2023
684. Characteristics of Patients with Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences
Guh A, Li R, Korhonen L, Winston L, Parker E, Czaja C, Johnston H, Basiliere E, Meek J, Olson D, Fridkin S, Wilson L, Perlmutter R, Holzbauer S, D’Heilly P, Phipps E, Flores K, Dumyati G, Pierce R, Ocampo V, Wilson C, Watkins J, Gerding D, McDonald L. 684. Characteristics of Patients with Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences. Open Forum Infectious Diseases 2023, 10: ofad500.746. PMCID: PMC10677783, DOI: 10.1093/ofid/ofad500.746.Peer-Reviewed Original ResearchEmerging Infections ProgramClostridioides difficile infectionInitial Clostridioides difficile infectionInitial CDICharacteristics of patientsRecurrent CDIPositive testNitrofurantoin useRecent hospitalizationDifficile infectionPrevention's Emerging Infections ProgramRecurrent Clostridioides difficile infectionMultivariable logistic regression modelMultiple recurrent CDIPrevious positive testTime of presentationFull chart reviewGrant/research supportPrior positive testLogistic regression modelsRace/ethnicityChronic hemodialysisAdjunctive therapyChart reviewConclusions Patients
2022
2314. Hospitalizations and Antibiotic Use in the Year Prior to an Incident C. difficile Infection for Medicare Beneficiaries in Four States, 2016–2018
Hatfield K, Baggs J, Reddy S, Aranmolate R, Meek J, Fridkin S, Szydlowski J, Hatwar T, Dumyati G, Watkins J, Wilson C, McDonald L, Jernigan J, Guh A. 2314. Hospitalizations and Antibiotic Use in the Year Prior to an Incident C. difficile Infection for Medicare Beneficiaries in Four States, 2016–2018. Open Forum Infectious Diseases 2022, 9: ofac492.146. PMCID: PMC9752406, DOI: 10.1093/ofid/ofac492.146.Peer-Reviewed Original ResearchOutpatient antibiotic useEmerging Infections ProgramClostridioides difficile infectionAntibiotic useCDI casesDifficile infectionRisk factorsMedicare beneficiariesPrevention's Emerging Infections ProgramAntibiotic classesPrior yearAntibiotic stewardship effortsC. difficile infectionMultiple risk factorsInpatient hospitalization dataMedicare Provider AnalysisTiming of hospitalizationGrant/research supportDifferent antibiotic classesAntibiotic prescriptionsCase patientsMedian lengthOutpatient antibioticsCDI surveillanceCDI diagnosis
2021
Surveillance of Candidemia in Connecticut: An Epidemiological Comparison Between Two Periods
Gleason-Vergados J, Banach D, Clogher P, Meek J. Surveillance of Candidemia in Connecticut: An Epidemiological Comparison Between Two Periods. Antimicrobial Stewardship & Healthcare Epidemiology 2021, 1: s79-s80. PMCID: PMC9551423, DOI: 10.1017/ash.2021.156.Peer-Reviewed Original ResearchEmerging Infections ProgramEpidemiology of candidemiaCentral venous cathetersCommunity-onset infectionsVenous cathetersBlood culturesConnecticut residentsCDC's Emerging Infections ProgramCommon bloodstream infectionState-wide surveillanceExtended hospital stayIntravenous drug useAttributable mortality rateLength of stayPositive blood culturesCase report formsHigh treatment costsCandidemia managementCandidemia episodesHospital stayRecent surgeryPatient demographicsHospitalized patientsSignificant morbidityBloodstream infections
2018
482. Association between Socioeconomic Status Factors and Incidence of Community-Associated Clostridium difficile Infection Utilizing Factor Analysis—United States, 2014–2015
Skrobarcek K, Mu Y, Ahern J, Beldavs Z, Brousseau G, Dumyati G, Farley M, Holzbauer S, Kainer M, Meek J, Perlmutter R, Phipps E, Winston L, Guh A. 482. Association between Socioeconomic Status Factors and Incidence of Community-Associated Clostridium difficile Infection Utilizing Factor Analysis—United States, 2014–2015. Open Forum Infectious Diseases 2018, 5: s179-s179. PMCID: PMC6253049, DOI: 10.1093/ofid/ofy210.491.Peer-Reviewed Original ResearchClostridium difficile infectionEmerging Infections ProgramSocioeconomic status factorsCDC's Emerging Infections ProgramCA-CDI casesCDI risk factorsSES variablesDays of hospitalizationHealthcare-associated infectionsLow-income areasStatus factorsLow incomeMultivariable analysisCA-CDICDI surveillanceDifficile infectionRisk factorsIncidence rateInfections ProgramPositive testPrevention strategiesCensus tractsHealth disparitiesSocial determinantsHealth resources492. Long-Term Outcomes of Clostridium difficile Infection Among Medicare Beneficiaries
Hatfield K, Baggs J, Winston L, Parker E, Martin B, Meek J, Olson D, Farley M, Revis A, Holzbauer S, Bye M, Wilson L, Perlmutter R, Phipps E, Pierce R, Ocampo V, Kainer M, Smith M, McDonald L, Jernigan J, Guh A. 492. Long-Term Outcomes of Clostridium difficile Infection Among Medicare Beneficiaries. Open Forum Infectious Diseases 2018, 5: s182-s182. PMCID: PMC6253260, DOI: 10.1093/ofid/ofy210.501.Peer-Reviewed Original ResearchClostridium difficile infectionEmerging Infections ProgramDifficile infectionInclusion criteriaCommon healthcare-associated infectionsPrevention's Emerging Infections ProgramMultivariable logistic regression modelICD-9-CM codesOlder adultsDifficile stool testMedicaid Services beneficiariesNumber of hospitalizationsHealthcare-associated infectionsSkilled nursing facilitiesLong-term riskLogistic regression modelsSame catchment areaExcess morbidityHospitalization statusStool testPoor outcomeTerm outcomesAdjusted oddsCDI casesChronic conditions
2015
Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials
Baggs J, Yousey-Hindes K, Ashley ED, Meek J, Dumyati G, Cohen J, Wise ME, McDonald LC, Lessa FC. Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials. Vaccine 2015, 33: 6241-6249. PMID: 26450660, PMCID: PMC4702247, DOI: 10.1016/j.vaccine.2015.09.078.Peer-Reviewed Original ResearchConceptsEmerging Infections ProgramHigh-risk groupRisk groupsRisk scoreIndex hospitalizationHospital dischargeDerivation cohortVaccine trialsValidation cohortDifficile infectionCox proportional hazards modelRisk of CDIAcute care hospitalizationIdentification of patientsClostridium difficile infectionHospital discharge dataNumber of hospitalizationsLow-risk groupProportional hazards modelLarge academic centerAdmission diagnosisPrimary outcomeInpatient stayPatient populationPharmacy dataEmerging Infections Program—State Health Department Perspective - Volume 21, Number 9—September 2015 - Emerging Infectious Diseases journal - CDC
Hadler JL, Danila RN, Cieslak PR, Meek JI, Schaffner W, Smith KE, Cartter ML, Harrison LH, Vugia DJ, Lynfield R. Emerging Infections Program—State Health Department Perspective - Volume 21, Number 9—September 2015 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2015, 21: 1510-1515. PMID: 26289952, PMCID: PMC4550133, DOI: 10.3201/eid2109.150428.Peer-Reviewed Original ResearchConceptsEmerging Infections ProgramEIP sitesHealth departmentsDisease controlActive population-based surveillanceInfectious Diseases journal - CDCPopulation-based surveillanceState health departmentsPublic health challengeInfectious disease issuesPublic health programsInfections ProgramAcademic centersHealth programsHealth challengesPrevention fundsDepartment perspectiveDisease issuesDepartmentCenterPreventionTraining in Infectious Disease Epidemiology through the Emerging Infections Program Sites - Volume 21, Number 9—September 2015 - Emerging Infectious Diseases journal - CDC
Vugia DJ, Meek JI, Danila RN, Jones TF, Schaffner W, Baumbach J, Lathrop S, Farley MM, Tobin-D'Angelo M, Miller L, Harrison LH, Bennett NM, Cieslak PR, Cartter ML, Reingold AL. Training in Infectious Disease Epidemiology through the Emerging Infections Program Sites - Volume 21, Number 9—September 2015 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2015, 21: 1516-1519. PMID: 26291924, PMCID: PMC4550163, DOI: 10.3201/eid2109.150443.Peer-Reviewed Original ResearchConceptsEmerging Infections ProgramInfectious disease epidemiologyInfectious Diseases journal - CDCHealth care partnersLocal health departmentsLocal public healthDisease epidemiologyInfectious disease surveillancePeer-reviewed journalsEpidemiologic projectInfections ProgramUS CentersEIP sitesHealth departmentsCare partnersDisease controlDisease surveillancePublic healthEpidemiologyConference presentationsTrainee projectsProgram's inceptionExtent of trainingPresentationTraining opportunitiesPneumonia among adults hospitalized with laboratory-confirmed seasonal influenza virus infection—United States, 2005–2008
Garg S, Jain S, Dawood FS, Jhung M, Pérez A, D’Mello T, Reingold A, Gershman K, Meek J, Arnold KE, Farley MM, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett N, Thomas A, Schaffner W, Finelli L. Pneumonia among adults hospitalized with laboratory-confirmed seasonal influenza virus infection—United States, 2005–2008. BMC Infectious Diseases 2015, 15: 369. PMID: 26307108, PMCID: PMC4550040, DOI: 10.1186/s12879-015-1004-y.Peer-Reviewed Original ResearchConceptsIntensive care unit admissionSeasonal influenza virus infectionICD-9-CM codesCertain underlying conditionsEmerging Infections ProgramCare unit admissionLaboratory-confirmed influenzaInfluenza virus infectionCause of deathCXR infiltrateUnit admissionICU admissionOlder patientsMechanical ventilationMultivariable analysisUnderlying conditionInfections ProgramChest radiographsVirus infectionPneumoniaSummary diagnosisInfectious diseasesInfluenzaPatientsAdults
2011
Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study
Vandermeer M, Thomas A, Kamimoto L, Reingold A, Gershman K, Meek J, Farley M, Ryan P, Lynfield R, Baumbach J, Schaffner W, Bennett N, Zansky S. Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study. The Journal Of Infectious Diseases 2011, 205: 13-19. PMID: 22170954, DOI: 10.1093/infdis/jir695.Peer-Reviewed Original ResearchConceptsEmerging Infections ProgramLaboratory-confirmed influenzaInfluenza virus infectionVirus infectionPrevention's Emerging Infections ProgramMultivariable logistic regression modelInfluenza-related deathsChronic lung diseaseUse of statinsAdministration of statinsRisk of mortalityLogistic regression modelsProtective oddsHospitalized adultsInfluenza testsInfluenza vaccinationStatin useInfluenza seasonRenal diseaseAntiviral administrationImmunomodulatory effectsLung diseaseActive surveillanceInfections ProgramStatinsSeasonal and 2009 pandemic influenza A (H1N1) virus infection during pregnancy: a population-based study of hospitalized cases
Creanga A, Kamimoto L, Newsome K, D'Mello T, Jamieson D, Zotti M, Arnold K, Baumbach J, Bennett N, Farley M, Gershman K, Kirschke D, Lynfield R, Meek J, Morin C, Reingold A, Ryan P, Schaffner W, Thomas A, Zansky S, Finelli L, Honein M. Seasonal and 2009 pandemic influenza A (H1N1) virus infection during pregnancy: a population-based study of hospitalized cases. American Journal Of Obstetrics And Gynecology 2011, 204: s38-s45. PMID: 21507375, DOI: 10.1016/j.ajog.2011.02.037.Peer-Reviewed Original ResearchConceptsReproductive-aged womenPandemic influenza A (H1N1) virus infectionInfluenza A Virus InfectionA virus infectionPregnant womenPandemic influenzaVirus infectionExact testEmerging Infections ProgramPandemic influenza casesUnderlying medical conditionsPopulation-based studyPopulation-based dataFisher's exact testInfluenza vaccinationNonpregnant womenAntiviral treatmentSeasonal influenzaInfections ProgramInfluenza casesMedical conditionsPregnancyWomenInfluenzaSignificant proportion