Tumorigenic and Prognostic Significance of RASSF1A Expression in Low-grade (WHO Grade 1 and Grade 2) Nonmuscle-invasive Bladder Cancer
Ha Y, Jeong P, Kim J, Kwon W, Kim I, Yun S, Kim G, Choi Y, Moon S, Kim W. Tumorigenic and Prognostic Significance of RASSF1A Expression in Low-grade (WHO Grade 1 and Grade 2) Nonmuscle-invasive Bladder Cancer. Urology 2012, 79: 1411.e1-1411.e6. PMID: 22446336, DOI: 10.1016/j.urology.2012.01.042.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternDNA MethylationHumansPrognosisTumor Suppressor ProteinsUrinary Bladder NeoplasmsConceptsLow-grade nonmuscle-invasive bladder cancersNonmuscle invasive bladder cancerPolymerase chain reactionBladder cancerTumor tissueMultivariate Cox regression analysisMRNA expressionTissue levelsRASSF1A expressionCox regression analysisKaplan-Meier estimatesChain reactionNormal bladder mucosaTumor tissue levelsNormal tissue levelsReal-time polymerase chain reactionRASSF1A promoter methylationQuantitative real-time polymerase chain reactionMethylation-specific polymerase chain reactionEffect of RASSF1AT ratioIndependent predictorsPrognostic significancePrognostic valueLarge tumorsRas Association Domain Family 1A: A Promising Prognostic Marker in Recurrent Nonmuscle Invasive Bladder Cancer
Kim J, Chae Y, Ha Y, Kim I, Byun S, Yun S, Kim W. Ras Association Domain Family 1A: A Promising Prognostic Marker in Recurrent Nonmuscle Invasive Bladder Cancer. Clinical Genitourinary Cancer 2012, 10: 114-120. PMID: 22382007, DOI: 10.1016/j.clgc.2011.12.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Transitional CellChildDNA MethylationFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPrognosisPromoter Regions, GeneticProportional Hazards ModelsTumor BurdenTumor Suppressor ProteinsUrinary Bladder NeoplasmsYoung AdultConceptsRecurrent nonmuscle invasive bladder cancerNonmuscle invasive bladder cancerMuscle-invasive bladder cancerInvasive bladder cancerPrimary BC tissuesCox regression analysisBladder cancerPrognostic markerRASSF1A methylationRASSF1A hypermethylationIndependent predictorsBC tissuesMultivariate Cox regression analysisCancer progressionKaplan-Meier analysisAdvanced tumor stagePromising prognostic markerPromoter hypermethylationPotential prognostic markerRegression analysisRASSF1A promoter hypermethylationMethylation-specific polymerase chain reactionClinicopathologic featuresPrognostic significanceKaplan-Meier