2020
Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study
Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/s2352-3026(20)30216-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBetacoronavirusBiomarkersBlood Coagulation DisordersCoronavirus InfectionsCOVID-19Critical IllnessCross-Sectional StudiesEndothelium, VascularFemaleFollow-Up StudiesHumansIntensive Care UnitsMaleMiddle AgedPandemicsPneumonia, ViralPrognosisSARS-CoV-2Vascular DiseasesYoung AdultConceptsCOVID-19-associated coagulopathyNon-ICU patientsIntensive care unitKaplan-Meier analysisSoluble P-selectinCross-sectional studyPlatelet activationHospital dischargeICU patientsSoluble thrombomodulinEndothelial cellsVWF antigenCOVID-19P-selectinSingle-center cross-sectional studyLaboratory-confirmed COVID-19Medical intensive care unitSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesisVon Willebrand factor antigenSoluble thrombomodulin concentrationsVWF antigen concentrationEndothelial cell injurySoluble CD40 ligandMicrovascular complicationsAdult patients
2015
Protocols and Hospital Mortality in Critically Ill Patients
Sevransky JE, Checkley W, Herrera P, Pickering BW, Barr J, Brown SM, Chang SY, Chong D, Kaufman D, Fremont RD, Girard TD, Hoag J, Johnson SB, Kerlin MP, Liebler J, O’Brien J, O’Keefe T, Park PK, Pastores SM, Patil N, Pietropaoli AP, Putman M, Rice TW, Rotello L, Siner J, Sajid S, Murphy DJ, Martin GS. Protocols and Hospital Mortality in Critically Ill Patients. Critical Care Medicine 2015, 43: 2076-2084. PMID: 26110488, PMCID: PMC5673100, DOI: 10.1097/ccm.0000000000001157.Peer-Reviewed Original ResearchConceptsHospital mortalityIll patientsProtocol complianceClinical protocolsUnited States Critical IllnessAcute respiratory distress syndromeSpontaneous breathing trialLung-protective ventilationRespiratory distress syndromeLength of stayComplete outcome dataPatients 1 dayVentilator management protocolsSuperior patient outcomesLack of associationSingle variable analysisDesirable therapyBreathing trialProtective ventilationCritical illnessDistress syndromeICU protocolPrimary outcomeMechanical ventilationMultivariable analysis
2014
Structure, Process, and Annual ICU Mortality Across 69 Centers
Checkley W, Martin GS, Brown SM, Chang SY, Dabbagh O, Fremont RD, Girard TD, Rice TW, Howell MD, Johnson SB, O’Brien J, Park PK, Pastores SM, Patil NT, Pietropaoli AP, Putman M, Rotello L, Siner J, Sajid S, Murphy DJ, Sevransky JE. Structure, Process, and Annual ICU Mortality Across 69 Centers. Critical Care Medicine 2014, 42: 344-356. PMID: 24145833, PMCID: PMC4035482, DOI: 10.1097/ccm.0b013e3182a275d7.Peer-Reviewed Original ResearchConceptsChronic Health Evaluation IIICU mortalityProcess of careAcute PhysiologyUse of protocolsClinical outcomesNurse ratioEvaluation IICare reviewChronic Health Evaluation II scoreUnited States Critical IllnessAverage Acute PhysiologyHospital-level variationMultivariable linear regressionHouse intensivistICU statusIntensivist staffingMixed ICUII scoreCritical illnessMedical ICUSurgical ICUICU patientsIllness severityIntensivist coverage