p53 binding sites in normal and cancer cells are characterized by distinct chromatin context
Bao F, LoVerso PR, Fisk JN, Zhurkin VB, Cui F. p53 binding sites in normal and cancer cells are characterized by distinct chromatin context. Cell Cycle 2017, 16: 2073-2085. PMID: 28820292, PMCID: PMC5731425, DOI: 10.1080/15384101.2017.1361064.Peer-Reviewed Original ResearchConceptsP53 binding siteHistone marksTranscription factorsDNA-binding transcription factorsP53 sitesCancer cellsRepressive histone marksContext of chromatinActive histone marksDistinct epigenetic featuresPioneer transcription factorsHigh nucleosome occupancyP53-DNA interactionsEndogenous retroviral elementsBinding sitesSequence-dependent mannerChromatin environmentChromatin contextNucleosome occupancyTranscriptional networksRepeat familyCognate sitesDNA methylationEpigenetic featuresP53 interacts