2023
Biomarkers for acute kidney injury in children – where are we now?
Sandokji I, Greenberg J. Biomarkers for acute kidney injury in children – where are we now? Current Opinion In Pediatrics 2023, 35: 245-250. PMID: 36601976, DOI: 10.1097/mop.0000000000001217.Peer-Reviewed Original ResearchConceptsAcute kidney injuryNeutrophil gelatinase-associated lipocalinUrine neutrophil gelatinase-associated lipocalinInsulin-like growth factor binding protein 7AKI biomarkersKidney injuryGrowth factor binding protein 7AKI risk stratificationUrine tissue inhibitorGelatinase-associated lipocalinBest discriminative valueBinding protein 7Early time pointsTubular injuryRisk stratificationTissue inhibitorDiagnostic biomarkersClinical modelMetalloproteinases 2Discriminative valueBiomarkersInjuryTime pointsProtein 7Modest improvement
2021
Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children
Greenberg JH, Abraham AG, Xu Y, Schelling JR, Feldman HI, Sabbisetti VS, Ix JH, Jogalekar MP, Coca S, Waikar SS, Shlipak MG, Warady BA, Vasan RS, Kimmel PL, Bonventre JV, Denburg M, Parikh CR, Furth S, Consortium O. Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children. Journal Of The American Society Of Nephrology 2021, 32: 2664-2677. PMID: 34544821, PMCID: PMC8722795, DOI: 10.1681/asn.2021010094.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlbuminuriaAlpha-GlobulinsBiomarkersChemokine CCL2ChildChitinase-3-Like Protein 1CreatinineDisease ProgressionEpidermal Growth FactorFemaleFollow-Up StudiesGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansKidney TubulesMaleNephritisProspective StudiesRenal Insufficiency, ChronicConceptsUrine KIM-1CKD progressionUrine biomarkersMicroglobulin concentrationsHighest quartileKIM-1MCP-1High riskRapid kidney function declineBiomarker concentrationsEGF concentrationsKidney tubule healthNovel urine biomarkersUrine biomarker concentrationsKidney function declineProgression of CKDUrine creatinine concentrationIdentification of childrenTubular healthMultivariable adjustmentComposite outcomeTubular injuryPrimary outcomeFunction declineStudy enrollment