2021
Comparative study of culture, next‐generation sequencing, and immunoassay for identification of pathogen in diabetic foot ulcer
Lipof JS, Jones CMC, Daiss J, Oh I. Comparative study of culture, next‐generation sequencing, and immunoassay for identification of pathogen in diabetic foot ulcer. Journal Of Orthopaedic Research® 2021, 39: 2638-2645. PMID: 33543785, PMCID: PMC8339135, DOI: 10.1002/jor.25001.Peer-Reviewed Original ResearchConceptsDiabetic foot infectionsMusculoskeletal infectionsNext-generation sequencingS. agalactiaeS. aureusCulture-directed antibioticsDeep musculoskeletal infectionNegative initial culturesProspective observational studyTime of diagnosisDiabetic foot ulcersLimb salvage effortsPeripheral blood samplesYears of ageFoot infectionsSurgical debridementFoot ulcersRecurrent infectionsTreatment successFair correlationIntraoperative samplesObservational studyBlood samplesUseful adjunctOrthopaedic surgeons
2020
Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant‐associated bone infection in mice
Masters EA, Hao SP, Kenney HM, Morita Y, Galloway CA, de Mesy Bentley K, Ricciardi BF, Boyce BF, Schwarz EM, Oh I. Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant‐associated bone infection in mice. Journal Of Orthopaedic Research® 2020, 39: 389-401. PMID: 33336806, PMCID: PMC7882123, DOI: 10.1002/jor.24962.Peer-Reviewed Original ResearchConceptsS. aureus osteomyelitisBone infectionS. agalactiaeAnimal modelsS. aureus bone infectionImplant looseningSoft tissueImplant-associated osteomyelitisQuantitative animal modelCortical boneAdjacent soft tissuesGroup B streptococciS. aureusSeptic implant looseningS. agalactiae infectionAssessment of miceS. aureus virulenceGreater body weightDevastating complicationClinical featuresAbscess formationLocal inflammationAggressive osteolysisLess osteolysisPreclinical modelsSpecies-Specific Immunoassay for Diagnosis and Tracking Treatment Response in Foot and Ankle Infection
Oh I, Hao S, Waldman O, Holleran A, Daiss J. Species-Specific Immunoassay for Diagnosis and Tracking Treatment Response in Foot and Ankle Infection. Foot & Ankle Orthopaedics 2020, 5: 2473011420s00372. PMCID: PMC8702934, DOI: 10.1177/2473011420s00372.Peer-Reviewed Original ResearchAnkle infectionWound healing statusHealing statusDFU patientsOngoing infectionTreatment responseS. aureusDiabetic foot ulcer patientsFellowship-trained orthopedic footFoot ulcer patientsCharacteristic curve analysisDiagnostic toolSpecies-specific immunoassayReliable diagnostic toolOrthopaedic FootSpecific diagnostic toolsUlcer patientsAntibiotic therapyClinical resolutionSurgical treatmentClinical outcomesInitial presentationAntibody titersSerum antibodiesAnkle surgeons
2018
Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes
de Mesy Bentley KL, MacDonald A, Schwarz EM, Oh I. Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes. JBJS Case Connector 2018, 8: e8. PMID: 29443819, PMCID: PMC6681818, DOI: 10.2106/jbjs.cc.17.00154.Peer-Reviewed Original Research