1994
Epstein-Barr viral nuclear antigen 1 antisense oligodeoxynucleotide inhibits proliferation of Epstein-Barr virus-immortalized B cells.
Roth G, Curiel T, Lacy J. Epstein-Barr viral nuclear antigen 1 antisense oligodeoxynucleotide inhibits proliferation of Epstein-Barr virus-immortalized B cells. Blood 1994, 84: 582-7. PMID: 8025284, DOI: 10.1182/blood.v84.2.582.bloodjournal842582.Peer-Reviewed Original ResearchConceptsEBNA-1EBNA-1 proteinAntisense oligodeoxynucleotidesEpstein-Barr virus-immortalized B cellsEpstein-Barr virus nuclear antigen 1EBV-negative cellsLatent viral proteinsNuclear antigen 1Potential therapeutic implicationsLymphoblastoid cellsEpisomal viral genomesUnmodified antisense oligodeoxynucleotidesNeoplastic diseaseTherapeutic implicationsB cellsInhibited proliferationEBVEffect of antisenseAntigen 1Antiproliferative effectsProtein expressionUntreated cellsImmortalized cellsViral proteinsProliferationEpstein-Barr Viral Nuclear Antigen 1 Antisense Oligodeoxynucleotide Inhibits Proliferation of Epstein-Barr Virus-Immortalized B Cells
Roth G, Curiel T, Lacy J. Epstein-Barr Viral Nuclear Antigen 1 Antisense Oligodeoxynucleotide Inhibits Proliferation of Epstein-Barr Virus-Immortalized B Cells. Blood 1994, 84: 582-587. DOI: 10.1182/blood.v84.2.582.582.Peer-Reviewed Original ResearchEBNA-1EBNA-1 proteinAntisense oligodeoxynucleotidesEpstein-Barr virus nuclear antigen 1EBV-negative cellsEpstein-Barr virusLatent viral proteinsNuclear antigen 1Potential therapeutic implicationsLymphoblastoid cellsImmortalized B cellsEpisomal viral genomesUnmodified antisense oligodeoxynucleotidesNeoplastic diseaseTherapeutic implicationsB cellsInhibited proliferationInhibits proliferationEBVEffect of antisenseAntigen 1Antiproliferative effectsProtein expressionUntreated cellsImmortalized cells
1991
Conversion of a human B cell lymphoma line by Epstein-Barr virus is associated with increased tyrosine phosphorylation of a 50 kilodalton cytosolic protein
Lacy J, Bartiss A, Coleman D. Conversion of a human B cell lymphoma line by Epstein-Barr virus is associated with increased tyrosine phosphorylation of a 50 kilodalton cytosolic protein. Virus Research 1991, 20: 85-96. PMID: 1656626, DOI: 10.1016/0168-1702(91)90063-2.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusB cellsHuman B cellsB-cell lymphoma linePresence of EBVLymphoma linesProtein tyrosine phosphorylationEBV infectionHuman B cell lymphoma lineTyrosine phosphorylationB lymphocytesImmortalized lymphoblastoid cellsBiochemical changesLymphoblastoid cellsInfectionEndogenous tyrosine kinasesContinuous proliferationCytosolic proteinsTyrosine kinaseVirusCellsPhosphorylationPhosphotyrosine antibodiesLymphocytesProtein