2024
Stiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodeling
2022
Pressure‐based estimation of right ventricular ejection fraction
Heerdt PM, Singh I, Elassal A, Kheyfets V, Richter MJ, Tello K. Pressure‐based estimation of right ventricular ejection fraction. ESC Heart Failure 2022, 9: 1436-1443. PMID: 35150211, PMCID: PMC8934966, DOI: 10.1002/ehf2.13839.Peer-Reviewed Original ResearchConceptsRight ventricular ejection fractionCardiac magnetic resonance imagingRight heart catheterizationPulmonary arterial hypertensionMagnetic resonance imagingRV pressure waveformsVentricular ejection fractionRV responseEjection fractionMale PAH patientsCardiac MRI measurementsReceiver operator characteristic curvePressure waveformROC curve analysisClinical reference standardOperator characteristic curveSignificant reductionMeasurements of RVEFPAH patientsArterial hypertensionHeart catheterizationSecondary outcomesStudy cohortLimits of agreementBland-Altman analysis
2021
Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension
Elassal A, Steppan J, Charania S, Santhanam L, Singh I, Heerdt PM. Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension. Journal Of Pharmacological And Toxicological Methods 2021, 112: 107102. PMID: 34245885, PMCID: PMC8616781, DOI: 10.1016/j.vascn.2021.107102.Peer-Reviewed Original ResearchConceptsRight ventricular ejection fractionPulmonary arterial hypertensionRV pressure waveformsVentricular ejection fractionEjection fractionDepressed right ventricular ejection fractionClear prognostic significanceRight ventricular pressurePressure waveformVolume measurementsPAH therapyPulmonary hypertensionArterial hypertensionPrognostic significanceBland-Altman analysisVentricular pressureRat modelRV volumesRodent modelsDrug effectsHypertensionDrug developmentBeat intervalsRatsRelevant targetsSex-Related Differences in Dynamic Right Ventricular-Pulmonary Vascular Coupling in Heart Failure With Preserved Ejection Fraction
Singh I, Oliveira RKF, Heerdt PM, Pari R, Systrom DM, Waxman AB. Sex-Related Differences in Dynamic Right Ventricular-Pulmonary Vascular Coupling in Heart Failure With Preserved Ejection Fraction. CHEST Journal 2021, 159: 2402-2416. PMID: 33388286, DOI: 10.1016/j.chest.2020.12.028.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac CatheterizationEchocardiographyExercise ToleranceFemaleFollow-Up StudiesHeart FailureHeart VentriclesHumansIncidenceMalePulmonary ArteryPulmonary Wedge PressureRetrospective StudiesSex DistributionSex FactorsStroke VolumeSystoleUnited StatesVascular ResistanceVentricular Function, RightVentricular PressureConceptsRV-PA couplingRV-PA uncouplingFemale patientsMale patientsPeak VORV contractilityEjection fractionHeart failureRight ventricular-pulmonary vascular couplingRV-pulmonary arterial couplingAge-matched control subjectsInvasive pulmonary hemodynamicsMaximum incremental exercisePulmonary arterial elastanceRV pressure waveformsPeak exercise capacityRight ventricular dysfunctionSingle-beat analysisEnd-systolic elastanceSex-related differencesPA elastanceRV afterloadVentricular dysfunctionAfterload mismatchContractile impairment
2020
Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction
Oakland HT, Joseph P, Elassal A, Cullinan M, Heerdt PM, Singh I. Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction. Pulmonary Circulation 2020, 10: 1-10. PMID: 33282205, PMCID: PMC7691918, DOI: 10.1177/2045894020972273.Peer-Reviewed Original ResearchIsolated post-capillary pulmonary hypertensionPost-capillary pulmonary hypertensionCardiopulmonary exercise testRight heart catheterizationPulmonary vascular capacitanceVE/VCOPulmonary hypertensionEnd-tidal carbon dioxideEjection fractionHeart failureExercise testHeart catheterizationVascular capacitanceCombined preElevated left-sided filling pressuresLeft-sided filling pressuresGender-matched control subjectsOxygen uptake efficiency slopeCarbon dioxide slopeCardiopulmonary exercise testingPulmonary artery complianceEnd-tidal COAdjunct diagnostic toolMaximum oxygen uptakeGreater ventilatoryA Pressure-Based Method for Estimation of Right Ventricular Ejection Fraction in a Rodent Model of Pulmonary Arterial Hypertension
Heerdt P, Charania S, Elassal A, Singh I, Steppan J. A Pressure-Based Method for Estimation of Right Ventricular Ejection Fraction in a Rodent Model of Pulmonary Arterial Hypertension. 2020, a2086-a2086. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2086.Peer-Reviewed Original Research
2019
A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of concept
Heerdt PM, Kheyfets V, Charania S, Elassal A, Singh I. A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of concept. European Respiratory Journal 2019, 55: 1901635. PMID: 31771999, PMCID: PMC7885179, DOI: 10.1183/13993003.01635-2019.Peer-Reviewed Original ResearchConceptsSingle-beat methodEjection fractionEnd-systolic ventricular elastanceRight ventricular ejection fractionRV pressure waveformsRight ventricular contractilityVentricular ejection fractionRV ejection fractionEes/EaVentricular contractilityCardiovascular decompensationVentricular elastancePressure waveformPulmonary Vascular Distensibility and Early Pulmonary Vascular Remodeling in Pulmonary Hypertension
Singh I, Oliveira RKF, Naeije R, Rahaghi FN, Oldham WM, Systrom DM, Waxman AB. Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodeling in Pulmonary Hypertension. CHEST Journal 2019, 156: 724-732. PMID: 31121149, DOI: 10.1016/j.chest.2019.04.111.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionAerobic exercise capacityExercise pulmonary hypertensionPulmonary hypertensionPulmonary vascular distensibilityExercise capacityUnexplained dyspneaControl subjectsVascular distensibilitySex-matched normal control subjectsInvasive pulmonary hemodynamicsRV pressure curveRV-PA couplingRV-PA uncouplingPulmonary vascular remodelingExercise stress testingEes/EaPeak oxygen consumptionNormal control subjectsPressure-flow plotsArterial hypertensionPulmonary hemodynamicsEjection fractionHeart failureRight ventricular