2021
Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function
Thompson B, Chen Y, Davidson EA, Garcia-Milian R, Golla JP, Apostolopoulos N, Orlicky DJ, Schey K, Thompson DC, Vasiliou V. Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function. The Ocular Surface 2021, 22: 190-203. PMID: 34425299, PMCID: PMC8560581, DOI: 10.1016/j.jtos.2021.08.010.Peer-Reviewed Original ResearchConceptsHEK293T cellsEye developmentGSH biosynthesisTransactivation activityPax6 functionReactive oxygen speciesSubsequent gene ontologyCell identity genesButhionine sulfoximineEpithelial cell identityRNA-seq analysisIngenuity Pathway AnalysisKey upstream regulatorIdentity genesCell identityGene OntologyRNA-seqImmune response genesBioinformatics analysisResponse genesGlutathione biosynthesisLens morphogenesisMolecular consequencesUpstream regulatorMicrophthalmia phenotype
2020
Science of superstimulation
Golla JP, Golla SK, Shelling AN. Science of superstimulation. Fertility And Sterility 2020, 114: 504-505. PMID: 32912611, DOI: 10.1016/j.fertnstert.2020.07.015.Peer-Reviewed Original Research
2019
Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells
Charkoftaki G, Thompson DC, Golla JP, Garcia-Milian R, Lam TT, Engel J, Vasiliou V. Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells. Chemico-Biological Interactions 2019, 304: 88-96. PMID: 30851239, PMCID: PMC7988342, DOI: 10.1016/j.cbi.2019.02.030.Peer-Reviewed Original Research
2014
Carboxylation of cytosine (5caC) in the CG dinucleotide in the E-box motif (CGCAG|GTG) increases binding of the Tcf3|Ascl1 helix-loop-helix heterodimer 10-fold
Golla JP, Zhao J, Mann IK, Sayeed SK, Mandal A, Rose RB, Vinson C. Carboxylation of cytosine (5caC) in the CG dinucleotide in the E-box motif (CGCAG|GTG) increases binding of the Tcf3|Ascl1 helix-loop-helix heterodimer 10-fold. Biochemical And Biophysical Research Communications 2014, 449: 248-255. PMID: 24835951, PMCID: PMC6258048, DOI: 10.1016/j.bbrc.2014.05.018.Peer-Reviewed Original Research
2011
Mutational analysis of JAG1 gene in non-syndromic Tetralogy of Fallot children
Kola S, Koneti NR, Golla JP, Akka J, Gundimeda SD, Mundluru HP. Mutational analysis of JAG1 gene in non-syndromic Tetralogy of Fallot children. Clinica Chimica Acta 2011, 412: 2232-2236. PMID: 21893051, DOI: 10.1016/j.cca.2011.08.017.Peer-Reviewed Original ResearchConceptsTetralogy of FallotTOF patientsRight ventricular outflow tract obstructionVentricular outflow tract obstructionJAG1 geneRight-sided heart diseaseOutflow tract obstructionSided heart diseaseRight ventricular hypertrophyVentricular septal defectSecond epidermal growth factorCell fate decisionsInter-species conservationNon-syndromic tetralogyCell-cell interactionsBidirectional DNA sequencingAortic dextropositionFallot childrenTract obstructionVentricular hypertrophySeptal defectFate decisionsHealthy controlsHeart diseaseIndian cohort