Anchorage dependence of mitogen-induced G1 to S transition in primary T lymphocytes.
Geginat J, Bossi G, Bender J, Pardi R. Anchorage dependence of mitogen-induced G1 to S transition in primary T lymphocytes. The Journal Of Immunology 1999, 162: 5085-93. PMID: 10227977, DOI: 10.4049/jimmunol.162.9.5085.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalCalcium-Calmodulin-Dependent Protein KinasesCell AdhesionCell CycleCell Cycle ProteinsCell SizeCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Cyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent KinasesDown-RegulationEnzyme ActivationG1 PhaseGene Expression RegulationGenes, fosGenes, junHumansInterleukin-2InterphaseKineticsLymphocyte Function-Associated Antigen-1Microtubule-Associated ProteinsMitogensProtein Serine-Threonine KinasesProto-Oncogene ProteinsReceptors, Antigen, T-CellS PhaseT-LymphocytesTumor Suppressor ProteinsConceptsNormal T cellsT lymphocytesT cellsPrimary T lymphocytesRetinoblastoma protein inactivationCytokines IL-2Function-blocking mAbsIL-2ICAM-1Mitogen-activated protein kinase activationCyclin-dependent kinase inhibitor p27kipIntegrins actMitogenic responseMitogenic cytokinesGrowth factorLymphocytesCell cycle progressionTCR stimulationLate componentsProtein kinase activationLeukocyte integrinsAnchorage dependenceTCR triggeringCycle progressionCellular requirementsA MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2
Liu Y, Pan J, Zhang C, Fan W, Collinge M, Bender J, Weissman S. A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 4313-4318. PMID: 10200259, PMCID: PMC16329, DOI: 10.1073/pnas.96.8.4313.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceB-LymphocytesCalcium-Binding ProteinsCarrier ProteinsCell Cycle ProteinsCell LineChromosomes, Artificial, YeastCOS CellsGenes, MHC Class IHL-60 CellsHumansJurkat CellsMad2 ProteinsMolecular Sequence DataPolymerase Chain ReactionRepressor ProteinsSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionTumor Cells, CulturedUbiquitinsConceptsSpindle assembly checkpoint protein Mad2Two-hybrid screeningCheckpoint protein Mad2Ubiquitin-like proteinHuman MHC class I regionCell cycle checkpointsMHC class I regionSpindle assemblyI geneProtein stabilityCell developmentDendritic cell developmentClass I regionImmunoprecipitation studiesCell growthMad2Gamma-interferon inductionProteinProtein expressionFAT10I regionCellsLymphoblastoid linesAnaphaseTranscription