2015
Circulating Follicular Helper–Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity
Choi J, Ho J, Pasoto SG, Bunin V, Kim ST, Carrasco S, Borba EF, Gonçalves CR, Costa PR, Kallas EG, Bonfa E, Craft J. Circulating Follicular Helper–Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity. Arthritis & Rheumatology 2015, 67: 988-999. PMID: 25581113, PMCID: PMC4450082, DOI: 10.1002/art.39020.Peer-Reviewed Original ResearchConceptsTfh-like cellsSLE Disease Activity IndexSystemic lupus erythematosusInducible T-cell costimulatorPD-1 expressionDisease activityT cellsBehçet's diseaseSLE patientsLupus erythematosusBlood samplesT cell-B cell collaborationCentral memory T cellsExpression of CXCR5Disease activity indexGerminal center activityMemory T cellsDeath 1 proteinFollicular helper TT-cell costimulatorActive diseaseAntibody positivityDisease durationFollicular helperIL-21
2006
CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL‐medicated osteoclastogenesis: Evidence of NF‐κB–dependent, CD40‐mediated bone destruction in rheumatoid arthritis
Lee H, Jeon H, Song E, Han M, Park S, Lee S, Yun H, Kim J, Kim J, Lee Y, Kim S, Kim H, Choi J, Kang I, Kim H, Yoo W. CD40 ligation of rheumatoid synovial fibroblasts regulates RANKL‐medicated osteoclastogenesis: Evidence of NF‐κB–dependent, CD40‐mediated bone destruction in rheumatoid arthritis. Arthritis & Rheumatism 2006, 54: 1747-1758. PMID: 16736517, DOI: 10.1002/art.21873.Peer-Reviewed Original ResearchMeSH KeywordsArthritis, RheumatoidCarrier ProteinsCD40 AntigensCells, CulturedFibroblastsHumansI-kappa B KinaseI-kappa B ProteinsMembrane GlycoproteinsMitogen-Activated Protein Kinase 1NF-kappa BNF-KappaB Inhibitor alphaOsteoclastsP38 Mitogen-Activated Protein KinasesRANK LigandReceptor Activator of Nuclear Factor-kappa BReverse Transcriptase Polymerase Chain ReactionSynovial MembraneConceptsRheumatoid arthritis synovial fibroblastsRANKL expressionCD40 ligationSynovial fibroblastsT cellsIkappaB-alphaNF-kappaBPeripheral blood mononuclear cellsTumor necrosis factor alphaTartrate-resistant acid phosphatase (TRAP) stainingERK 1/2CD40-CD40L interactionBlood mononuclear cellsRheumatoid synovial fibroblastsArthritis synovial fibroblastsNecrosis factor alphaP38 MAPKReverse transcription-polymerase chain reactionResorption pit formationNF-kappaB inhibitorTranscription-polymerase chain reactionFormation of osteoclastsNF-kappaB activationAcid phosphatase stainingL cells
2004
Age-associated changes in the frequency of naïve, memory and effector CD8+ T cells
Hong MS, Dan JM, Choi JY, Kang I. Age-associated changes in the frequency of naïve, memory and effector CD8+ T cells. Mechanisms Of Ageing And Development 2004, 125: 615-618. PMID: 15491679, DOI: 10.1016/j.mad.2004.07.001.Peer-Reviewed Original ResearchConceptsAge-associated changesT cell subsetsEffector CD8T cellsCell subsetsFrequencies of naïveFrequency of CD8Expression of CD45RAT cell functionEffector memoryPeripheral bloodCD8CM cellsDecreased frequencyCentral memoryFlow cytometryElderly peopleCell functionSimilar frequencyNaïveCellsCCR7CD45RABloodSubsetAge-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine
Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, Craft J. Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine. The Journal Of Immunology 2004, 173: 673-681. PMID: 15210831, DOI: 10.4049/jimmunol.173.1.673.Peer-Reviewed Original ResearchConceptsT cell responsesIL-7 levelsMemory CD4Long-term CD4T cellsCell responsesInfluenza vaccineIFN-gammaInfluenza virus-specific CD4Serum IL-7 levelsEM cellsLevels of CD4Virus-specific CD4Central memory CD4Effector memory CD4Cellular immune responsesFrequency of influenzaImportant clinical questionsAge-Associated ChangesEM CD4Influenza vaccinationTNF-alphaVaccination strategiesIL-7Immune response
2003
Intrinsic T Cell Defects in Systemic Autoimmunity
KONG PL, ODEGARD JM, BOUZAHZAH F, CHOI J, EARDLEY LD, ZIELINSKI CE, CRAFT JE. Intrinsic T Cell Defects in Systemic Autoimmunity. Annals Of The New York Academy Of Sciences 2003, 987: 60-67. PMID: 12727624, DOI: 10.1111/j.1749-6632.2003.tb06033.x.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusT cell defectsIntrinsic T cell defectCell defectsT cell toleranceLupus pathogenesisLupus erythematosusAutoimmune diseasesSystemic autoimmunityT cellsCell toleranceNuclear antigenGenetic causeLupusBiochemical natureErythematosusAutoimmunityPathogenesisAntigenDiseaseMice