary nitrogen and urea to predict dietary protein intake: a controlled clinical trial
Bihuniak J, Simpson C, Sullivan R, Kerstetter J, Insogna K. Using urinary nitrogen and urea to predict dietary protein intake: a controlled clinical trial. The FASEB Journal 2011, 25: 600.3-600.3. DOI: 10.1096/fasebj.25.1_supplement.600.3.Peer-Reviewed Original ResearchProtein intakeSupplementation trialWhey supplementationUrinary ureaBone turnover markersDietary protein intakeBone mineral densityPostmenopausal womenTurnover markersBone turnoverClinical trialsMineral densityUCreatDay 0Urine nitrogenWhey supplementsOutcome variablesIntakeTrialsMaltodextrin supplementUrinary nitrogenBone centersSupplementationSupplementsCostly alternative
2010
Optimizing bone health in older adults: the importance of dietary protein
Surdykowski AK, Kenny AM, Insogna KL, Kerstetter JE. Optimizing bone health in older adults: the importance of dietary protein. Aging Health 2010, 6: 345-357. PMID: 20657805, PMCID: PMC2907525, DOI: 10.2217/ahe.10.16.BooksBone healthBone lossDietary proteinAge-related bone lossDietary protein recommendationsSkeletal healthVitamin DDietary calciumMuscle strengthCalcium absorptionCalcium metabolismBone balanceIGF-1Protein intakeProtein recommendationsOlder adultsHealthModerate increasePivotal roleOsteoporosisProtein contributesProteinIntakeThe Effect of Dietary Protein on Intestinal Calcium Absorption in Rats
Gaffney-Stomberg E, Sun BH, Cucchi CE, Simpson CA, Gundberg C, Kerstetter JE, Insogna KL. The Effect of Dietary Protein on Intestinal Calcium Absorption in Rats. Endocrinology 2010, 151: 1071-1078. PMID: 20147526, PMCID: PMC2840679, DOI: 10.1210/en.2009-0744.Peer-Reviewed Original ResearchConceptsIntestinal Ca absorptionCa absorptionHigh-protein dietUrinary calciumBrush border membrane vesiclesProtein intakeFemale Sprague-Dawley ratsProtein dietProtein intake resultsIntestinal calcium absorptionDietary protein intakeHigh protein intakeSprague-Dawley ratsLow-protein groupHigh protein groupDietary protein effectsCalcium absorptionAcute increaseDawley ratsDuodenal mucosaIntake resultsRatsCa balanceTranscellular CaDietary protein
2009
Increasing Dietary Protein Requirements in Elderly People for Optimal Muscle and Bone Health
Gaffney‐Stomberg E, Insogna KL, Rodriguez NR, Kerstetter JE. Increasing Dietary Protein Requirements in Elderly People for Optimal Muscle and Bone Health. Journal Of The American Geriatrics Society 2009, 57: 1073-1079. PMID: 19460090, DOI: 10.1111/j.1532-5415.2009.02285.x.BooksConceptsRecommended Dietary AllowanceCurrent Recommended Dietary AllowanceDietary proteinImportant public health goalOlder individualsInsulin-like growth factorElderly peopleNormal calcium metabolismLoss of boneMuscle protein synthesisShort-term proteinMaintenance of musclePublic health goalsRenal functionBone healthSignificant morbidityCalcium absorptionCalcium metabolismSupplement trialAnabolic effectsClinical studiesProtein adequacyAnabolic responseProtein intakeMuscle massA Rodent Model to Evaluate the Effect of Dietary Protein on Intestinal Calcium Absorption
Gaffney‐Stomberg E, Cucchi C, Sun B, Simpson C, Kerstetter J, Insogna K. A Rodent Model to Evaluate the Effect of Dietary Protein on Intestinal Calcium Absorption. The FASEB Journal 2009, 23: 726.1-726.1. DOI: 10.1096/fasebj.23.1_supplement.726.1.Peer-Reviewed Original ResearchHigh-protein dietLow-protein groupCa absorptionProtein dietBone turnoverBrush border membrane vesiclesIntestinal Ca absorptionIntestinal calcium absorptionDietary proteinVitamin D metabolitesLow protein intakeCa transportLow-protein dietSerum PTHSerum osteocalcinHr urineCalcium absorptionD metabolitesSerum CaDuodenal mucosaUrine CaRodent modelsAnimal modelsProtein intakeCa metabolism
2003
Dietary protein, calcium metabolism, and skeletal homeostasis revisited
Kerstetter JE, O'Brien KO, Insogna KL. Dietary protein, calcium metabolism, and skeletal homeostasis revisited. American Journal Of Clinical Nutrition 2003, 78: s584-s592. PMID: 12936953, DOI: 10.1093/ajcn/78.3.584s.BooksConceptsIntestinal calcium absorptionDietary protein intakeCalcium absorptionProtein intakeDietary proteinBone resorptionHigher dietary protein intakeSerum parathyroid hormoneUrinary calcium excretionCalcium balance studiesReduced bone densityRecent epidemiologic studiesLow protein intakeDiet-induced changesLow-protein dietCalcium excretionSecondary hyperparathyroidismCalcium intakeUrinary calciumParathyroid hormoneBone lossSkeletal healthCalcium metabolismDietary trialMineral metabolism
2000
A threshold for low-protein-diet–induced elevations in parathyroid hormone 1 , 2 , 3
Kerstetter J, Svastisalee C, Caseria D, Mitnick M, Insogna K. A threshold for low-protein-diet–induced elevations in parathyroid hormone 1 , 2 , 3. American Journal Of Clinical Nutrition 2000, 72: 168-173. PMID: 10871576, DOI: 10.1093/ajcn/72.1.168.Peer-Reviewed Original ResearchConceptsYoung healthy womenParathyroid hormoneHealthy womenCalcium homeostasisDay 4Nephrogenous cyclic adenosine monophosphateDiet-induced elevationIntestinal calcium absorptionBody mass indexDietary proteinDietary protein intakeParathyroid hormone 1Protein/Urinary calciumCalcitropic hormonesMass indexCalcium absorptionPerturb calcium homeostasisMean 24Normal rangeAverage ageProtein intakeDietary allowanceCyclic adenosine monophosphateHormone 1
1999
Changes in Bone Turnover in Young Women Consuming Different Levels of Dietary Protein1
Kerstetter J, Mitnick M, Gundberg C, Caseria D, Ellison A, Carpenter T, Insogna K. Changes in Bone Turnover in Young Women Consuming Different Levels of Dietary Protein1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 1052-1055. PMID: 10084594, DOI: 10.1210/jcem.84.3.5552.Peer-Reviewed Original ResearchUrinary N-telopeptide excretionBone-specific alkaline phosphataseN-telopeptide excretionUrinary calcium excretionBone turnoverLow-protein dietCalcium excretionUrinary calciumProtein dietBone resorptionDietary proteinYoung womenHealthy young womenNegative calcium balanceLow protein intakeHigh-protein dietAlkaline phosphataseSecondary hyperparathyroidismSerum PTHSerum osteocalcinDihydroxyvitamin DCalcium balanceProtein intakeCompensatory increaseDay 4