2022
Gender Differences in Guideline-Directed Medical Therapy for Cardiovascular Disease Among Young Veterans
Dhruva SS, Dziura J, Bathulapalli H, Rosman L, Gaffey AE, Davis MB, Brandt CA, Haskell SG. Gender Differences in Guideline-Directed Medical Therapy for Cardiovascular Disease Among Young Veterans. Journal Of General Internal Medicine 2022, 37: 806-815. PMID: 36042086, PMCID: PMC9481764, DOI: 10.1007/s11606-022-07595-1.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyIncident coronary artery diseaseCoronary artery diseaseHeart failureMedical therapyCardiovascular diseaseWomen veteransDiagnosis of HFAldosterone system inhibitorsIncident heart failureAdverse cardiovascular outcomesClinical practice guidelinesRisk of mortalityLevel of evidenceYounger women veteransHF medicationsMultiple pharmacotherapiesAntiplatelet therapyCardiovascular outcomesYounger average ageArtery diseaseCVD careGuideline recommendationsSystem inhibitorsAdverse outcomesAssociation of renalase with clinical outcomes in hospitalized patients with COVID-19
Safdar B, Wang M, Guo X, Cha C, Chun HJ, Deng Y, Dziura J, El-Khoury JM, Gorelick F, Ko AI, Lee AI, Safirstein R, Simonov M, Zhou B, Desir GV. Association of renalase with clinical outcomes in hospitalized patients with COVID-19. PLOS ONE 2022, 17: e0264178. PMID: 35259186, PMCID: PMC8903289, DOI: 10.1371/journal.pone.0264178.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsRenalase levelsIntensive care unit admissionHospitalized COVID-19 patientsMean age 64 yearsCOVID-19Cox proportional hazards modelCare unit admissionPrimary composite outcomeRetrospective cohort studyUse of vasopressorsSevere COVID-19IL-6 levelsAge 64 yearsRisk of deathCOVID-19 subjectsInitial disease severityProportional hazards modelCOVID-19 diseasePlasma renalaseUnit admissionICU admissionCohort studyComposite outcomeCytokine levels
2021
Variations in Quality of Care by Sex and Social Determinants of Health Among Younger Adults With Acute Myocardial Infarction in the US and Canada
Raparelli V, Pilote L, Dang B, Behlouli H, Dziura JD, Bueno H, D’Onofrio G, Krumholz HM, Dreyer RP. Variations in Quality of Care by Sex and Social Determinants of Health Among Younger Adults With Acute Myocardial Infarction in the US and Canada. JAMA Network Open 2021, 4: e2128182. PMID: 34668947, PMCID: PMC8529414, DOI: 10.1001/jamanetworkopen.2021.28182.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionQuality of careHealth care systemYoung adultsFemale sexMyocardial infarctionCare systemHospital careSocial determinantsRetrospective cohort analysisLow qualityAdverse SDOHLowest tertileReadmission ratesMore patientsPostacute careAMI careOutpatient careCare scoresHigh prevalenceCohort analysisLarge cohortMAIN OUTCOMESDOHHospital
2017
Evaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department
Swenson KE, Dziura JD, Aydin A, Reynolds J, Wira CR. Evaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department. Internal And Emergency Medicine 2017, 13: 257-268. PMID: 28132131, DOI: 10.1007/s11739-017-1607-y.Peer-Reviewed Original ResearchConceptsInitial serum lactate levelSerum lactate levelsEmergency departmentLactate elevationVasoplegic shockLactate levelsCryptic shockVasopressor useInfected patientsShock mortalityHigh-risk ED patientsGroup mortality rateInitial serum lactateVasopressor-dependent patientsIdentifiable risk factorsSepsis-3 definitionRisk-stratify patientsHigh-risk subgroupsInitial lactate levelProximal phaseVasopressor dependenceVasopressor requirementHospital outcomesED patientsSerum lactate
2015
The influence of clopidogrel on ischemia diagnosed by myocardial perfusion stress testing
Jovin IS, Ebisu KA, Oprea AD, Brandt CA, Natale D, Finta LA, Dziura J, Wackers FJ. The influence of clopidogrel on ischemia diagnosed by myocardial perfusion stress testing. Journal Of Nuclear Cardiology 2015, 23: 773-779. PMID: 26338428, DOI: 10.1007/s12350-015-0268-3.Peer-Reviewed Original ResearchConceptsReversible perfusion defectsOdds ratioPerfusion defectsMyocardial perfusion stress testMyocardial perfusion stress testingStress testStress myocardial perfusion scansMyocardial single photon emissionAdenosine stress testInfluence of clopidogrelLikelihood of ischemiaMyocardial perfusion testingUse of clopidogrelCoronary vascular toneExercise stress testMyocardial perfusion scanMyocardial perfusion imagingSingle photon emissionAdenosine receptor antagonistDiagnosis of ischemiaPerfusion scanPerfusion testingVascular toneReceptor antagonistTomography scanChest pain syndromes are associated with high rates of recidivism and costs in young United States Veterans
Safdar B, Dziura J, Bathulapalli H, Leslie DL, Skanderson M, Brandt C, Haskell SG. Chest pain syndromes are associated with high rates of recidivism and costs in young United States Veterans. BMC Primary Care 2015, 16: 88. PMID: 26202799, PMCID: PMC4511555, DOI: 10.1186/s12875-015-0287-9.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseUnexplained chest painChest painUCP patientsCAD patientsArtery diseaseRisk factorsReturn visitsSpecific ICD-9 codesVeterans AffairsChest pain syndromeRecurrent chest painReference groupRetrospective cohort studyEvidence-based guidelinesICD-9 codesUnited States veteransDirect total costCAD cohortCause deathCardiac painPain syndromeCohort studyCox regressionEmergency department
2014
Epidemiological and Clinical Characteristics of Imported Malaria in the United Arab Emirates
Nilles EJ, Alosert, Mohtasham MA, Saif M, Sulaiman L, Seliem RM, Kotlyar S, Dziura JD, Al‐Najjar F. Epidemiological and Clinical Characteristics of Imported Malaria in the United Arab Emirates. Journal Of Travel Medicine 2014, 21: 201-206. PMID: 24628958, DOI: 10.1111/jtm.12110.Peer-Reviewed Original ResearchConceptsMalaria casesIntensive care supportSmear positive malariaP. vivax/P.Cases of malariaMalaria-endemic regionsElectronic medical record systemWorld Health OrganizationEndemic malaria transmissionLarge public hospitalImported MalariaRetrospective laboratoryChart reviewClinical characteristicsLaboratory characteristicsMedical record systemFalciparum infectionVivax infectionVivax casesLaboratory recordsSevere diseaseHealth facilitiesP. vivaxPlasmodium vivaxImportant causeImpact of Early Extubation and Reintubation on the Incidence of Bronchopulmonary Dysplasia in Neonates
Berger J, Mehta P, Bucholz E, Dziura J, Bhandari V. Impact of Early Extubation and Reintubation on the Incidence of Bronchopulmonary Dysplasia in Neonates. American Journal Of Perinatology 2014, 31: 1063-1072. PMID: 24683068, DOI: 10.1055/s-0034-1371702.Peer-Reviewed Original ResearchMeSH KeywordsAirway ExtubationApgar ScoreBirth WeightBronchopulmonary DysplasiaDisease-Free SurvivalDuctus Arteriosus, PatentFemaleGestational AgeHumansIncidenceInfant, NewbornIntracranial HemorrhagesIntubation, IntratrachealKaplan-Meier EstimateMaleProportional Hazards ModelsRespiratory Distress Syndrome, NewbornRetinopathy of PrematurityRetreatmentRetrospective StudiesTime FactorsElevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients
Safdar B, Bezek SK, Sinusas AJ, Russell RR, Klein MR, Dziura JD, D’onofrio G. Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2014, 13: 14-19. PMID: 24526146, DOI: 10.1097/hpc.0000000000000001.Peer-Reviewed Original ResearchConceptsAdverse cardiac eventsCPU patientsNormal troponinAdverse eventsCardiac eventsMultiple logistic regression modelComposite adverse eventsElevated creatinine kinaseObservation unit patientsSerial troponin testingStandardized chart reviewRetrospective cohort studyAcute coronary syndromeNational Death RegistryCoronary artery diseaseLogistic regression modelsPositive troponinPrior CADRenal insufficientCoronary syndromeHemodynamic instabilityChart reviewCohort studyDeath RegistryIschemic electrocardiogram
2013
Point-of-Care Focused Cardiac Ultrasound for Prediction of Pulmonary Embolism Adverse Outcomes
Taylor RA, Davis J, Liu R, Gupta V, Dziura J, Moore CL. Point-of-Care Focused Cardiac Ultrasound for Prediction of Pulmonary Embolism Adverse Outcomes. Journal Of Emergency Medicine 2013, 45: 392-399. PMID: 23827166, DOI: 10.1016/j.jemermed.2013.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overEchocardiographyEmergency Service, HospitalFemaleHemorrhageHospital MortalityHumansMaleMiddle AgedPoint-of-Care SystemsPredictive Value of TestsPrognosisPulmonary EmbolismRecurrenceRespiratory InsufficiencyRetrospective StudiesRisk FactorsShockVenous ThromboembolismVentricular Dysfunction, RightConceptsRight ventricular strainHospital adverse outcomesRetrospective chart reviewPulmonary embolismAdverse outcomesEmergency departmentChart reviewCardiac ultrasoundHighest positive likelihood ratioRecurrent venous thromboembolismLow negative likelihood ratioSignificant predictorsEmergency care practitionersFocused cardiac ultrasoundFOCUS examinationPositive likelihood ratioNegative likelihood ratioMajor bleedingLikelihood ratioRespiratory failureVenous thromboembolismTransthoracic echocardiographyHospital admissionIndependent predictorsVentricular strain
2012
Left Ventricular Ejection Fraction and Left Ventricular End‐Diastolic Volume in Patients With Diastolic Dysfunction
Jovin IS, Ebisu K, Liu Y, Finta LA, Oprea AD, Brandt CA, Dziura J, Wackers FJ. Left Ventricular Ejection Fraction and Left Ventricular End‐Diastolic Volume in Patients With Diastolic Dysfunction. Congestive Heart Failure 2012, 19: 130-134. PMID: 23241105, DOI: 10.1111/chf.12013.Peer-Reviewed Original ResearchConceptsLVEF of patientsLeft ventricular ejection fractionLower peak filling ratePeak filling rateEnd-diastolic volumeNormal peak filling ratesEquilibrium radionuclide angiocardiographyVentricular ejection fractionDiastolic dysfunctionAsymptomatic patientsEjection fractionLow left ventricular ejection fractionNormal left ventricular ejection fractionVentricular end-diastolic volumeMild systolic dysfunctionNormal systolic functionEDV indexSystolic dysfunctionSystolic functionRadionuclide angiocardiographyPatientsDysfunctionRepeat scansFilling rateAngiocardiographyCT Overuse for Mild Traumatic Brain Injury
Melnick ER, Szlezak CM, Bentley SK, Dziura JD, Kotlyar S, Post LA. CT Overuse for Mild Traumatic Brain Injury. The Joint Commission Journal On Quality And Patient Safety 2012, 38: 483-489. PMID: 23173394, DOI: 10.1016/s1553-7250(12)38064-1.Peer-Reviewed Original ResearchConceptsMild traumatic brain injuryCanadian CT Head RuleNew Orleans CriteriaTraumatic brain injuryProportion of casesComputed tomographyEmergency departmentBrain injuryCT useEmergency Physicians Clinical PolicyLevel I emergency departmentImportant brain injuryClinical Excellence (NICE) guidelinesMinor head injuryProspective observational studyCurrent guideline recommendationsHead CT findingsEvidence-based guidelinesHealth care costsRadiation-induced cancerCT overuseAdult patientsExcellence guidelinesCT findingsGuideline recommendationsPoint‐of‐care Focused Cardiac Ultrasound for the Assessment of Thoracic Aortic Dimensions, Dilation, and Aneurysmal Disease
Taylor RA, Oliva I, Van Tonder R, Elefteriades J, Dziura J, Moore CL. Point‐of‐care Focused Cardiac Ultrasound for the Assessment of Thoracic Aortic Dimensions, Dilation, and Aneurysmal Disease. Academic Emergency Medicine 2012, 19: 244-247. PMID: 22288871, DOI: 10.1111/j.1553-2712.2011.01279.x.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic dilationThoracic aortic dimensionsCT angiographyTransthoracic echocardiographyAortic dissectionBland-Altman plotsAortic dimensionsEmergency departmentAortic aneurysmEmergency physiciansCardiac ultrasoundPilot studyNinety-two patientsThoracic aorta pathologyFurther prospective studiesThoracic aortic diameterThoracic aortic pathologyRetrospective pilot studySinus of ValsalvaAcademic emergency departmentCTA measurementsFocused cardiac ultrasoundRetrospective pilot analysisReference standard
2011
Endoscopic Ultrasound Identifies Synchronous Pancreas Cystic Lesions Not Seen on Initial Cross-Sectional Imaging
Adimoolam V, Sanchez MJ, Siddiqui UD, Yu S, Dzuira JD, Padda MS, Aslanian HR. Endoscopic Ultrasound Identifies Synchronous Pancreas Cystic Lesions Not Seen on Initial Cross-Sectional Imaging. Pancreas 2011, 40: 1070-1072. PMID: 21705942, DOI: 10.1097/mpa.0b013e31821f65e3.Peer-Reviewed Original ResearchConceptsCross-sectional imagingInitial cross-sectional imagingPancreas cystic lesionsDifferent surgical fieldsCystic lesionsSurgical fieldRetrospective reviewSerous cystadenomaEndoscopic ultrasoundMain pancreatic duct dilationFine needle aspiration cytologyPancreatic duct dilationEndoscopic ultrasound examinationPancreatic cystic lesionsPresence of cystsLow-risk characteristicsMagnetic resonance imagingWall nodularityDuct dilationResection marginsEUS findingsTomographic scanCyst sizeUltrasound examinationAspiration cytologyEndoscopic Ultrasound and Endoscopic Retrograde Cholangiopancreatography for Obstructing Pancreas Head Masses
Aslanian HR, Estrada JD, Rossi F, Dziura J, Jamidar PA, Siddiqui UD. Endoscopic Ultrasound and Endoscopic Retrograde Cholangiopancreatography for Obstructing Pancreas Head Masses. Journal Of Clinical Gastroenterology 2011, 45: 711-713. PMID: 21301359, DOI: 10.1097/mcg.0b013e3182045923.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnesthesia, GeneralBiopsy, Fine-NeedleChi-Square DistributionCholangiopancreatography, Endoscopic RetrogradeConnecticutConscious SedationDrainageEndosonographyFeasibility StudiesHumansJaundice, ObstructiveMiddle AgedPancreatic NeoplasmsPredictive Value of TestsRetrospective StudiesStentsTime FactorsTreatment OutcomeConceptsEndoscopic retrograde cholangiopancreatographyEndoscopic ultrasoundFine-needle aspirationObstructive jaundiceRetrograde cholangiopancreatographyStent placementEUS-FNAEUS-guided fine-needle aspirationPancreas head massTertiary referral hospitalBiliary stent placementEUS-FNA diagnosisDiagnostic EUS-FNAPlacement success rateOnly complicationReferral hospitalSedative medicationsBiliary stentingConsecutive patientsMedian timePatient evaluationERCP proceduresSame sedationProcedure durationProcedure lengthLong-term Results of an Obesity Program in an Ethnically Diverse Pediatric Population
Savoye M, Nowicka P, Shaw M, Yu S, Dziura J, Chavent G, O'Malley G, Serrecchia JB, Tamborlane WV, Caprio S. Long-term Results of an Obesity Program in an Ethnically Diverse Pediatric Population. Pediatrics 2011, 127: 402-410. PMID: 21300674, PMCID: PMC3065145, DOI: 10.1542/peds.2010-0697.Peer-Reviewed Original ResearchConceptsControl groupLow-density lipoprotein cholesterolTotal body fat massIntensive lifestyle programIntensive lifestyle interventionHomeostasis model assessmentActive intervention phaseWeight management programBody fat massLong-term resultsBMI z-scorePercent body fatDiverse pediatric populationFamily-based programsLifestyle interventionLipoprotein cholesterolTotal cholesterolObese childrenObese populationPediatric populationInsulin resistanceObesity programLifestyle programFat massIntervention group
2010
Renal Ultrasonography in the Evaluation of Acute Kidney Injury: Developing a Risk Stratification Framework
Licurse A, Kim MC, Dziura J, Forman HP, Formica RN, Makarov DV, Parikh CR, Gross CP. Renal Ultrasonography in the Evaluation of Acute Kidney Injury: Developing a Risk Stratification Framework. JAMA Internal Medicine 2010, 170: 1900-1907. PMID: 21098348, DOI: 10.1001/archinternmed.2010.419.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedCreatinineCross-Sectional StudiesDecision Support TechniquesFemaleHospitalizationHumansHydronephrosisKidneyLikelihood FunctionsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsRacial GroupsRecurrenceRetrospective StudiesRisk AssessmentRisk FactorsUltrasonographyUreteral ObstructionUrinary Tract InfectionsConceptsAcute kidney injuryKidney injuryAdult inpatientsIncidental findingPrerenal acute kidney injuryRecurrent urinary tract infectionsMultivariable logistic regression modelYale-New Haven HospitalHistory of hydronephrosisElevated creatinine levelRenal transplant recipientsCongestive heart failureUrinary tract infectionHigh-risk groupLow-risk groupCross-sectional studyLogistic regression modelsNephrotoxic medicationsTransplant recipientsClinical characteristicsCreatinine levelsNonblack raceRenal ultrasonographyTract infectionsHeart failure
2009
Relationship of Serum S100B Levels and Intracranial Injury in Children With Closed Head Trauma
Bechtel K, Frasure S, Marshall C, Dziura J, Simpson C. Relationship of Serum S100B Levels and Intracranial Injury in Children With Closed Head Trauma. Pediatrics 2009, 124: e697-e704. PMID: 19786430, DOI: 10.1542/peds.2008-1493.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsBiomarkersBrain InjuriesCase-Control StudiesChildChild, PreschoolEmergency Service, HospitalFemaleFollow-Up StudiesFractures, BoneGlasgow Coma ScaleHead Injuries, ClosedHumansInjury Severity ScoreMaleMultiple TraumaNerve Growth FactorsPredictive Value of TestsProbabilityRetrospective StudiesRisk AssessmentS100 Calcium Binding Protein beta SubunitS100 ProteinsSex FactorsSurvival AnalysisTomography, X-Ray ComputedConceptsLong bone fracturesTime of venipunctureSerum S100B measurementClosed head traumaIntracranial injurySerum S100B levelsS100B levelsS100B measurementHead traumaUrban pediatric emergency departmentMean S100B levelsLevels of S100BPediatric emergency departmentYears of ageReferral hospitalSerum levelsEmergency departmentCranial CTSkeletal injuriesAnalysis of covarianceBone fracturesInjuryNonwhite childrenVenipunctureChildren
2008
The paradox of the pouch: prompt emptying predicts improved weight loss after laparoscopic Roux-Y gastric bypass
Akkary E, Sidani S, Boonsiri J, Yu S, Dziura J, Duffy AJ, Bell RL. The paradox of the pouch: prompt emptying predicts improved weight loss after laparoscopic Roux-Y gastric bypass. Surgical Endoscopy 2008, 23: 790. PMID: 18806946, DOI: 10.1007/s00464-008-0069-8.Peer-Reviewed Original ResearchConceptsWeight lossGastric bypassLaparoscopic RouxOperative timeGastric pouchSlow emptyingAnalysis of covarianceBody mass index lossLinear stapler techniqueUpper gastrointestinal evaluationGroup B patientsPostoperative day 1Postoperative weight lossInfluences weight lossLength of stayMore weight lossAnastomotic edemaUGI studiesProspective databaseRate of contrastB patientsGastrointestinal evaluationPatient demographicsSingle surgeonNormal gastric
2006
Is It Safe to Delay Appendectomy in Adults With Acute Appendicitis?
Ditillo MF, Dziura JD, Rabinovici R. Is It Safe to Delay Appendectomy in Adults With Acute Appendicitis? Annals Of Surgery 2006, 244: 656-660. PMID: 17060754, PMCID: PMC1856602, DOI: 10.1097/01.sla.0000231726.53487.dd.Peer-Reviewed Original ResearchConceptsAcute appendicitisOnset of symptomsAdvanced pathologyAdult patientsPrompt appendectomyPostoperative complicationsEmergency roomAntibiotic treatmentProgressive pathologyRight lower quadrantRisk of progressionLength of stayStandard of careGangrenous acute appendicitisHigher pathology gradeTotal intervalDegree of pathologyElective mannerHospital intervalHospital delayHospital stayAntibiotic therapyPediatric patientsRetrospective reviewPathologic findings