2024
Clinical challenges and advancements in diagnosing Staphylococcus aureus-associated musculoskeletal infections
Oh I. Clinical challenges and advancements in diagnosing Staphylococcus aureus-associated musculoskeletal infections. Kosin Medical Journal 2024, 39: 5-17. DOI: 10.7180/kmj.24.104.Peer-Reviewed Original ResearchMusculoskeletal infectionsS. aureus immune evasionIdentification of pathogensNext-generation sequencingConventional culture methodsComplicated clinical decisionsDevelopment of innovative diagnosticsPeripheral blood mononuclear cellsRemoval of infected implantsErythrocyte sedimentation rateMonitoring treatment responseTranscriptome of peripheral blood mononuclear cellsBlood mononuclear cellsC-reactive proteinFalse-negative resultsStaphylococcus aureusDominant pathogenAntibiotic therapySurgical debridementAbscess formationInfected implantsInflammatory markersAggressive debridementInfected tissuesOrthopedic infections
2020
Species-Specific Immunoassay Aids Identification of Pathogen and Tracks Infectivity in Foot Infection
Hao SP, Masters EA, Ninomiya MJ, Beck CA, Schwarz EM, Daiss JL, Oh I. Species-Specific Immunoassay Aids Identification of Pathogen and Tracks Infectivity in Foot Infection. Foot & Ankle International 2020, 42: 363-372. PMID: 33161780, PMCID: PMC7946706, DOI: 10.1177/1071100720965136.Peer-Reviewed Original ResearchConceptsFoot infectionsHost immune responseWound healing statusImmune responseHealing statusFoot ulcer patientsProspective comparative studyCulture-positive patientsCulture-negative patientsSpecific serum antibodiesDominant pathogenAnalysis of serumConventional bacterial cultureUlcer patientsMusculoskeletal infectionsSurgical interventionAntibody titersSerum antibodiesTherapeutic responseInfection diagnosisSpecies-specific immunoassaySurgeon's decisionCulture resultsInfectionLevel II