2023
Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms
Chhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan W, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood L, Iacobuzio-Donahue C, Wolfgang C, Kunstman J, Salem R, Farrell J, Ahuja N. Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms. Clinical Epigenetics 2023, 15: 28. PMID: 36803844, PMCID: PMC9942382, DOI: 10.1186/s13148-023-01429-5.Peer-Reviewed Original ResearchConceptsPapillary mucinous neoplasmMalignant risk stratificationCACNA1G geneRisk stratificationMucinous neoplasmsBiomarker panelBackgroundIntraductal papillary mucinous neoplasmIntraductal papillary mucinous neoplasmEarly detectionPrevious case-control studyHigh-grade dysplasiaCase-control studyPancreatic cancer precursorsReceiver Operating Characteristic (ROC) curve analysisSignificant diagnostic challengeCross-sectional imagingCharacteristic curve analysisOperating Characteristic curve analysisG geneHigh diagnostic specificityPrior validation studiesSignificant procedural riskIPMN tissuesSurgical resectionAdvanced neoplasiaPrecision Medicine for Pancreas Cancer Treatment: A Multidisciplinary Challenge or Opportunity?
Farrell J, Robert M, Lacy J. Precision Medicine for Pancreas Cancer Treatment: A Multidisciplinary Challenge or Opportunity? Clinical Gastroenterology And Hepatology 2023, 21: 2740-2742. PMID: 36640803, DOI: 10.1016/j.cgh.2022.12.033.Peer-Reviewed Original Research
2018
Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors
Farrell J, Al-Haddad M, Jackson SA, Gonda T. Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors. Gastrointestinal Endoscopy 2018, 89: 832-841.e2. PMID: 30447214, DOI: 10.1016/j.gie.2018.10.049.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCyst FluidDNAEndoscopic Ultrasound-Guided Fine Needle AspirationFollow-Up StudiesGenes, Tumor SuppressorHumansKaplan-Meier EstimateLoss of HeterozygosityMutationPancreatic CystPancreatic NeoplasmsProportional Hazards ModelsProto-Oncogene Proteins p21(ras)Retrospective StudiesRisk AssessmentRisk FactorsSequence Analysis, DNASurvival AnalysisConceptsHigh-risk stigmataWorrisome featuresMalignancy riskPatient outcomesDNA abnormalitiesPredictive valueCyst fluid molecular analysisLong-term malignancy riskClinical risk factorsIncremental predictive valueCytologic malignancyClinical characteristicsFinal pathologyFree survivalSuch patientsPatient populationPancreatic cystsRisk factorsMalignant outcomeCyst fluidKras mutationsPatientsSurvival analysisAbnormalitiesTumor suppressor gene
2014
Chronic pancreatitis, a comprehensive review and update. Part I: Epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features
Muniraj T, Aslanian HR, Farrell J, Jamidar PA. Chronic pancreatitis, a comprehensive review and update. Part I: Epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features. Disease-a-Month 2014, 60: 530-550. PMID: 25510320, DOI: 10.1016/j.disamonth.2014.11.002.Peer-Reviewed Original Research
2007
Risk of Malignancy in Resected Cystic Tumors of the Pancreas ≤3 cm in Size: Is it Safe to Observe Asymptomatic Patients? A Multi-institutional Report
Lee C, Scheiman J, Anderson M, Hines O, Reber H, Farrell J, Kochman M, Foley P, Drebin J, Oh Y, Ginsberg G, Ahmad N, Merchant N, Isbell J, Parikh A, Stokes J, Bauer T, Adams R, Simeone D. Risk of Malignancy in Resected Cystic Tumors of the Pancreas ≤3 cm in Size: Is it Safe to Observe Asymptomatic Patients? A Multi-institutional Report. Journal Of Gastrointestinal Surgery 2007, 12: 234-242. PMID: 18040749, DOI: 10.1007/s11605-007-0381-y.Peer-Reviewed Original ResearchConceptsCystic pancreatic tumorsPancreatic resectionFemale patientsCystic neoplasmsRadiographic featuresPancreatic tumorsRecent international consensus guidelinesHigh-volume pancreatic centersPancreatic resection databaseGroup of patientsInternational consensus guidelinesPresence of malignancyPrevalence of malignancyMagnetic resonance imagingAsymptomatic patientsMale patientsPancreatic centersConsensus guidelinesPathological dataMalignant pathologyEndoscopic ultrasoundHigh incidencePatientsMalignancyGreater incidence
2006
Radiation Modifiers: Treatment Overview and Future Investigations
Thomas C, Ammar A, Farrell J, Elsaleh H. Radiation Modifiers: Treatment Overview and Future Investigations. Hematology/Oncology Clinics Of North America 2006, 20: 119-139. PMID: 16580560, DOI: 10.1016/j.hoc.2006.01.012.Peer-Reviewed Original Research
2003
Intraductal papillary mucinous tumors of the pancreas
Prasad S, Sahani D, Nasser S, Farrell J, Castillo C, Hahn P, Mueller P, Saini S. Intraductal papillary mucinous tumors of the pancreas. Abdominal Radiology 2003, 28: 0357-0365. PMID: 12719906, DOI: 10.1007/s00261-002-0037-z.Peer-Reviewed Original Research
2001
Detection and tumor staging of malignancy in cystic, intraductal, and solid tumors of the pancreas by EUS
Brandwein S, Farrell J, Centeno B, Brugge W. Detection and tumor staging of malignancy in cystic, intraductal, and solid tumors of the pancreas by EUS. Gastrointestinal Endoscopy 2001, 53: 722-727. PMID: 11375578, DOI: 10.1067/mge.2001.114783.Peer-Reviewed Original ResearchConceptsFine-needle aspirationIntraductal lesionsDirect fine needle aspirationEUS-guided fine-needle aspirationEvidence of malignancyResults of surgeryStaging of malignancyAccuracy of stagingAccuracy of EUSAbility of EUSSurgical explorationDuctal lesionsIntraductal tumorsPancreatic malignancyTumor stagingNeedle aspirationPancreatic massSolid lesionsEUS imagingMalignancySolid tumorsStaging malignanciesLesionsPancreasStagingDIVERTICULAR DISEASE IN THE ELDERLY
Farrell R, Farrell J, Morrin M. DIVERTICULAR DISEASE IN THE ELDERLY. Gastroenterology Clinics Of North America 2001, 30: 475-496. PMID: 11432301, DOI: 10.1016/s0889-8553(05)70191-6.Peer-Reviewed Original Research
2000
GASTROINTESTINAL BLEEDING IN OLDER PEOPLE
Farrell J, Friedman L. GASTROINTESTINAL BLEEDING IN OLDER PEOPLE. Gastroenterology Clinics Of North America 2000, 29: 1-36. PMID: 10752016, DOI: 10.1016/s0889-8553(05)70106-0.Peer-Reviewed Original ResearchConceptsGastrointestinal bleedingOlder peopleGreater medication useLower gastrointestinal bleedingAtypical clinical presentationCommon clinical challengeRates of comorbidityHemodynamic resuscitationSurgical therapyMedication useClinical presentationCommon causeClinical challengeBleedingAnticoagulationImportant management issuesComorbiditiesResuscitationTherapy