2022
Adherence to Guidelines in Heart Failure, Is It Valid for Elderly Patients?
Khoury J, Ghersin I, Braun E, Elias A, Aronson D, Azzam Z, Bahouth F. Adherence to Guidelines in Heart Failure, Is It Valid for Elderly Patients? Israel Medical Association Journal 2022, 24: 757-762. PMID: 36436045.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureAngiotensin receptor blockersPatients 80 yearsEjection fractionHeart failureMedicine groupSingle-center retrospective studyDecompensated heart failureReduced ejection fractionLarge prospective studiesRandomized clinical trialsOlder adult populationGDMT groupMineralocorticoid antagonistsCause mortalityReceptor blockersValue of guidelinesElderly patientsHospital dischargeOlder patientsYounger patientsMedical therapyPrimary outcomeProspective studyRetrospective study
2019
Blood urea nitrogen variation upon admission and at discharge in patients with heart failure
Khoury J, Bahouth F, Stabholz Y, Elias A, Mashiach T, Aronson D, Azzam Z. Blood urea nitrogen variation upon admission and at discharge in patients with heart failure. ESC Heart Failure 2019, 6: 809-816. PMID: 31199082, PMCID: PMC6676277, DOI: 10.1002/ehf2.12471.Peer-Reviewed Original ResearchConceptsBlood urea nitrogenDay mortality rateHeart failureHigher BUN levelsPrognostic predictorBUN levelsMortality rateAcute decompensated heart failureDecompensated heart failureLong-term mortalityBrain natriuretic peptideGlomerular filtration rateShort-term mortalityLack of improvementBUN changeDay mortalityHospital stayCreatinine levelsFirst hospitalizationFirst admissionWorse prognosisMean ageNatriuretic peptidePrognostic valueRetrospective study
2018
The association between treatment appropriateness according to EUCAST and CLSI breakpoints and mortality among patients with candidemia: a retrospective observational study
Ghanem-Zoubi N, Zorbavel D, Khoury J, Geffen Y, Qasum M, Predescu S, Paul M. The association between treatment appropriateness according to EUCAST and CLSI breakpoints and mortality among patients with candidemia: a retrospective observational study. European Journal Of Clinical Microbiology & Infectious Diseases 2018, 37: 2397-2404. PMID: 30284179, DOI: 10.1007/s10096-018-3389-1.Peer-Reviewed Original ResearchConceptsCLSI 2012Appropriate antifungal treatmentDefinitive treatmentOdds ratioAntifungal treatmentAntimicrobial Susceptibility Testing (EUCAST) breakpointsAppropriate definitive treatmentRetrospective observational studyAdjusted odds ratioAppropriate empirical treatmentBivariate logistic regressionCandidemia onsetCandidemia episodesEmpiric treatmentTreatment appropriatenessTertiary centerRetrospective studyCLSI breakpointsEmpirical treatmentObservational studyBreakpoint definitionPatientsResistance prevalenceMortalityLogistic regression