2019
Posttraumatic Stress Disorder and Risk for Stroke in Young and Middle-Aged Adults
Rosman L, Sico JJ, Lampert R, Gaffey AE, Ramsey CM, Dziura J, Chui PW, Cavanagh CE, Brandt C, Haskell S, Burg MM. Posttraumatic Stress Disorder and Risk for Stroke in Young and Middle-Aged Adults. Stroke 2019, 50: 2996-3003. PMID: 31619151, DOI: 10.1161/strokeaha.119.026854.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIncident transient ischemic attackPosttraumatic stress disorderEffects of PTSDIschemic strokeIncident strokeHealthcare utilizationIncidence of TIAStress disorderYoung adultsMiddle-aged veteransStroke risk factorsMultivariate Cox modelIschemic stroke riskAge-specific prevention strategiesVeterans Health AdministrationMiddle-aged adultsIschemic attackStroke riskPsychological factorsUnadjusted analysesRisk factorsEffect modificationCox modelPsychiatric disorders
2018
Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis
Perdigoto AL, Preston-Hurlburt P, Clark P, Long SA, Linsley PS, Harris KM, Gitelman SE, Greenbaum CJ, Gottlieb PA, Hagopian W, Woodwyk A, Dziura J, Herold KC. Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis. Diabetologia 2018, 62: 655-664. PMID: 30569273, PMCID: PMC6402971, DOI: 10.1007/s00125-018-4786-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntibodies, Monoclonal, HumanizedArea Under CurveAutoimmunityCD3 ComplexCD8-Positive T-LymphocytesChildC-PeptideCytokinesDiabetes Mellitus, Type 1FemaleFollow-Up StudiesHumansHypoglycemic AgentsInsulinIslets of LangerhansMaleRandomized Controlled Trials as TopicRemission InductionTreatment OutcomeYoung AdultConceptsC-peptide responseType 1 diabetesMixed meal tolerance testDetectable C-peptideC-peptideInsulin useTolerance testT cellsControl groupNew-onset type 1 diabetesPeripheral blood mononuclear cellsConclusions/interpretationThese findingsAnti-CD3 monoclonal antibodyDaily insulin useBlood mononuclear cellsDiagnosis of diabetesSuccessful immune therapiesOriginal control groupCell death proteinAnergic CD8ResultsFifty-sixImmune therapyInterpretationThese findingsMononuclear cellsCytokine release
2017
Depression is associated with recurrent chest pain with or without coronary artery disease: A prospective cohort study in the emergency department
Kim Y, Soffler M, Paradise S, Jelani QU, Dziura J, Sinha R, Safdar B. Depression is associated with recurrent chest pain with or without coronary artery disease: A prospective cohort study in the emergency department. American Heart Journal 2017, 191: 47-54. PMID: 28888269, DOI: 10.1016/j.ahj.2017.06.003.Peer-Reviewed Original ResearchConceptsRecurrent chest painCoronary artery diseaseAcute chest painChest painProspective cohort studyChest pain centerClinical Anxiety ScaleEmergency departmentPerceived Stress ScalePain centerCohort studyArtery diseaseNonobstructive coronary artery diseaseObstructive coronary artery diseaseChest pain recurrenceED chest painCardiac risk factorsCardiac stress testingPatient Health QuestionnaireSignificant independent predictorsStress testingMultivariable regression modelsPain recurrenceIndependent predictorsPrimary outcomeRisk for Incident Hypertension Associated With Posttraumatic Stress Disorder in Military Veterans and the Effect of Posttraumatic Stress Disorder Treatment
Burg MM, Brandt C, Buta E, Schwartz J, Bathulapalli H, Dziura J, Edmondson DE, Haskell S. Risk for Incident Hypertension Associated With Posttraumatic Stress Disorder in Military Veterans and the Effect of Posttraumatic Stress Disorder Treatment. Psychosomatic Medicine 2017, 79: 181-188. PMID: 27490852, PMCID: PMC5285494, DOI: 10.1097/psy.0000000000000376.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleFollow-Up StudiesHumansHypertensionMaleRiskStress Disorders, Post-TraumaticUnited StatesVeteransYoung AdultConceptsPosttraumatic stress disorderPosttraumatic stress disorder (PTSD) treatmentHypertension riskHazard ratioDisorder treatmentSelective serotonin reuptake inhibitor medicationsSerotonin reuptake inhibitor medicationsStress disorderIncident hypertension riskClinic blood pressureCardiovascular mortality riskInteraction of PTSDReuptake inhibitor medicationsLong-term health impactsStress disorder diagnosisPosttraumatic stress disorder (PTSD) diagnosisAntihypertensive medicationsHypertension AssociatedIncident hypertensionHypertensive rangeBlood pressureInhibitor medicationMedical visitsCardiovascular diseaseMortality risk
2016
Laminectomy plus Fusion versus Laminectomy Alone for Lumbar Spondylolisthesis
Ghogawala Z, Dziura J, Butler WE, Dai F, Terrin N, Magge SN, Coumans JV, Harrington JF, Amin-Hanjani S, Schwartz JS, Sonntag VK, Barker FG, Benzel EC. Laminectomy plus Fusion versus Laminectomy Alone for Lumbar Spondylolisthesis. New England Journal Of Medicine 2016, 374: 1424-1434. PMID: 27074067, DOI: 10.1056/nejmoa1508788.Peer-Reviewed Original ResearchConceptsPhysical component summary scoreDecompression-alone groupSF-36 physical component summary scoreFusion groupSummary scoresDecompressive laminectomySpinal stenosisGrade IOutcome measuresSpinal fusionOswestry Disability Index scoresSymptomatic lumbar spinal stenosisPhysical health-related qualityDegenerative grade IStable degenerative spondylolisthesisLonger hospital stayMore blood lossOswestry Disability IndexDisability Index scoresSecondary outcome measuresHealth-related qualityMedical Outcomes StudyPosterolateral instrumented fusionPrimary outcome measureLumbar spinal stenosis
2015
Chest pain syndromes are associated with high rates of recidivism and costs in young United States Veterans
Safdar B, Dziura J, Bathulapalli H, Leslie DL, Skanderson M, Brandt C, Haskell SG. Chest pain syndromes are associated with high rates of recidivism and costs in young United States Veterans. BMC Primary Care 2015, 16: 88. PMID: 26202799, PMCID: PMC4511555, DOI: 10.1186/s12875-015-0287-9.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseUnexplained chest painChest painUCP patientsCAD patientsArtery diseaseRisk factorsReturn visitsSpecific ICD-9 codesVeterans AffairsChest pain syndromeRecurrent chest painReference groupRetrospective cohort studyEvidence-based guidelinesICD-9 codesUnited States veteransDirect total costCAD cohortCause deathCardiac painPain syndromeCohort studyCox regressionEmergency department
2012
Left Ventricular Ejection Fraction and Left Ventricular End‐Diastolic Volume in Patients With Diastolic Dysfunction
Jovin IS, Ebisu K, Liu Y, Finta LA, Oprea AD, Brandt CA, Dziura J, Wackers FJ. Left Ventricular Ejection Fraction and Left Ventricular End‐Diastolic Volume in Patients With Diastolic Dysfunction. Congestive Heart Failure 2012, 19: 130-134. PMID: 23241105, DOI: 10.1111/chf.12013.Peer-Reviewed Original ResearchConceptsLVEF of patientsLeft ventricular ejection fractionLower peak filling ratePeak filling rateEnd-diastolic volumeNormal peak filling ratesEquilibrium radionuclide angiocardiographyVentricular ejection fractionDiastolic dysfunctionAsymptomatic patientsEjection fractionLow left ventricular ejection fractionNormal left ventricular ejection fractionVentricular end-diastolic volumeMild systolic dysfunctionNormal systolic functionEDV indexSystolic dysfunctionSystolic functionRadionuclide angiocardiographyPatientsDysfunctionRepeat scansFilling rateAngiocardiographyDevelopment of a scale to measure practitioner adherence to a brief intervention in the emergency department
Pantalon MV, Martino S, Dziura J, Li FY, Owens PH, Fiellin DA, O'Connor PG, D'Onofrio G. Development of a scale to measure practitioner adherence to a brief intervention in the emergency department. Journal Of Substance Use And Addiction Treatment 2012, 43: 382-388. PMID: 23021098, PMCID: PMC3661016, DOI: 10.1016/j.jsat.2012.08.011.Peer-Reviewed Original ResearchConceptsBrief Negotiation InterviewBrief interventionTwo-factor structureExcellent internal consistencyGood construct validityDiscriminant validityPredictive validityEmergency departmentExcellent inter-rater reliabilityPsychometric propertiesEight-itemConstruct validityHazardous drinkingInternal consistencyEmergency department patientsPractitioner adherenceInter-rater reliabilityDepartment patientsAdherence ScaleClinical practiceValidityInterventionSkillsAdherenceScaleComparison of the Effect on Long-Term Outcomes in Patients With Thoracic Aortic Aneurysms of Taking Versus Not Taking a Statin Drug
Jovin IS, Duggal M, Ebisu K, Paek H, Oprea AD, Tranquilli M, Rizzo J, Memet R, Feldman M, Dziura J, Brandt CA, Elefteriades JA. Comparison of the Effect on Long-Term Outcomes in Patients With Thoracic Aortic Aneurysms of Taking Versus Not Taking a Statin Drug. The American Journal Of Cardiology 2012, 109: 1050-1054. PMID: 22221941, DOI: 10.1016/j.amjcard.2011.11.038.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmLong-term outcomesComposite end pointAortic aneurysmAneurysm repairEnd pointImproved long-term outcomesOutcomes of patientsCohort of patientsKaplan-Meier analysisMedian followStatin intakeStatin therapyMedical therapyStatinsFirst presentationPatientsSurvival rateAneurysmsStatin drugsOutcomesTherapyIntakeRepairCohort
2011
Long-term Results of an Obesity Program in an Ethnically Diverse Pediatric Population
Savoye M, Nowicka P, Shaw M, Yu S, Dziura J, Chavent G, O'Malley G, Serrecchia JB, Tamborlane WV, Caprio S. Long-term Results of an Obesity Program in an Ethnically Diverse Pediatric Population. Pediatrics 2011, 127: 402-410. PMID: 21300674, PMCID: PMC3065145, DOI: 10.1542/peds.2010-0697.Peer-Reviewed Original ResearchConceptsControl groupLow-density lipoprotein cholesterolTotal body fat massIntensive lifestyle programIntensive lifestyle interventionHomeostasis model assessmentActive intervention phaseWeight management programBody fat massLong-term resultsBMI z-scorePercent body fatDiverse pediatric populationFamily-based programsLifestyle interventionLipoprotein cholesterolTotal cholesterolObese childrenObese populationPediatric populationInsulin resistanceObesity programLifestyle programFat massIntervention group
2009
Relationship of Serum S100B Levels and Intracranial Injury in Children With Closed Head Trauma
Bechtel K, Frasure S, Marshall C, Dziura J, Simpson C. Relationship of Serum S100B Levels and Intracranial Injury in Children With Closed Head Trauma. Pediatrics 2009, 124: e697-e704. PMID: 19786430, DOI: 10.1542/peds.2008-1493.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsBiomarkersBrain InjuriesCase-Control StudiesChildChild, PreschoolEmergency Service, HospitalFemaleFollow-Up StudiesFractures, BoneGlasgow Coma ScaleHead Injuries, ClosedHumansInjury Severity ScoreMaleMultiple TraumaNerve Growth FactorsPredictive Value of TestsProbabilityRetrospective StudiesRisk AssessmentS100 Calcium Binding Protein beta SubunitS100 ProteinsSex FactorsSurvival AnalysisTomography, X-Ray ComputedConceptsLong bone fracturesTime of venipunctureSerum S100B measurementClosed head traumaIntracranial injurySerum S100B levelsS100B levelsS100B measurementHead traumaUrban pediatric emergency departmentMean S100B levelsLevels of S100BPediatric emergency departmentYears of ageReferral hospitalSerum levelsEmergency departmentCranial CTSkeletal injuriesAnalysis of covarianceBone fracturesInjuryNonwhite childrenVenipunctureChildrenEffects of coping skills training in school‐age children with type 1 diabetes
Grey M, Whittemore R, Jaser S, Ambrosino J, Lindemann E, Liberti L, Northrup V, Dziura J. Effects of coping skills training in school‐age children with type 1 diabetes. Research In Nursing & Health 2009, 32: 405-418. PMID: 19488997, PMCID: PMC2720049, DOI: 10.1002/nur.20336.Peer-Reviewed Original Research
2008
Socioeconomic predictors of weight loss after laparoscopic Roux-Y gastric bypass
Akkary E, Nerlinger A, Yu S, Dziura J, Duffy AJ, Bell RL. Socioeconomic predictors of weight loss after laparoscopic Roux-Y gastric bypass. Surgical Endoscopy 2008, 23: 1246-1251. PMID: 18813989, DOI: 10.1007/s00464-008-0138-z.Peer-Reviewed Original ResearchConceptsBody mass indexInitial body mass indexPostoperative weight lossWeight lossLaparoscopic RouxBMI decreaseSocioeconomic statusInitial mean body mass indexMedian household incomeMean body mass indexPrivate insuranceAppropriate patient selectionPrivate insurance groupPostoperative behavioral changesInsurance carriersProspective databaseGastric bypassPatient demographicsSingle surgeonMass indexPatient selectionGroup APatientsLRYGBHousehold incomeThe paradox of the pouch: prompt emptying predicts improved weight loss after laparoscopic Roux-Y gastric bypass
Akkary E, Sidani S, Boonsiri J, Yu S, Dziura J, Duffy AJ, Bell RL. The paradox of the pouch: prompt emptying predicts improved weight loss after laparoscopic Roux-Y gastric bypass. Surgical Endoscopy 2008, 23: 790. PMID: 18806946, DOI: 10.1007/s00464-008-0069-8.Peer-Reviewed Original ResearchConceptsWeight lossGastric bypassLaparoscopic RouxOperative timeGastric pouchSlow emptyingAnalysis of covarianceBody mass index lossLinear stapler techniqueUpper gastrointestinal evaluationGroup B patientsPostoperative day 1Postoperative weight lossInfluences weight lossLength of stayMore weight lossAnastomotic edemaUGI studiesProspective databaseRate of contrastB patientsGastrointestinal evaluationPatient demographicsSingle surgeonNormal gastricSleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure
Nakra N, Bhargava S, Dzuira J, Caprio S, Bazzy-Asaad A. Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure. Pediatrics 2008, 122: e634-e642. PMID: 18762497, PMCID: PMC5117807, DOI: 10.1542/peds.2008-0154.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep-disordered breathingSympathetic nervous system activityPositive airway pressureNervous system activityWhole-body insulin sensitivityMetabolic syndromeAirway pressureLeptin levelsInsulin sensitivitySystem activityExact testContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentC-reactive protein levelsOral glucose tolerance testGlucose tolerance testRole of leptinBMI z-scoreFisher's exact testOvernight polysomnographyBreathing groupMetabolic derangementsInsulin resistanceSleep QuestionnaireEducating Adolescents About Acne Vulgaris: A Comparison of Written Handouts With Audiovisual Computerized Presentations
Koch PE, Ryder HF, Dziura J, Njike V, Antaya RJ. Educating Adolescents About Acne Vulgaris: A Comparison of Written Handouts With Audiovisual Computerized Presentations. JAMA Dermatology 2008, 144: 208-214. PMID: 18283177, DOI: 10.1001/archdermatol.2007.35.Peer-Reviewed Original ResearchConceptsAcne vulgarisAdolescent patientsIntervention groupWritten handoutPilot studyGeneral pediatric clinicPrivate dermatology officeBaseline knowledgeEnrollment questionnairePediatric clinicBaseline questionnaireDermatology officePatientsHandout groupBaselineIdentical questionnairesSignificant differencesLong-term knowledge gainPostinterventionPresentationQuestionnaireMonthsInterventionRespective studiesSignificant improvement
2006
Is It Safe to Delay Appendectomy in Adults With Acute Appendicitis?
Ditillo MF, Dziura JD, Rabinovici R. Is It Safe to Delay Appendectomy in Adults With Acute Appendicitis? Annals Of Surgery 2006, 244: 656-660. PMID: 17060754, PMCID: PMC1856602, DOI: 10.1097/01.sla.0000231726.53487.dd.Peer-Reviewed Original ResearchConceptsAcute appendicitisOnset of symptomsAdvanced pathologyAdult patientsPrompt appendectomyPostoperative complicationsEmergency roomAntibiotic treatmentProgressive pathologyRight lower quadrantRisk of progressionLength of stayStandard of careGangrenous acute appendicitisHigher pathology gradeTotal intervalDegree of pathologyElective mannerHospital intervalHospital delayHospital stayAntibiotic therapyPediatric patientsRetrospective reviewPathologic findings
2004
Persistence of Benefits of Continuous Subcutaneous Insulin Infusion in Very Young Children With Type 1 Diabetes: A Follow-up Report
Weinzimer SA, Ahern JH, Doyle EA, Vincent MR, Dziura J, Steffen AT, Tamborlane WV. Persistence of Benefits of Continuous Subcutaneous Insulin Infusion in Very Young Children With Type 1 Diabetes: A Follow-up Report. Pediatrics 2004, 114: 1601-1605. PMID: 15574621, DOI: 10.1542/peds.2004-0092.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionType 1 diabetesMultiple daily injectionsSubcutaneous insulin infusionSevere hypoglycemiaDaily injectionsInsulin infusionRate of SHMonths of CSIIYoung childrenEpisodes of DKAOlder pediatric patientsVery Young ChildrenPersistence of benefitHypoglycemia frequencyYounger patientsGlycemic controlPediatric patientsPump treatmentClinic databaseSafety dataEmergency treatmentAge groupsType 1DiabetesObesity and the Metabolic Syndrome in Children and Adolescents
Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. Obesity and the Metabolic Syndrome in Children and Adolescents. New England Journal Of Medicine 2004, 350: 2362-2374. PMID: 15175438, DOI: 10.1056/nejmoa031049.Peer-Reviewed Original ResearchMeSH KeywordsAdiponectinAdolescentAdultChildChild, PreschoolC-Reactive ProteinFemaleFollow-Up StudiesGlucose Tolerance TestHumansInsulin ResistanceIntercellular Signaling Peptides and ProteinsInterleukin-6Logistic ModelsMaleMetabolic SyndromeObesityPrevalenceProteinsRisk FactorsSeverity of Illness IndexConceptsDegree of obesityC-reactive proteinMetabolic syndromeBody mass indexAdiponectin levelsInsulin resistanceBlood pressureStandard glucose tolerance testC-reactive protein levelsHigh-density lipoprotein cholesterolZ-scoreAdverse cardiovascular outcomesSeverity of obesityGlucose tolerance testLevels of triglyceridesCardiovascular outcomesLipoprotein cholesterolObese subjectsObese childrenUnit of increaseMultiracial cohortNonobese childrenPlasma lipidsChildhood obesityObesity