2023
Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection
Agidigbi T, Kwon H, Knight J, Zhao D, Lee F, Oh I. Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection. Frontiers In Cellular And Infection Microbiology 2023, 13: 1198115. PMID: 37434783, PMCID: PMC10332306, DOI: 10.3389/fcimb.2023.1198115.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersPeripheral blood mononuclear cellsHost immune responseActive infectionImmune responseDiabetic foot ulcer infectionsInfected diabetic foot ulcersFoot ulcer infectionsPatients 8 weeksIntravenous antibiotic therapyBlood mononuclear cellsWound healing statusDFU infectionsPBMC expressionSalvage therapyUlcer infectionDifferent time pointsAntibiotic therapyMajor complicationsSurgical treatmentFoot ulcersMononuclear cellsPotential intervention optionsSpecies-specific infectionTreatment response
2021
Next-Generation Sequencing for Pathogen Identification in Infected Foot Ulcers
Choi Y, Oda E, Waldman O, Sajda T, Beck C, Oh I. Next-Generation Sequencing for Pathogen Identification in Infected Foot Ulcers. Foot & Ankle Orthopaedics 2021, 6: 24730114211026933. PMID: 35097461, PMCID: PMC8702686, DOI: 10.1177/24730114211026933.Peer-Reviewed Original ResearchDiabetic foot ulcersFoot infectionsFoot ulcersNext-generation sequencingOrthopedic infectionsInfected diabetic foot ulcersFellowship-trained orthopedic footPostoperative antibiotic treatmentInfected foot ulcersStandard cultureConventional cultureWarrants further investigationManagement of footDFU patientsOrthopaedic FootOperative treatmentKnee amputationAntibiotic treatmentRay amputationOperative procedureAnkle surgeonsCommon pathogensAverage ageCommon microorganismsConcordance rate
2020
Group B Streptococcus Infected Tenosynovitis in Diabetic Foot Ulcers
Waldman O, Sajda T, Oh I, Sulovari A. Group B Streptococcus Infected Tenosynovitis in Diabetic Foot Ulcers. Foot & Ankle Orthopaedics 2020, 5: 2473011420s00483. PMCID: PMC8702881, DOI: 10.1177/2473011420s00483.Peer-Reviewed Original ResearchDiabetic foot ulcersPost-operative complicationsDFU patientsGBS patientsUnplanned readmissionInflammatory markersRay amputationAcute ulcersSurgical treatmentClinical outcomesFoot ulcersRepeat operationSevere soft tissue inflammationInfected diabetic foot ulcersSevere soft tissue damageElevated inflammatory markersHigh inflammatory markersAggressive surgical treatmentSoft tissue inflammationPost-surgical complicationsOrthopaedic surgeon's practiceGroup B streptococciSoft tissue damageBlood glucose valuesFrequent wound complications
2018
Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes
de Mesy Bentley KL, MacDonald A, Schwarz EM, Oh I. Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes. JBJS Case Connector 2018, 8: e8. PMID: 29443819, PMCID: PMC6681818, DOI: 10.2106/jbjs.cc.17.00154.Peer-Reviewed Original Research
2017
Microbiome Analysis for Assessments of Treatment Response and Salvage Prognosis in Infected Diabetic Foot Ulcers
MacDonald A, Oh I, Grier A, Smith B, Daiss J, Gill S. Microbiome Analysis for Assessments of Treatment Response and Salvage Prognosis in Infected Diabetic Foot Ulcers. Foot & Ankle Orthopaedics 2017, 2: 2473011417s000060. DOI: 10.1177/2473011417s000060.Peer-Reviewed Original ResearchIntravenous antibiotic treatmentAntibiotic treatmentNon-traumatic lower extremity amputationsInfected diabetic foot ulcersAdequate prognostic informationPoor prognostic signDiabetic foot ulcersLower extremity amputationSignificant differencesMicrobiome analysisDFU infectionsFoot salvageWagner classificationMedical comorbiditiesCounseling patientsFoot ulcersInitial presentationPrognostic signPrognostic valueActive infectionDiabetic footPrognostic informationClinical signsWeek 8Surgical decision