2023
Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex
Rompala G, Nagamatsu S, Martínez-Magaña J, Nuñez-Ríos D, Wang J, Girgenti M, Krystal J, Gelernter J, Hurd Y, Montalvo-Ortiz J. Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex. Nature Communications 2023, 14: 4544. PMID: 37507366, PMCID: PMC10382503, DOI: 10.1038/s41467-023-40285-y.Peer-Reviewed Original ResearchConceptsOpioid use disorderMulti-omics findingsGene expression patternsCo-methylation analysisGene expression profilesMulti-omics profilingGene networksDNA methylationNeuronal methylomesDNA hydroxymethylationMethylomic analysisExpression patternsExpression profilesEpigenetic disturbancesUse disordersPsychiatric traitsOrbitofrontal cortexOpioid-related drugsPostmortem orbitofrontal cortexEnvironmental factorsDrug interaction analysisOUD treatmentHuman orbitofrontal cortexOpioid signalingInteraction analysis
2019
Dependency of the Cancer-Specific Transcriptional Regulation Circuitry on the Promoter DNA Methylome
Liu Y, Liu Y, Huang R, Song W, Wang J, Xiao Z, Dong S, Yang Y, Yang X. Dependency of the Cancer-Specific Transcriptional Regulation Circuitry on the Promoter DNA Methylome. Cell Reports 2019, 26: 3461-3474.e5. PMID: 30893615, DOI: 10.1016/j.celrep.2019.02.084.Peer-Reviewed Original ResearchConceptsDNA methylomeTranscription factorsTranscriptional regulation circuitsCpG sitesGene expression dysregulationIntegrative analysis pipelineCpG methylation profilesSignature of cancerRegulation machineryExpression regulationCancer Genome AtlasCancer-related genesGene expression abnormalitiesExpression dysregulationMethylation profilesMethylomeDynamic dysregulationPhysiological relevanceGenome AtlasExpression abnormalitiesAnalysis pipelineRegulation circuitCancer typesDysregulationComprehensive understanding