2024
Clinical challenges and advancements in diagnosing Staphylococcus aureus-associated musculoskeletal infections
Oh I. Clinical challenges and advancements in diagnosing Staphylococcus aureus-associated musculoskeletal infections. Kosin Medical Journal 2024, 39: 5-17. DOI: 10.7180/kmj.24.104.Peer-Reviewed Original ResearchMusculoskeletal infectionsS. aureus immune evasionIdentification of pathogensNext-generation sequencingConventional culture methodsComplicated clinical decisionsDevelopment of innovative diagnosticsPeripheral blood mononuclear cellsRemoval of infected implantsErythrocyte sedimentation rateMonitoring treatment responseTranscriptome of peripheral blood mononuclear cellsBlood mononuclear cellsC-reactive proteinFalse-negative resultsStaphylococcus aureusDominant pathogenAntibiotic therapySurgical debridementAbscess formationInfected implantsInflammatory markersAggressive debridementInfected tissuesOrthopedic infections
2019
Evidence of differential microbiomes in healing versus non‐healing diabetic foot ulcers prior to and following foot salvage therapy
MacDonald A, Brodell JD, Daiss JL, Schwarz EM, Oh I. Evidence of differential microbiomes in healing versus non‐healing diabetic foot ulcers prior to and following foot salvage therapy. Journal Of Orthopaedic Research® 2019, 37: 1596-1603. PMID: 30908702, PMCID: PMC6659747, DOI: 10.1002/jor.24279.Peer-Reviewed Original ResearchConceptsSalvage therapyQuantitative polymerase chain reactionClinical outcomesClinical toolErythrocyte sedimentation rateFurther surgical interventionC-reactive proteinLower extremity amputationDiabetic foot ulcersEventual clinical outcomeImportant prognostic informationImportant clinical toolDFU patientsFoot salvageFoot ulcersDiabetic footExtremity amputationSurgical interventionPatient counselingAntibiotic treatmentPolymerase chain reactionPrognostic informationClinical signsMicrobiome analysisClinical significance