2000
Bcl-2 antisense oligodeoxynucleotide therapy of Epstein-Barr virus-associated lymphoproliferative disease in severe combined immunodeficient mice.
Guinness M, Kenney J, Reiss M, Lacy J. Bcl-2 antisense oligodeoxynucleotide therapy of Epstein-Barr virus-associated lymphoproliferative disease in severe combined immunodeficient mice. Cancer Research 2000, 60: 5354-8. PMID: 11034070.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusPosttransplant lymphoproliferative disorderLymphoproliferative disordersBcl-2 antisenseLymphoproliferative diseaseImmunodeficient miceEpstein-Barr virus-associated lymphoproliferative diseaseBcl-2EBV-positive lymphoproliferative diseaseSequence-dependent antitumor effectsMajority of EBVAntisense oligodeoxynucleotide therapyEBV-positive malignanciesB-cell lymphoproliferationBcl-2 antisense therapyInhibition of proliferationLymphoblastoid B cellsTreatment strategiesChemoprotective effectsAntitumor effectsVitro treatmentB cellsChimeric modelDecreased expressionRational target
1993
PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements
Rupprecht H, Sukhatme V, Lacy J, Sterzel R, Coleman D. PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. American Journal Of Physiology 1993, 265: f351-f360. PMID: 8214093, DOI: 10.1152/ajprenal.1993.265.3.f351.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDNA-Binding ProteinsEarly Growth Response Protein 1Gene ExpressionGlomerular MesangiumImmediate-Early ProteinsMolecular Sequence DataNuclear ProteinsOligonucleotide ProbesPhosphorylationPlatelet-Derived Growth FactorPromoter Regions, GeneticRatsSerum Response FactorTranscription FactorsTranscription, GeneticTyrosineConceptsPlatelet-derived growth factorPDGF stimulationElectrophoretic mobility shift assaysNuclear run-off assaysPromoter deletion analysisEgr-1 transcriptionEarly growth response gene-1Serum response elementUpstream serum response elementsProtein tyrosine phosphorylationMobility shift assaysRun-off assaysResponse gene-1Egr-1 inductionEgr-1 mRNAEgr-1 expressionImmediate early genesTranscriptional inductionDeletion analysisTyrosine phosphorylationShift assaysTranscriptional levelConsensus sequenceTranscription rateGene expression
1990
Interleukin 6 is an autocrine growth factor for mesangial cells
Ruef C, Budde K, Lacy J, Northemann W, Baumann M, Sterzel R, Coleman D. Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney International 1990, 38: 249-257. PMID: 2402117, DOI: 10.1038/ki.1990.193.Peer-Reviewed Original ResearchConceptsIL-6Autocrine growth factorInterleukin-6T cellsGrowth factorSecrete IL-6Possible paracrine roleAcute phase responseIL-6 mRNADose-dependent increaseIL-6 actsMesangial cell proliferationIL-6 resultsGlomerular inflammationNumber of MCsImmune responseRat MCsParacrine roleB cellsMesangial cellsMC-CMEndothelial cellsAutocrine signalsCell proliferationPlasmacytoma cellsMacrophage colony-stimulating factor production by murine and human keratinocytes. Enhancement by bacterial lipopolysaccharide.
Chodakewitz J, Lacy J, Edwards S, Birchall N, Coleman D. Macrophage colony-stimulating factor production by murine and human keratinocytes. Enhancement by bacterial lipopolysaccharide. The Journal Of Immunology 1990, 144: 2190-6. PMID: 2179407, DOI: 10.4049/jimmunol.144.6.2190.Peer-Reviewed Original Research
1989
Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor
Budde K, Coleman D, Lacy J, Sterzel R. Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor. American Journal Of Physiology 1989, 257: f1065-f1078. PMID: 2690641, DOI: 10.1152/ajprenal.1989.257.6.f1065.Peer-Reviewed Original ResearchConceptsRat mesangial cellsGranulocyte-macrophage colony-stimulating factorCultured rat mesangial cellsMesangial cellsColony-stimulating factorGM-CSFMC-CMGlomerular mesangial cellsPeritoneal MPsEffector cellsIL-2Inflammatory processGlomerular diseaseInterleukin-2T cellsT lymphocytesInterleukin-4Murine GM-CSFRenal glomeruliSerum-free conditionsSoluble factorsProliferative activitySpecific cDNA probesGM-CSF mRNA transcriptsPresent findings