BRAF V600E mutation in papillary thyroid microcarcinoma: a genotype–phenotype correlation
Virk RK, Van Dyke AL, Finkelstein A, Prasad A, Gibson J, Hui P, Theoharis CG, Carling T, Roman SA, Sosa JA, Udelsman R, Prasad ML. BRAF V600E mutation in papillary thyroid microcarcinoma: a genotype–phenotype correlation. Modern Pathology 2012, 26: 62-70. PMID: 22918165, DOI: 10.1038/modpathol.2012.152.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, PapillaryDNA Mutational AnalysisFemaleGenetic Association StudiesGenotypeHumansMaleMiddle AgedMutationPhenotypePolymorphism, Single-Stranded ConformationalProto-Oncogene Proteins B-rafThyroid NeoplasmsYoung AdultConceptsPapillary thyroid microcarcinomaThyroid microcarcinomaPapillary thyroid carcinomaFollicular variantThyroid carcinomaLateral cervical node metastasesOsteoclastic-type giant cellsCervical node metastasisInfiltrative tumor borderGroup of tumorsBRAF V600E mutationClassic nuclear featuresGenotype-phenotype correlationStromal calcificationLymphovascular invasionNode metastasisClinicopathologic featuresLymphocytic infiltrationAggressive featuresTumor sizeCystic changesPapillary microcarcinomaAbsence of mutationsHigh prevalenceMicrocarcinoma