2023
AP-1–independent NFAT signaling maintains follicular T cell function in infection and autoimmunity
Seth A, Yokokura Y, Choi J, Shyer J, Vidyarthi A, Craft J. AP-1–independent NFAT signaling maintains follicular T cell function in infection and autoimmunity. Journal Of Experimental Medicine 2023, 220: e20211110. PMID: 36820828, PMCID: PMC9998660, DOI: 10.1084/jem.20211110.Peer-Reviewed Original ResearchConceptsTfh cellsT cellsFollicular helper T cellsLupus-prone miceT cell subsetsTfh cell developmentHelper T cellsHumoral immune responseT cell functionGerminal center B cellsT cell statesRenal injuryAutoantibody productionCell subsetsPrimary T cellsImmune responseB cellsPharmacologic inhibitionTherapeutic insightsCell functionGenetic disruptionNFATCell developmentCellsGene expression
2015
Circulating Follicular Helper–Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity
Choi J, Ho J, Pasoto SG, Bunin V, Kim ST, Carrasco S, Borba EF, Gonçalves CR, Costa PR, Kallas EG, Bonfa E, Craft J. Circulating Follicular Helper–Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity. Arthritis & Rheumatology 2015, 67: 988-999. PMID: 25581113, PMCID: PMC4450082, DOI: 10.1002/art.39020.Peer-Reviewed Original ResearchConceptsTfh-like cellsSLE Disease Activity IndexSystemic lupus erythematosusInducible T-cell costimulatorPD-1 expressionDisease activityT cellsBehçet's diseaseSLE patientsLupus erythematosusBlood samplesT cell-B cell collaborationCentral memory T cellsExpression of CXCR5Disease activity indexGerminal center activityMemory T cellsDeath 1 proteinFollicular helper TT-cell costimulatorActive diseaseAntibody positivityDisease durationFollicular helperIL-21
2014
Aberrant expansion of CXCR5+ memory CD4 T cells in patients with systemic lupus erythematosus
Choi J, Kim S, Kang I, Craft J. Aberrant expansion of CXCR5+ memory CD4 T cells in patients with systemic lupus erythematosus. Arthritis Research & Therapy 2014, 16: a20. PMCID: PMC4179526, DOI: 10.1186/ar4636.Peer-Reviewed Original Research
2012
Follicular helper T Cells and the B cells they help
Poholek A, Choi J, Hernandez S, Weinstein J, Kim S, Bunin V, Odegard J, DiPlacido L, Craft J. Follicular helper T Cells and the B cells they help. Arthritis Research & Therapy 2012, 14: a2. PMCID: PMC3467479, DOI: 10.1186/ar3936.Peer-Reviewed Original Research
2011
The characterization of thymus-derived natural Th17 cells and their response to inflammation. (108.9)
Nowyhed H, Bertino S, Tao J, Marks B, Choi J, Craft J. The characterization of thymus-derived natural Th17 cells and their response to inflammation. (108.9). The Journal Of Immunology 2011, 186: 108.9-108.9. DOI: 10.4049/jimmunol.186.supp.108.9.Peer-Reviewed Original ResearchNatural Th17 cellsNTh17 cellsTh17 cellsNatural T Regulatory CellsCD4 T helper cellsIL-22 secretionT regulatory (Treg) cellsCertain autoimmune conditionsFunction of Th1T helper cellsIL-17AAutoimmune conditionsRegulatory cellsIL-22Neutrophil recruitmentHelper cellsIL-1βSelf antigensIL-1R1Th1 cellsNTreg cellsIL-17RCTh2 cellsTissue destructionEffector lineages
2010
Thymic self-reactivity selects for natural Th17 cells which can be distinguished by unique markers (143.49)
Nowyhed H, Marks B, Choi J, Craft J. Thymic self-reactivity selects for natural Th17 cells which can be distinguished by unique markers (143.49). The Journal Of Immunology 2010, 184: 143.49-143.49. DOI: 10.4049/jimmunol.184.supp.143.49.Peer-Reviewed Original ResearchNatural Th17 cellsNTh17 cellsTh17 cellsIL-17RCIL-17RENatural T Regulatory CellsCD4 T helper cellsT regulatory (Treg) cellsIL-22 secretionCertain autoimmune conditionsFunction of Th1T helper cellsAutoimmune conditionsIL-17ARegulatory cellsNeutrophil recruitmentIL-22Self antigensHelper cellsTh1 cellsLevel of secretionNTreg cellsTh2 cellsTissue destructionEffector lineagesCharacterization of Human Follicular Helper T (TFH) Cells
Kim S, Choi J, DiPlacido L, Lainez B, Vlamakis V, Craft J. Characterization of Human Follicular Helper T (TFH) Cells. Clinical Immunology 2010, 135: s53. DOI: 10.1016/j.clim.2010.03.161.Peer-Reviewed Original ResearchErratum: Corrigendum: Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation
Marks B, Nowyhed H, Choi J, Poholek A, Odegard J, Flavell R, Craft J. Erratum: Corrigendum: Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation. Nature Immunology 2010, 11: 97-97. DOI: 10.1038/ni0110-97b.Peer-Reviewed Original Research
2006
Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog
Choi J, Gao W, Odegard J, Shiah H, Kashgarian M, McNiff JM, Baker DC, Cheng Y, Craft J. Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog. Arthritis & Rheumatism 2006, 54: 3277-3283. PMID: 17009262, DOI: 10.1002/art.22119.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusEnd-organ diseaseInflammatory skin diseaseMRL/Skin diseasesMRL/Faslpr miceFemale MRL/NF-kappaB inhibitorFlow cytometric analysisFaslpr miceAutoantibody titersIgG levelsLupus erythematosusLymph nodesRenal diseaseVehicle treatmentKidney diseaseHepatic toxicityTotal IgMTylophorine analogsAntichromatin autoantibodiesTherapeutic effectHistopathologic analysisMurine modelSignificant abrogationCD40 ligation of rheumatoid synovial fibroblasts regulates RANKL‐medicated osteoclastogenesis: Evidence of NF‐κB–dependent, CD40‐mediated bone destruction in rheumatoid arthritis
Lee H, Jeon H, Song E, Han M, Park S, Lee S, Yun H, Kim J, Kim J, Lee Y, Kim S, Kim H, Choi J, Kang I, Kim H, Yoo W. CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL‐medicated osteoclastogenesis: Evidence of NF‐κB–dependent, CD40‐mediated bone destruction in rheumatoid arthritis. Arthritis & Rheumatism 2006, 54: 1747-1758. PMID: 16736517, DOI: 10.1002/art.21873.Peer-Reviewed Original ResearchMeSH KeywordsArthritis, RheumatoidCarrier ProteinsCD40 AntigensCells, CulturedFibroblastsHumansI-kappa B KinaseI-kappa B ProteinsMembrane GlycoproteinsMitogen-Activated Protein Kinase 1NF-kappa BNF-KappaB Inhibitor alphaOsteoclastsP38 Mitogen-Activated Protein KinasesRANK LigandReceptor Activator of Nuclear Factor-kappa BReverse Transcriptase Polymerase Chain ReactionSynovial MembraneConceptsRheumatoid arthritis synovial fibroblastsRANKL expressionCD40 ligationSynovial fibroblastsT cellsIkappaB-alphaNF-kappaBPeripheral blood mononuclear cellsTumor necrosis factor alphaTartrate-resistant acid phosphatase (TRAP) stainingERK 1/2CD40-CD40L interactionBlood mononuclear cellsRheumatoid synovial fibroblastsArthritis synovial fibroblastsNecrosis factor alphaP38 MAPKReverse transcription-polymerase chain reactionResorption pit formationNF-kappaB inhibitorTranscription-polymerase chain reactionFormation of osteoclastsNF-kappaB activationAcid phosphatase stainingL cells
2004
Age-associated changes in the frequency of naïve, memory and effector CD8+ T cells
Hong MS, Dan JM, Choi JY, Kang I. Age-associated changes in the frequency of naïve, memory and effector CD8+ T cells. Mechanisms Of Ageing And Development 2004, 125: 615-618. PMID: 15491679, DOI: 10.1016/j.mad.2004.07.001.Peer-Reviewed Original ResearchConceptsAge-associated changesT cell subsetsEffector CD8T cellsCell subsetsFrequencies of naïveFrequency of CD8Expression of CD45RAT cell functionEffector memoryPeripheral bloodCD8CM cellsDecreased frequencyCentral memoryFlow cytometryElderly peopleCell functionSimilar frequencyNaïveCellsCCR7CD45RABloodSubsetAge-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine
Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, Craft J. Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine. The Journal Of Immunology 2004, 173: 673-681. PMID: 15210831, DOI: 10.4049/jimmunol.173.1.673.Peer-Reviewed Original ResearchConceptsT cell responsesIL-7 levelsMemory CD4Long-term CD4T cellsCell responsesInfluenza vaccineIFN-gammaInfluenza virus-specific CD4Serum IL-7 levelsEM cellsLevels of CD4Virus-specific CD4Central memory CD4Effector memory CD4Cellular immune responsesFrequency of influenzaImportant clinical questionsAge-Associated ChangesEM CD4Influenza vaccinationTNF-alphaVaccination strategiesIL-7Immune response
2003
Intrinsic T Cell Defects in Systemic Autoimmunity
KONG PL, ODEGARD JM, BOUZAHZAH F, CHOI J, EARDLEY LD, ZIELINSKI CE, CRAFT JE. Intrinsic T Cell Defects in Systemic Autoimmunity. Annals Of The New York Academy Of Sciences 2003, 987: 60-67. PMID: 12727624, DOI: 10.1111/j.1749-6632.2003.tb06033.x.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusT cell defectsIntrinsic T cell defectCell defectsT cell toleranceLupus pathogenesisLupus erythematosusAutoimmune diseasesSystemic autoimmunityT cellsCell toleranceNuclear antigenGenetic causeLupusBiochemical natureErythematosusAutoimmunityPathogenesisAntigenDiseaseMice