2022
Clinical Outcomes at 1 Year Following Transcatheter Left Atrial Appendage Occlusion in the United States
Price MJ, Slotwiner D, Du C, Freeman JV, Turi Z, Rammohan C, Kusumoto FM, Kavinsky C, Akar J, Varosy PD, Koutras C, Curtis JP, Masoudi FA. Clinical Outcomes at 1 Year Following Transcatheter Left Atrial Appendage Occlusion in the United States. JACC Cardiovascular Interventions 2022, 15: 741-750. PMID: 35393108, PMCID: PMC9116488, DOI: 10.1016/j.jcin.2022.02.009.Peer-Reviewed Original ResearchConceptsAtrial appendage occlusionIschemic strokeMajor bleedingClinical outcomesSystemic embolismAppendage occlusionMean HAS-BLED scoreHAS-BLED scoreKey secondary endpointKaplan-Meier methodCumulative event rateRate of mortalityMean CHAPrior strokeRelevant bleedingVASc scoreWATCHMAN procedurePrimary endpointSecondary endpointsThromboembolic eventsIntracranial bleedingBlood transfusionHemoglobin levelsHemorrhagic strokeKaplan-Meier
2020
Comparison of left ventricular lead upgrade vs continued medical care among patients eligible for cardiac resynchronization therapy at the time of defibrillator generator replacement: Predictors of left ventricular lead upgrade and associations with long-term outcomes
Hyman MC, Bao H, Curtis JP, Minges K, Schaller RD, Birgersdotter-Green U, Marchlinski FE, Hsu JC. Comparison of left ventricular lead upgrade vs continued medical care among patients eligible for cardiac resynchronization therapy at the time of defibrillator generator replacement: Predictors of left ventricular lead upgrade and associations with long-term outcomes. Heart Rhythm 2020, 17: 1878-1886. PMID: 32497762, DOI: 10.1016/j.hrthm.2020.05.032.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyCRT-eligible patientsCRT upgradeResynchronization therapyClinical outcomesNational Cardiovascular Data Registry ICD RegistryGenerator replacementPeriprocedural complication rateLeft ventricular leadSubpopulation of patientsLong-term outcomesICD generator replacementHierarchical logistic regression modelsLogistic regression modelsSecondary endpointsCause mortalityPrimary endpointComplication rateICD RegistryProcedural complicationsMedical managementICD populationNational registryVentricular leadClaims data
2019
Myocardial infarction with non-obstructive coronary arteries as compared with myocardial infarction and obstructive coronary disease: outcomes in a Medicare population
Dreyer RP, Tavella R, Curtis JP, Wang Y, Pauspathy S, Messenger J, Rumsfeld JS, Maddox TM, Krumholz HM, Spertus JA, Beltrame JF. Myocardial infarction with non-obstructive coronary arteries as compared with myocardial infarction and obstructive coronary disease: outcomes in a Medicare population. European Heart Journal 2019, 41: 870-878. PMID: 31222249, PMCID: PMC7778433, DOI: 10.1093/eurheartj/ehz403.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsAcute myocardial infarctionHeart failureMyocardial infarctionCoronary angiographyComponents of MACENational Cardiovascular Data Registry CathPCI RegistryNon-obstructive coronary arteriesObstructive coronary artery diseaseAdverse cardiac eventsMajor adverse eventsObservational cohort studyObstructive coronary diseasePrognosis of patientsCoronary artery diseaseMACE componentsMINOCA patientsAdjusted riskCause mortalityPrimary endpointSecondary endpointsAdverse eventsCardiac eventsCathPCI RegistryCohort study
2015
Comparative Effectiveness of CRT-D Versus Defibrillator Alone in HF Patients With Moderate-to-Severe Chronic Kidney Disease
Friedman DJ, Singh JP, Curtis JP, Tang WHW, Bao H, Spatz ES, Hernandez AF, Patel UD, Al-Khatib SM. Comparative Effectiveness of CRT-D Versus Defibrillator Alone in HF Patients With Moderate-to-Severe Chronic Kidney Disease. Journal Of The American College Of Cardiology 2015, 66: 2618-2629. PMID: 26670062, DOI: 10.1016/j.jacc.2015.09.097.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac Resynchronization TherapyComorbidityComparative Effectiveness ResearchDefibrillators, ImplantableElectric CountershockFemaleGlomerular Filtration RateHeart FailureHospitalizationHumansMaleMedicareProportional Hazards ModelsRenal Insufficiency, ChronicSeverity of Illness IndexSurvival AnalysisTreatment OutcomeUnited StatesConceptsSevere chronic kidney diseaseChronic kidney diseaseCardiac resynchronization therapyCRT-eligible patientsHF hospitalizationKidney diseaseNational Cardiovascular Data Registry ICD RegistryUse of CRTComparative effectivenessInverse probability-weighted analysisReal-world comparative effectivenessEnd-stage renal diseaseCox proportional hazards modelCRT-D useHeart failure hospitalizationAcceptable complication rateDevice-related complicationsProportional hazards modelFine-Gray modelCKD classCKD stageFailure hospitalizationHF patientsPrimary endpointSecondary endpoints