2019
Regulation of substrate utilization and adiposity by Agrp neurons
Cavalcanti-de-Albuquerque JP, Bober J, Zimmer MR, Dietrich MO. Regulation of substrate utilization and adiposity by Agrp neurons. Nature Communications 2019, 10: 311. PMID: 30659173, PMCID: PMC6338802, DOI: 10.1038/s41467-018-08239-x.Peer-Reviewed Original ResearchConceptsFat mass accumulationAgRP neuronsPositive energy balanceWhole-body substrate utilizationAgRP neuron activationHypothalamic AgRP neuronsPair-feeding conditionsSubstrate utilizationFatty acid synthaseCaloric ingestionFat utilizationNeuronal mechanismsWeight gainNeuronsMetabolic changesMass accumulationKey enzymeAdiposityAcid synthaseEnergy metabolismNeuron activationLipogenesisActivationCarbohydrate utilizationMetabolic efficiency
2017
Puberty is an important developmental period for the establishment of adipose tissue mass and metabolic homeostasis
Holtrup B, Church CD, Berry R, Colman L, Jeffery E, Bober J, Rodeheffer MS. Puberty is an important developmental period for the establishment of adipose tissue mass and metabolic homeostasis. Adipocyte 2017, 6: 224-233. PMID: 28792785, PMCID: PMC5638358, DOI: 10.1080/21623945.2017.1349042.Peer-Reviewed Original ResearchConceptsChildhood obesityMetabolic dysfunctionMetabolic homeostasisObesogenic stimuliExposure of miceHigh-fat dietAdipose tissue functionAdipose tissue massPostnatal day 18White adipose tissueType II diabetesCritical developmental periodAdipose massFat dietLeptin expressionAdipocyte sizeFat massDiabetic phenotypeObesityTissue massAdipose tissueBody weightDay 18II diabetesAdipose functionHypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding
Dietrich MO, Zimmer MR, Bober J, Horvath TL. Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding. Cell 2017, 169: 559. PMID: 28431254, DOI: 10.1016/j.cell.2017.04.006.Peer-Reviewed Original Research
2015
Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding
Dietrich MO, Zimmer MR, Bober J, Horvath TL. Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding. Cell 2015, 160: 1222-1232. PMID: 25748653, PMCID: PMC4484787, DOI: 10.1016/j.cell.2015.02.024.Peer-Reviewed Original ResearchConceptsHypothalamic AgRP neuronsAgRP neuronsNeuropeptidergic signalingReceptor signalingFunctional rolePotential therapeutic avenuesAgRP neuron activationStereotypic behaviorFeeding behaviorRepetitive behaviorsSignalingTherapeutic avenuesFood triggersAdult miceNervous systemDecreased anxietyNeuronsMinor effectActivationFood consumptionNeuron activationGoal-directed behaviorSensory informationFlexible goal-directed behaviorDisease
2012
AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors
Dietrich MO, Bober J, Ferreira JG, Tellez LA, Mineur YS, Souza DO, Gao XB, Picciotto MR, Araújo I, Liu ZW, Horvath TL. AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nature Neuroscience 2012, 15: 1108-1110. PMID: 22729177, PMCID: PMC3411867, DOI: 10.1038/nn.3147.Peer-Reviewed Original Research
2010
Effects of Estradiol on Learned Helplessness and Associated Remodeling of Hippocampal Spine Synapses in Female Rats
Hajszan T, Szigeti-Buck K, Sallam NL, Bober J, Parducz A, MacLusky NJ, Leranth C, Duman RS. Effects of Estradiol on Learned Helplessness and Associated Remodeling of Hippocampal Spine Synapses in Female Rats. Biological Psychiatry 2010, 67: 168-174. PMID: 19811775, PMCID: PMC2794927, DOI: 10.1016/j.biopsych.2009.08.017.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBehavior, AnimalCA1 Region, HippocampalDendritic SpinesDisease Models, AnimalElectroshockEscape ReactionEstradiolEstrogensFemaleHelplessness, LearnedMicroscopy, Electron, TransmissionNeuronsOvariectomyRatsRats, Sprague-DawleyRegression AnalysisStereotaxic TechniquesStress, PsychologicalSynapsesTime FactorsConceptsHippocampal spine synapsesSpine synapsesHelpless behaviorFemale ratsSpine synapse numberNeurobiology of depressionOvariectomized female ratsEffects of estradiolPresence of estradiolElectron microscopic stereologySynaptic lossSubchronic treatmentEstradiol exposureEstradiol supplementationFemale reproductive lifeNonstressed animalsSynaptic responsesSynaptogenic effectsDepression neurobiologyMale ratsSynapse numberAntidepressant desipramineEscape testingSynapse remodelingSignificant negative correlation
2009
Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain
Markakis EA, Vives KP, Bober J, Leichtle S, Leranth C, Beecham J, Elsworth JD, Roth RH, Samulski RJ, Redmond DE. Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain. Molecular Therapy 2009, 18: 588-593. PMID: 20010918, PMCID: PMC2839442, DOI: 10.1038/mt.2009.286.Peer-Reviewed Original ResearchConceptsSubstantia nigraPrimate brainCaudate nucleusSerotype 1Central nervous systemProtein-positive cellsAAV serotype 2Long-term transductionNigrostriatal systemClinical trialsPositive cellsNervous systemUnbiased stereologyVector injectionComparable titersNeural cellsBrainTransduction efficiencySerotype 2Vector transduction efficiencyTherapeutic transgenesViral vectorsNigraEnhanced green fluorescent protein (EGFP) reporter geneAAV vectors
2008
Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates
Leranth C, Hajszan T, Szigeti-Buck K, Bober J, MacLusky NJ. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14187-14191. PMID: 18768812, PMCID: PMC2544599, DOI: 10.1073/pnas.0806139105.Peer-Reviewed Original ResearchConceptsSpine synapse formationNonhuman primate modelSynapse formationPrimate modelAbility of BPAPrefrontal cortexOvariectomized nonhuman primatesLimbic brain areasHuman BPA exposureRodent animal modelsLow exposure levelsBPA administrationDaily doseMale ratsSpine synapsesBPA exposureAnimal modelsBrain areasSynthetic xenoestrogenCognitive functionNonhuman primatesAdverse effectsExposure levelsPolycarbonate plasticsExposure measurements
2006
Efficiency of gene delivery among AAV serotypes in primate brain
Markakis E, Leranth C, Bober J, Samulski R, Rabinowitz J, Zhou X, Vives K, Redmond D. Efficiency of gene delivery among AAV serotypes in primate brain. Experimental Neurology 2006, 198: 580-581. DOI: 10.1016/j.expneurol.2006.02.071.Peer-Reviewed Original Research113. Transduction of Neural Cells in Primate Brain Using Adeno-Associated Virus (AAV) Serotypes 2 and 5
Markakis E, Leranth C, Bober J, Samulski R, Rabinowitz J, Zhou X, Vives K, Redmond D. 113. Transduction of Neural Cells in Primate Brain Using Adeno-Associated Virus (AAV) Serotypes 2 and 5. Molecular Therapy 2006, 13: s46-s47. DOI: 10.1016/j.ymthe.2006.08.133.Peer-Reviewed Original Research