2024
Distinct epigenetic and transcriptional profiles of Epstein-Barr virus (EBV) positive and negative primary CNS lymphomas
Hai L, Friedel D, Hinz F, Hoffmann D, Doubrovinskaia S, Rohdjess H, Weidenauer K, Denisova E, Scheffler G, Kessler T, Kourtesakis A, Herold-Mende C, Henegariu O, Baehring J, Dietrich J, Brors B, Wick W, Sahm F, Kaulen L. Distinct epigenetic and transcriptional profiles of Epstein-Barr virus (EBV) positive and negative primary CNS lymphomas. Neuro-Oncology 2024, noae251. PMID: 39575767, DOI: 10.1093/neuonc/noae251.Peer-Reviewed Original ResearchPrimary CNS lymphomaEpstein-Barr virusB cell receptorCNS lymphomaTargeted therapyEpigenetic profilesB cellsDiffuse large B-cell lymphomaLarge B-cell lymphomaB-cell lymphomaPromoter region hypermethylationEBV oncogeneEBV lymphomasEBV- tumorsEPIC methylation arrayWnt/beta-catenin signalingEBV diseaseBiological subtypesUnsupervised cluster analysisInterleukin-10Promoter methylationLymphomaSyk kinase activityBrain tumorsMutational landscapePATH-35. INTEGRATED GENOMIC ANALYSES OF IMMUNODEFICIENCY-ASSOCIATED EPSTEIN-BARR VIRUS- (EBV) POSITIVE PRIMARY CNS LYMPHOMAS
Kaulen L, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, Hoffmann D, Ito J, Kourtesakis A, Lehnert P, Doubrovinskaia S, Karschnia P, von Baumgarten L, Kessler T, Baehring J, Brors B, Sahm F, Wick W. PATH-35. INTEGRATED GENOMIC ANALYSES OF IMMUNODEFICIENCY-ASSOCIATED EPSTEIN-BARR VIRUS- (EBV) POSITIVE PRIMARY CNS LYMPHOMAS. Neuro-Oncology 2024, 26: viii186-viii186. PMCID: PMC11553229, DOI: 10.1093/neuonc/noae165.0734.Peer-Reviewed Original ResearchPrimary CNS lymphomaEpstein-Barr virusRNAseq dataSingle nucleotide variantsCopy number variantsComprehensive genetic analysisRNA sequencing dataCopy number gainCNS lymphomaGermline controlTumor microenvironmentNucleotide variantsSequence dataTranscript groupsTargeting motifGenetic analysisGenetic landscapeJAK/STAT signalingCytotoxic T cell responsesRNA sequencingTolerogenic tumor microenvironmentAberrant somatic hypermutationExpression of CD70T regulatory cellsT cell responsesP20.12.B INTEGRATED GENETIC ANALYSES OF IMMUNODEFICIENCY-ASSOCIATED EPSTEIN-BARR VIRUS- (EBV) POSITIVE PRIMARY CNS LYMPHOMAS
Kaulen L, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, Hoffmann D, Ito J, Kourtesakis A, Lehnert P, Doubrovinskaia S, Karschnia P, von Baumgarten L, Kessler T, Baehring J, Brors B, Sahm F, Wick W. P20.12.B INTEGRATED GENETIC ANALYSES OF IMMUNODEFICIENCY-ASSOCIATED EPSTEIN-BARR VIRUS- (EBV) POSITIVE PRIMARY CNS LYMPHOMAS. Neuro-Oncology 2024, 26: v118-v118. PMCID: PMC11485591, DOI: 10.1093/neuonc/noae144.399.Peer-Reviewed Original ResearchPrimary CNS lymphomaEpstein-Barr virusRNAseq dataSingle nucleotide variantsCopy number variantsComprehensive genetic analysisRNA sequencing dataCNS lymphomaCopy number gainTumor microenvironmentGermline controlNucleotide variantsSequence dataTranscript groupsCytotoxic T cell responsesEpstein-Barr virus-positiveTargeting motifGenetic analysisGenetic landscapeJAK/STAT signalingTolerogenic tumor microenvironmentRNA sequencingAberrant somatic hypermutationExpression of CD70T regulatory cells
2023
NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022.
Horbinski C, Nabors L, Portnow J, Baehring J, Bhatia A, Bloch O, Brem S, Butowski N, Cannon D, Chao S, Chheda M, Fabiano A, Forsyth P, Gigilio P, Hattangadi-Gluth J, Holdhoff M, Junck L, Kaley T, Merrell R, Mrugala M, Nagpal S, Nedzi L, Nevel K, Nghiemphu P, Parney I, Patel T, Peters K, Puduvalli V, Rockhill J, Rusthoven C, Shonka N, Swinnen L, Weiss S, Wen P, Willmarth N, Bergman M, Darlow S. NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022. Journal Of The National Comprehensive Cancer Network 2023, 21: 12-20. PMID: 36634606, DOI: 10.6004/jnccn.2023.0002.Peer-Reviewed Original ResearchConceptsCentral nervous system cancerNervous system cancersNCCN guidelinesCNS cancersSystem cancersPrimary spinal cord tumorsExtensive brain metastasesNCCN Guidelines InsightsMetastatic spine tumorsPrimary CNS lymphomaSpinal cord tumorsBrain metastasesCNS lymphomaSystemic therapyCord tumorsSpine tumorsLeptomeningeal metastasesSurgical managementCNS tumorsRelevant new dataSpinal ependymomasBrain tumorsCancer panelTumorsCancer