2022
Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation
Kwon HK, Dussik CM, Kim SH, Kyriakides TR, Oh I, Lee FY. Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation. Frontiers In Cellular And Infection Microbiology 2022, 12: 897291. PMID: 35755835, PMCID: PMC9218192, DOI: 10.3389/fcimb.2022.897291.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsArthritis, InfectiousDisease Models, AnimalInflammationMiceOsteolysisRifampinConceptsSeptic arthritisBacterial burdenAntibiotic treatmentMurine modelTherapeutic goalsConcurrent antimicrobial therapyDistinct therapeutic goalsGeneration of inflammationMRSA septic arthritisSeptic knee arthritisInflammatory joint conditionsArticular cartilageMitigation of inflammationPost-antibiotic treatmentNovel therapeutic strategiesSeptic arthritis modelArticular cartilage damageEx vivo modelArticular cartilage integrityInflammatory arthritisInhibitors of ERKInflammatory profileMRSA infectionSynovial tissueExcessive inflammation
2019
Effects of Type II Diabetes Mellitus on Tendon Homeostasis and Healing
Nichols AEC, Oh I, Loiselle AE. Effects of Type II Diabetes Mellitus on Tendon Homeostasis and Healing. Journal Of Orthopaedic Research® 2019, 38: 13-22. PMID: 31166037, PMCID: PMC6893090, DOI: 10.1002/jor.24388.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, Type 2Disease Models, AnimalHomeostasisHumansTendinopathyTendon InjuriesTendonsWound HealingConceptsTendon healingTendon functionType II diabetes mellitusPro-inflammatory environmentPre-clinical modelsNovel therapeutic strategiesPotential treatment approachRisk of ruptureHealth care challengesDiabetic tendinopathyDiabetes mellitusDiabetic patientsChronic tendinopathyAcute traumaTendon tearsImpaired restorationPathological progressionTendon repairTherapeutic strategiesTreatment approachesTendon structureUS populationCare challengesNative tendon structureHealing