2024
Long-Term Kidney Outcomes after Pediatric Acute Kidney Injury
Robinson C, Jeyakumar N, Luo B, Askenazi D, Deep A, Garg A, Goldstein S, Greenberg J, Mammen C, Nash D, Parekh R, Silver S, Thabane L, Wald R, Zappitelli M, Chanchlani R. Long-Term Kidney Outcomes after Pediatric Acute Kidney Injury. Journal Of The American Society Of Nephrology 2024, 35: 1520-1532. PMID: 39018120, PMCID: PMC11543010, DOI: 10.1681/asn.0000000000000445.Peer-Reviewed Original ResearchAcute kidney replacement therapyAcute kidney injuryKidney replacement therapyLong-term kidney replacement therapyChronic kidney diseasePediatric acute kidney injuryHospital CompareAcute kidney injury survivorsKidney injuryProvincial administrative health databasesLong-term chronic kidney diseaseLong-term risk of chronic kidney diseaseLong-term kidney outcomesMajor Adverse Kidney EventsHospitalized childrenAdministrative health databasesRisk of chronic kidney diseaseIntensive care unit admissionIncident chronic kidney diseaseAdverse kidney eventsRetrospective cohort studyPediatric AKI survivorsLong-term riskNeonatal statusPropensity score matching
2023
Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study
de Fontnouvelle C, Zappitelli M, Thiessen-Philbrook H, Jia Y, Kimmel P, Kaufman J, Devarajan P, Parikh C, Greenberg J. Biomarkers of eGFR decline after cardiac surgery in children: findings from the ASSESS-AKI study. Pediatric Nephrology 2023, 38: 2851-2860. PMID: 36790467, DOI: 10.1007/s00467-023-05886-1.Peer-Reviewed Original ResearchConceptsCyanotic heart diseaseChronic kidney diseaseEGFR declineCardiac surgeryHeart diseaseUrine uromodulinMedian eGFRIL-18Study visitGraphical abstractA higher resolution versionLong-term chronic kidney diseaseGlomerular filtration rate declineFaster eGFR declineIL-18 concentrationsLower median eGFRSurgical complexity scoreAcyanotic heart diseaseCongenital heart diseaseSubgroup of childrenTubular healthOverall cohortClinical factorsUrine biomarkersKidney diseaseUrinary biomarkers