2024
Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon
Castillo S, Alvarez C, Rosas-Aguirre Á, Acosta C, Corder R, Gómez J, Guzmán M, Speybroeck N, Llanos-Cuentas A, Castro M, Rosanas-Urgell A, Ferreira M, Vinetz J, Gamboa D, Torres K. Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon. PLOS Neglected Tropical Diseases 2024, 18: e0012566. PMID: 39480785, PMCID: PMC11527163, DOI: 10.1371/journal.pntd.0012566.Peer-Reviewed Original ResearchConceptsRisk of P. vivax infectionPlasmodium vivax malaria transmissionFactors associated with recurrenceVivax malaria transmissionPlasmodium vivax infectionMalaria-endemic areasPopulation-based cohort studyFrequency of recurrenceApplication of molecular diagnostic methodsMalaria recurrenceMalaria infectionMalaria transmissionVivax infectionRecurrence rateMolecular diagnostic methodsRecurrence riskConsequences of prolonged exposureFollow-upCohort studyEndemic settingsRecurrenceAsymptomatic infectionAsymptomatic casesInfectionInitial infection
2021
Clinical spectrum of endemic leptospirosis in relation to cytokine response
Dahanayaka NJ, Agampodi SB, Seneviratna I, Warnasekara J, Rajapakse R, Ranathunga K, Matthias M, Vinetz JM. Clinical spectrum of endemic leptospirosis in relation to cytokine response. PLOS ONE 2021, 16: e0261025. PMID: 34879100, PMCID: PMC8654203, DOI: 10.1371/journal.pone.0261025.Peer-Reviewed Original ResearchConceptsCytokine responsesLeptospirosis patientsClinical spectrumHigher IL-13 levelsHigher IL-5Acute kidney injuryHigher serum creatinineIL-13 levelsSerum cytokine levelsIL-6 levelsUniversity Teaching HospitalMultiplex cytokine kitKidney injuryLung involvementCytokine levelsSerum creatinineAcute phaseCytokine kitIL-1βAcute samplesConvalescence periodIL-8IL-5Prognostic informationEndemic settingsOptimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity
Jayasundara D, Gamage C, Senavirathna I, Warnasekara J, Matthias MA, Vinetz J, Agampodi S. Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity. PLOS Neglected Tropical Diseases 2021, 15: e0009565. PMID: 34197457, PMCID: PMC8279374, DOI: 10.1371/journal.pntd.0009565.Peer-Reviewed Original ResearchNext-Generation Sequencing Analysis of Pathogenic Leptospira: A Way Forward for Understanding Infectious Disease Dynamics in Low/Middle-Income, Disease-Endemic Settings.
Agampodi SB, Vinetz JM. Next-Generation Sequencing Analysis of Pathogenic Leptospira: A Way Forward for Understanding Infectious Disease Dynamics in Low/Middle-Income, Disease-Endemic Settings. American Journal Of Tropical Medicine And Hygiene 2021, 104: 1625-1627. PMID: 33755589, PMCID: PMC8103479, DOI: 10.4269/ajtmh.20-1518.Peer-Reviewed Original Research
2016
Epidemiology of Plasmodium vivax Malaria in Peru
Rosas-Aguirre A, Gamboa D, Manrique P, Conn JE, Moreno M, Lescano AG, Sanchez JF, Rodriguez H, Silva H, Llanos-Cuentas A, Vinetz JM. Epidemiology of Plasmodium vivax Malaria in Peru. American Journal Of Tropical Medicine And Hygiene 2016, 95: 133-144. PMID: 27799639, PMCID: PMC5201219, DOI: 10.4269/ajtmh.16-0268.Peer-Reviewed Original ResearchConceptsMalaria transmissionP. vivaxMalaria controlPlasmodium falciparum malaria casesMicroscopy-confirmed casesP. vivax malaria transmissionFalciparum malaria casesPlasmodium vivax malariaVivax malaria transmissionPublic health problemGlucose-6-phosphate dehydrogenase deficiencyFuture malaria controlImplementation of surveillanceCombination therapyVivax malariaClinical trialsMalaria casesPlasmodium vivaxElimination effortsHealth problemsP. falciparumMosquito transmissionDehydrogenase deficiencyVivaxOngoing surveillance activities
2005
Clinical Spectrum of Pulmonary Involvement in Leptospirosis in a Region of Endemicity, with Quantification of Leptospiral Burden
Segura ER, Ganoza CA, Campos K, Ricaldi JN, Torres S, Silva H, Céspedes MJ, Matthias MA, Swancutt MA, Liñán R, Gotuzzo E, Guerra H, Gilman RH, Vinetz JM, Consortium P. Clinical Spectrum of Pulmonary Involvement in Leptospirosis in a Region of Endemicity, with Quantification of Leptospiral Burden. Clinical Infectious Diseases 2005, 40: 343-351. PMID: 15668855, PMCID: PMC2366057, DOI: 10.1086/427110.Peer-Reviewed Original ResearchConceptsPulmonary involvementFebrile patientsAcute respiratory distress syndromeMost fatal casesSevere pulmonary manifestationsRespiratory distress syndromePopulation-based studyEvidence of exposureDiagnosis of leptospirosisRegions of endemicityPulmonary complicationsMultiorgan failurePulmonary manifestationsPresumptive treatmentDistress syndromePulmonary hemorrhageSerologic testingIgM antibodiesClinical spectrumPulmonary casesFatal casesQuantitative real-time PCRReal-time PCRAntileptospiral antibodiesLeptospiral burden