2001
Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal
Akbarian S, Bates B, Liu R, Skirboll S, Pejchal T, Coppola V, Sun L, Fan G, Kucera J, Wilson M, Tessarollo L, Kosofsky B, Taylor J, Bothwell M, Nestler E, Aghajanian G, Jaenisch R. Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal. Molecular Psychiatry 2001, 6: 593-604. PMID: 11526474, DOI: 10.1038/sj.mp.4000897.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAvoidance LearningBrainColforsinCyclic AMPElectric StimulationEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Gene Expression Regulation, EnzymologicIn Vitro TechniquesIntermediate Filament ProteinsLocus CoeruleusMiceMice, KnockoutMice, TransgenicMorphineMorphine DependenceNerve Tissue ProteinsNestinNeuronsNeurotrophin 3Signal TransductionSubstance Withdrawal SyndromeTyrosine 3-MonooxygenaseConceptsNoradrenergic neuronsNeurotrophin-3NT-3Opiate withdrawalNoradrenergic signalingOpiate withdrawal symptomsChronic morphine exposureNT-3 expressionNon-catecholaminergic neuronsLoss of neuronsDorsal medullaMorphine exposureWithdrawal symptomsAfferent sourcesTyrosine hydroxylaseAdult brainSomatic symptomsNeuron functionVentral forebrainConditional ablationReduced upregulationNeuronsAltered cAMPSymptomsWithdrawal
1998
A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the rat
Taylor J, Punch L, Elsworth J. A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the rat. Psychopharmacology 1998, 138: 133-142. PMID: 9718282, DOI: 10.1007/s002130050655.Peer-Reviewed Original Research
1997
Opposite Modulation of Opiate Withdrawal Behaviors on Microinfusion of a Protein Kinase A Inhibitor Versus Activator into the Locus Coeruleus or Periaqueductal Gray
Punch L, Self D, Nestler E, Taylor J. Opposite Modulation of Opiate Withdrawal Behaviors on Microinfusion of a Protein Kinase A Inhibitor Versus Activator into the Locus Coeruleus or Periaqueductal Gray. Journal Of Neuroscience 1997, 17: 8520-8527. PMID: 9334424, PMCID: PMC6573752, DOI: 10.1523/jneurosci.17-21-08520.1997.Peer-Reviewed Original ResearchAmygdalaAnimalsBehavior, AnimalCyclic AMPCyclic AMP-Dependent Protein KinasesEnzyme InhibitorsInfusions, ParenteralLocus CoeruleusMaleMorphine DependenceMotor ActivityNaloxoneNarcotic AntagonistsNerve Tissue ProteinsPeriaqueductal GrayPhosphorylationProtein Processing, Post-TranslationalRatsRats, Sprague-DawleySecond Messenger SystemsStereotyped BehaviorSubstance Withdrawal SyndromeThionucleotidesTyrosine 3-Monooxygenase
1988
Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal
Taylor J, Elsworth J, Garcia E, Grant S, Roth R, Redmond D. Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal. Psychopharmacology 1988, 96: 121-134. PMID: 3147472, DOI: 10.1007/bf02431544.Peer-Reviewed Original ResearchConceptsNaloxone-precipitated withdrawalDorsal parabrachial nucleusAlpha-2 adrenergic receptorsWet dog shakesLocus coeruleusClonidine infusionMHPG concentrationsOpiate withdrawalAlpha-2 adrenergic agonistsAnti-withdrawal actionWithdrawal-induced increasesBlood-brain barrierInfusion of clonidineNucleus locus coeruleusOccurrence of diarrheaClonidine's abilityLC infusionBrain concentrationsNoradrenergic neuronsST-91MHPG levelsPeripheral injectionWithdrawal signsNeurochemical changesParabrachial nucleus