2024
Coordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging
Jeng G, Chen P, Hsieh M, Liu Z, Langdon J, Ahn S, Staib L, Stendahl J, Thorn S, Sinusas A, Duncan J, O'Donnell M. Coordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging. IEEE Transactions On Biomedical Engineering 2024, 71: 3312-3323. PMID: 38941195, DOI: 10.1109/tbme.2024.3420220.Peer-Reviewed Original ResearchPrincipal stretchesAxial displacement componentsSpeckle tracking methodSpeckle tracking approachTracking methodRobust filterDisplacement componentsTissue incompressibilityDisplacement estimationStrain componentsDisplacement gradientsStrain informationLocalized diseased regionStrain imagingLagrangian strainLeast-squares methodTracking approachTracking frameworkCoordinate systemCardiac coordinate systemProbe orientationFilterHigher spatial resolutionCardiac datasetsEnhanced accuracyThe Clinical Trajectory of NYHA Functional Class I Patients With Obstructive Hypertrophic Cardiomyopathy
Ahluwalia M, Liu J, Olivotto I, Parikh V, Ashley E, Michels M, Ingles J, Lampert R, Stendahl J, Colan S, Abrams D, Pereira A, Rossano J, Ryan T, Owens A, Ware J, Saberi S, Helms A, Day S, Claggett B, Ho C, Lakdawala N. The Clinical Trajectory of NYHA Functional Class I Patients With Obstructive Hypertrophic Cardiomyopathy. JACC Heart Failure 2024 PMID: 39520446, DOI: 10.1016/j.jchf.2024.09.008.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathyClass I patientsFunctional class II patientsNYHA functional class IClass II patientsFunctional class II patientsII patientsHypertrophic cardiomyopathyFollow-upLeft ventricular outflow tract obstructionVentricular outflow tract obstructionNYHA functional class IILeft ventricular ejection fractionRates of clinical outcomesClass INatural historyRestricted cubic spline modelsSeptal reduction therapyOutflow tract obstructionFunctional class IIVentricular ejection fractionComposite event rateCubic spline modelsCox proportional hazardsLong-Term Outcomes After Septal Reduction Therapies in Obstructive Hypertrophic Cardiomyopathy: Insights From the SHARE Registry
Maurizi N, Antiochos P, Owens A, Lakdwala N, Saberi S, Russell M, Fumagalli C, Skalidis I, Lin K, Nathan A, De Feria Alsina A, Reza N, Stendahl J, Abrams D, Semsarian C, Clagget B, Lampert R, Wheeler M, Parikh V, Ashley E, Michels M, Rossano J, Ryan T, Ingles J, Ware J, Ho C, Helms A, Day S, Olivotto I. Long-Term Outcomes After Septal Reduction Therapies in Obstructive Hypertrophic Cardiomyopathy: Insights From the SHARE Registry. Circulation 2024, 150: 1377-1390. PMID: 39355918, PMCID: PMC11493522, DOI: 10.1161/circulationaha.124.069378.Peer-Reviewed Original ResearchSeptal reduction therapyHCM-related deathOutflow tract obstructionObstructive hypertrophic cardiomyopathyHypertrophic cardiomyopathyHeart failureComposite outcomeMaximal left ventricular outflow tract gradientRecurrent left ventricular outflow tract obstructionRelief of outflow tract obstructionLeft ventricular outflow tract gradientLeft ventricular outflow tract obstructionReduction therapyVentricular outflow tract obstructionDe novo atrial fibrillationPredictor of adverse outcomesOccurrence of heart failureAlcohol septal ablationOutflow tract gradientEvent-free survivalLong-term disease courseHypertrophic cardiomyopathy centersLong-term reliefCox proportional hazards modelsLong-term outcomesAdaptive Correspondence Scoring for Unsupervised Medical Image Registration
Zhang X, Stendahl J, Staib L, Sinusas A, Wong A, Duncan J. Adaptive Correspondence Scoring for Unsupervised Medical Image Registration. Lecture Notes In Computer Science 2024, 15096: 76-92. DOI: 10.1007/978-3-031-72920-1_5.Peer-Reviewed Original ResearchMedical image registrationAdaptation frameworkMedical image datasetsUnsupervised learning schemeAdaptive training schemeImage registrationError residualsSupervision signalsLearning schemeImage datasetsRegistration architectureIntensity constancyScore mapNoisy gradientsMedical imagesTraining schemeImage reconstructionPerformance degradationLambertian assumptionCorrespondence scoresLoss of correspondenceTraining objectivesDisplacement estimationImage acquisitionSchemeContrast‐enhanced computed tomography for ex vivo assessment of human kidneys: A proof‐of‐concept study
Feizi A, DiRito J, Richfield O, Stendahl J, Harris M, Spindler S, Edwards C, Lysyy T, Lee S, Boutagy N, Feher A, Yoo P, Hosgood S, Mulligan D, Nicholson M, Sinusas A, Haakinson D, Tietjen G. Contrast‐enhanced computed tomography for ex vivo assessment of human kidneys: A proof‐of‐concept study. Artificial Organs 2024, 48: 1536-1548. PMID: 39189738, DOI: 10.1111/aor.14840.Peer-Reviewed Original ResearchContrast-enhanced computed tomographyNormothermic perfusionComputed tomographyHuman kidneyLocal informationAnalysis of biopsiesAssess organ functionNovel therapeutic strategiesEx vivo assessmentWhole organ perfusionProof-of-concept studyEx vivo perfusionInfusion scansAnatomical structuresOrgan perfusionPrototype catheter-based device for real time dual-isotope myocardial mapping
Stendahl J, Vermillion B, Daghighian F, Sinusas A. Prototype catheter-based device for real time dual-isotope myocardial mapping. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.049. DOI: 10.1093/ehjci/jeae142.049.Peer-Reviewed Original ResearchMulti-Task Learning for Motion Analysis and Segmentation in 3D Echocardiography
Ta K, Ahn S, Thorn S, Stendahl J, Zhang X, Langdon J, Staib L, Sinusas A, Duncan J. Multi-Task Learning for Motion Analysis and Segmentation in 3D Echocardiography. IEEE Transactions On Medical Imaging 2024, 43: 2010-2020. PMID: 38231820, PMCID: PMC11514714, DOI: 10.1109/tmi.2024.3355383.Peer-Reviewed Original ResearchMulti-task learning networkCross-stitch unitsComposite loss functionAccurate motion estimationTask-specific networksMotion estimationSegmentation masksLearning networkLoss functionSegmentation stepEchocardiography datasetNetworkMotion displacementMotion analysisMultiple time framesTaskAnalysis pipelineSegmentsStrain measurementsDatasetRepresentationLong‐Term Safety and Efficacy of Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results of the PIONEER‐OLE Study
Masri A, Lester S, Stendahl J, Hegde S, Sehnert A, Balaratnam G, Shah A, Fox S, Wang A. Long‐Term Safety and Efficacy of Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results of the PIONEER‐OLE Study. Journal Of The American Heart Association 2024, 13: e030607. PMID: 38591260, PMCID: PMC11262496, DOI: 10.1161/jaha.123.030607.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathyKansas City Cardiomyopathy Questionnaire–Overall Summary scoreSymptomatic obstructive hypertrophic cardiomyopathyOutflow tract gradientHypertrophic cardiomyopathyNew York Heart Association class improvementLeft ventricular outflow tract gradientTreatment-emergent adverse eventsSerum NT-proBNP levelsLeft ventricular ejection fractionEffect of mavacamtenIndividual dose titrationNT-proBNP levelsVentricular ejection fractionSerum NT-proBNPSummary scoreLong-term safetyLonger-term treatmentDose titrationEjection fractionNT-proBNPB-blockersReduced doseAdverse eventsInterim resultsPREDICTORS OF ADVERSE LONG-TERM OUTCOME AFTER SEPTAL REDUCTION THERAPIES IN OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY : INSIGHTS FROM THE SHARE REGISTRY
Maurizi N, Antiochos P, Owens A, Lakdawala N, Saberi S, Russell M, Lin K, De Feria Alsina A, Reza N, Stendahl J, Abrams D, Semsarian C, Lampert R, Parikh V, Wheeler M, Ashley E, Michels M, Rossano J, Ryan T, Ingles J, Ware J, Ho C, Helms A, Day S, Olivotto I. PREDICTORS OF ADVERSE LONG-TERM OUTCOME AFTER SEPTAL REDUCTION THERAPIES IN OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY : INSIGHTS FROM THE SHARE REGISTRY. Journal Of The American College Of Cardiology 2024, 83: 353. DOI: 10.1016/s0735-1097(24)02343-x.Peer-Reviewed Original ResearchContractile phenotypes of engineered heart tissues derived from hypertrophic cardiomyopathy patients lacking sarcomeric mutations
Rasheed Y, Young S, Halder S, Li X, Stendahl J, Campbell S. Contractile phenotypes of engineered heart tissues derived from hypertrophic cardiomyopathy patients lacking sarcomeric mutations. Biophysical Journal 2024, 123: 388a. DOI: 10.1016/j.bpj.2023.11.2357.Peer-Reviewed Original Research
2023
Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress
Stendahl J, Liu Z, Boutagy N, Parajuli N, Lu A, Alkhalil I, Lin B, Duncan J, Sinusas A. Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress. AJP Heart And Circulatory Physiology 2023, 325: h492-h509. PMID: 37417870, PMCID: PMC10538990, DOI: 10.1152/ajpheart.00735.2022.Peer-Reviewed Original ResearchConceptsLow-dose dobutaminePressure-strain loopsCoronary stenosisMyocardial workRegional myocardial workPressure-strain analysisDobutamine stressBlood flowLow-dose dobutamine stressInvasive hemodynamic monitoringMid-left anteriorLow cardiac outputRegional myocardial blood flowCoronary blood flowIschemic heart diseasePresence of ischemiaMyocardial work indexModerate coronary stenosisMyocardial blood flowOpen-chest modelEjection of bloodInotropic supportPressure-strain relationshipHemodynamic monitoringCardiac outputLeft Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry
Alaiwi S, Roston T, Marstrand P, Claggett B, Parikh V, Helms A, Ingles J, Lampert R, Lakdawala N, Michels M, Owens A, Rossano J, Saberi S, Abrams D, Ashley E, Semsarian C, Stendahl J, Ware J, Miller E, Ryan T, Russell M, Day S, Olivotto I, Vissing C, Ho C. Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry. Circulation 2023, 148: 394-404. PMID: 37226762, PMCID: PMC10373850, DOI: 10.1161/circulationaha.122.062517.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic dysfunctionHypertrophic cardiomyopathyMedian ageHCM diagnosisVentricular assist device implantationCox proportional hazards modelComposite of deathVentricular systolic dysfunctionAssist device implantationVentricular ejection fractionProportional hazards modelCardiac transplantationSystolic dysfunctionEjection fractionHCM cohortPediatric cohortDevice implantationPoor outcomeSubsequent prognosisEchocardiographic reportsHazards modelPatientsAdult cohortPrognosisCohortSegmentation-Free PVC for Cardiac SPECT Using a Densely-Connected Multi-Dimensional Dynamic Network
Xie H, Liu Z, Shi L, Greco K, Chen X, Zhou B, Feher A, Stendahl J, Boutagy N, Kyriakides T, Wang G, Sinusas A, Liu C. Segmentation-Free PVC for Cardiac SPECT Using a Densely-Connected Multi-Dimensional Dynamic Network. IEEE Transactions On Medical Imaging 2023, 42: 1325-1336. PMID: 36459599, PMCID: PMC10204821, DOI: 10.1109/tmi.2022.3226604.Peer-Reviewed Original ResearchRadiotracers to address unmet clinical needs in cardiovascular imaging, part 2: inflammation, fibrosis, thrombosis, calcification, and amyloidosis imaging
Stendahl J, Kwan J, Pucar D, Sadeghi M. Radiotracers to address unmet clinical needs in cardiovascular imaging, part 2: inflammation, fibrosis, thrombosis, calcification, and amyloidosis imaging. Chinese Journal Of Nuclear Medicine And Molecular Imaging 2023, 43: 187-192. DOI: 10.3760/cma.j.cn321828-20221103-00333.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLONG-TERM SAFETY AND EFFICACY OF MAVACAMTEN IN PATIENTS (PTS) WITH SYMPTOMATIC OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (HCM): UPDATED RESULTS FROM THE PIONEER-OLE STUDY
Masri A, Lester S, Stendahl J, Hegde S, Sehnert A, Balaratnam G, Fox S, Wang A. LONG-TERM SAFETY AND EFFICACY OF MAVACAMTEN IN PATIENTS (PTS) WITH SYMPTOMATIC OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (HCM): UPDATED RESULTS FROM THE PIONEER-OLE STUDY. Journal Of The American College Of Cardiology 2023, 81: 346. DOI: 10.1016/s0735-1097(23)00790-8.Peer-Reviewed Original ResearchRadiotracers to address unmet clinical needs in cardiovascular imaging, part 1: technical considerations and perfusion and neuronal imaging
Stendahl J, Kwan J, Pucar D, Sadeghi M. Radiotracers to address unmet clinical needs in cardiovascular imaging, part 1: technical considerations and perfusion and neuronal imaging. Chinese Journal Of Nuclear Medicine And Molecular Imaging 2023, 43: 122-128. DOI: 10.3760/cma.j.cn321828-20221009-00301.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging
Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging. Journal Of Nuclear Medicine 2022, 63: 986-994. PMID: 35772956, PMCID: PMC9258561, DOI: 10.2967/jnumed.121.263507.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiovascular imagingDevice-related thrombusDetection of thrombusUnmet diagnostic needsFibroblast activation proteinCardiovascular fibrosisCardiovascular inflammationRisk stratificationDiagnostic needsCardiovascular calcificationMyocardial infarctionInflammatory responseUnmet ClinicalNew radiotracersCardiovascular medicinePersonalized therapyFibrosisActivation proteinSPECT imagingAmyloidosisCalcificationThrombosisInflammationRadiotracer developmentThrombusRadiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging.
Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging. Journal Of Nuclear Medicine 2022, 63: 649-658. PMID: 35487563, DOI: 10.2967/jnumed.121.263506.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnmet diagnostic needsCardiovascular medicineNeuronal imagingImaging of inflammationHeart failureValvular diseaseTechnical considerationsDiagnostic needsCardiac amyloidosisUnmet ClinicalNew radiotracersCardiovascular imagingPersonalized therapyPerfusion tracerPET perfusion tracerThrombosisRadiotracer developmentRadiotracerPerfusionF-FlurpiridazImagingReviewMedicineKey technical considerationsMolecular characterizationSimultaneous Segmentation and Motion Estimation of Left Ventricular Myocardium in 3D Echocardiography Using Multi-task Learning
Ta K, Ahn SS, Stendahl JC, Langdon J, Sinusas AJ, Duncan JS. Simultaneous Segmentation and Motion Estimation of Left Ventricular Myocardium in 3D Echocardiography Using Multi-task Learning. Lecture Notes In Computer Science 2022, 13131: 123-131. PMID: 35759335, PMCID: PMC9221412, DOI: 10.1007/978-3-030-93722-5_14.Peer-Reviewed Original ResearchMotion estimationMulti-task learning networkMedical image analysis literatureMulti-task learningSingle-task learningMotion estimation techniqueImage analysis literatureComputer visionDecoding branchesFeature encoderLearning frameworkLearning networkLatent featuresAccurate segmentationSimultaneous segmentationEstimate motionImage pairsTask learningRealistic motion patternsVolumetric segmentationSegmentationMotion patternsTaskUnique taskLearning
2021
Learning-Based Regularization for Cardiac Strain Analysis via Domain Adaptation
Lu A, Ahn SS, Ta K, Parajuli N, Stendahl JC, Liu Z, Boutagy NE, Jeng GS, Staib LH, O’Donnell M, Sinusas AJ, Duncan JS. Learning-Based Regularization for Cardiac Strain Analysis via Domain Adaptation. IEEE Transactions On Medical Imaging 2021, 40: 2233-2245. PMID: 33872145, PMCID: PMC8442959, DOI: 10.1109/tmi.2021.3074033.Peer-Reviewed Original Research