2011
Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia
Szepietowska B, Zhu W, Chan O, Horblitt A, Dziura J, Sherwin RS. Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia. Diabetes 2011, 60: 3154-3158. PMID: 22013013, PMCID: PMC3219955, DOI: 10.2337/db11-0432.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-2 Receptor AgonistsAdrenergic beta-AntagonistsAnimalsBlood GlucoseEpinephrineEthanolaminesFormoterol FumarateGlucagonGlucose Clamp TechniqueHypoglycemiaImidazolesInsulinMaleNorepinephrinePropanolaminesRatsRats, Sprague-DawleyReceptors, Adrenergic, betaVentromedial Hypothalamic NucleusConceptsCounterregulatory responsesVentromedial hypothalamusGlucose counterregulationAwake male Sprague-Dawley ratsB2AR agonistMale Sprague-Dawley ratsCounterregulatory hormone releaseDefective glucose counterregulationExogenous glucose requirementsHyperinsulinemic-hypoglycemic clamp studySprague-Dawley ratsLocal catecholamine releaseArtificial extracellular fluidΒ-Adrenergic ReceptorsEpinephrine responseGlucagon responseDiabetic patientsEpinephrine releaseSimilar insulinCatecholamine releaseHormone releaseGuide cannulaeClamp studiesTherapeutic benefitHypoglycemia
2008
Effect of Acute and Recurrent Hypoglycemia on Changes in Brain Glycogen Concentration
Herzog RI, Chan O, Yu S, Dziura J, McNay EC, Sherwin RS. Effect of Acute and Recurrent Hypoglycemia on Changes in Brain Glycogen Concentration. Endocrinology 2008, 149: 1499-1504. PMID: 18187548, PMCID: PMC2276713, DOI: 10.1210/en.2007-1252.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsBrainEpinephrineGlycogenHypoglycemiaMaleRatsRats, Sprague-DawleyRecurrenceConceptsHypoglycemia-associated autonomic failureRecurrent hypoglycemiaAcute hypoglycemiaAutonomic failureBrain glycogenGlycogen levelsBrain glucoseGlucose levelsRH groupInsulin-induced acute hypoglycemiaSimilar blood glucose levelsIntensive insulin treatmentHyperinsulinemic-hypoglycemic clamp studyBrain glycogen concentrationHypoglycemic clamp studiesBlood glucose levelsBrain glucose levelsCounterregulatory failureDiabetic patientsGlycogen supercompensationRecurrent episodesSingle boutInsulin treatmentClamp studiesAnimal models
2002
Brain glucose levels are elevated in chronically hyperglycemic diabetic rats: No evidence for protective adaptation by the blood brain barrier
Jacob RJ, Fan X, Evans ML, Dziura J, Sherwin RS. Brain glucose levels are elevated in chronically hyperglycemic diabetic rats: No evidence for protective adaptation by the blood brain barrier. Metabolism 2002, 51: 1522-1524. PMID: 12489061, DOI: 10.1053/meta.2002.36347.Peer-Reviewed Original ResearchConceptsDiabetic ratsBB/Wor diabetic ratsLong-term adverse effectsHyperglycemic diabetic ratsProtective adaptationBlood-brain barrier transferPlasma glucose ratioBlood-brain barrierBeta-hydroxybutyrate levelsBrain glucose levelsECF glucoseAcute hyperglycemiaChronic hyperglycemiaBlood glucoseBrain barrierHyperglycemic groupPeripheral tissuesGlucose levelsBeta-OHBInferior colliculusECF levelsProlonged elevationHyperglycemiaFluid glucoseBrain tissue