2008
Acute Hippocampal Brain-Derived Neurotrophic Factor Restores Motivational and Forced Swim Performance After Corticosterone
Gourley SL, Kiraly DD, Howell JL, Olausson P, Taylor JR. Acute Hippocampal Brain-Derived Neurotrophic Factor Restores Motivational and Forced Swim Performance After Corticosterone. Biological Psychiatry 2008, 64: 884-890. PMID: 18675955, PMCID: PMC2633780, DOI: 10.1016/j.biopsych.2008.06.016.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorHippocampal brain-derived neurotrophic factorAntidepressant treatmentCORT exposureCORT secretionAppetitive instrumental behaviorChronic antidepressant treatmentDepressive-like stateNeurobiology of depressionHippocampal BDNF expressionAdult male miceAnhedonic-like behaviorResponse Element-Binding Protein PhosphorylationCAMP response element-binding protein (CREB) phosphorylationProgressive ratio taskElement-Binding Protein PhosphorylationADT efficacyCORT modelAntidepressant efficacyBDNF expressionHippocampal brainNeurotrophic factorSwim testCorticosterone exposureMale mice
2007
Regionally Specific Regulation of ERK MAP Kinase in a Model of Antidepressant-Sensitive Chronic Depression
Gourley SL, Wu FJ, Kiraly DD, Ploski JE, Kedves AT, Duman RS, Taylor JR. Regionally Specific Regulation of ERK MAP Kinase in a Model of Antidepressant-Sensitive Chronic Depression. Biological Psychiatry 2007, 63: 353-359. PMID: 17889834, PMCID: PMC2277331, DOI: 10.1016/j.biopsych.2007.07.016.Peer-Reviewed Original ResearchMeSH KeywordsAmitriptylineAnimalsAntidepressive Agents, TricyclicAnti-Inflammatory AgentsChronic DiseaseConditioning, OperantCorticosteroneCREB-Binding ProteinDentate GyrusDepressive Disorder, MajorDisease Models, AnimalEndoplasmic Reticulum Chaperone BiPExtracellular Signal-Regulated MAP KinasesFluoxetineHeat-Shock ProteinsHippocampusLocomotionMiceMice, Inbred C57BLMolecular ChaperonesMotivationSelective Serotonin Reuptake InhibitorsConceptsAntidepressant efficacyChronic corticosteroneDentate gyrusChronic depressionCA1/CA3Depression-like behaviorExtracellular signal-regulated kinase 1/2Response element-binding proteinSignal-regulated kinase 1/2Amitriptyline treatmentGlucocorticoid exposureADT treatmentNaive rodentsBehavioral despairLong-term consequencesTail suspensionElement-binding proteinCyclic adenosine monophosphateBiochemical measuresERK MAP kinasePrefrontal cortexHeat shock proteinsOperant conditioning taskCommon mediatorPERK1/2