2021
Yale Cancer Center Precision Medicine Tumor Board: molecular findings alter a diagnosis and treatment plan
Gibson JA, Finberg KE, Nalbantoglu I, Cecchini M, Ganzak A, Walther Z, Sklar JL, Eder JP, Goldberg SB. Yale Cancer Center Precision Medicine Tumor Board: molecular findings alter a diagnosis and treatment plan. The Lancet Oncology 2021, 22: 306-307. PMID: 33662283, DOI: 10.1016/s1470-2045(20)30683-5.Peer-Reviewed Original Research
2020
Recurrent Autoimmune Hepatitis and De Novo Autoimmune Hepatitis in the Liver Allograft
González IA, Hartley CP, Nalbantoglu I. Recurrent Autoimmune Hepatitis and De Novo Autoimmune Hepatitis in the Liver Allograft. American Journal Of Clinical Pathology 2020, 155: 435-445. PMID: 33252121, DOI: 10.1093/ajcp/aqaa147.Peer-Reviewed Original ResearchConceptsDe novo AIHOrthotopic liver transplantDe novo autoimmune hepatitisAutoimmune hepatitisNovo autoimmune hepatitisRecurrent AIHRecurrent autoimmune hepatitisGraft survivalPresentation of AIHModerate portal inflammationOverall graft survivalAggressive clinical courseSubmassive necrosisLiver allograftsLiver transplantPortal inflammationSevere hepatitisAggressive treatmentAdvanced fibrosisClinical courseClinicopathologic characteristicsFemale predominanceSevere inflammationHepatitisPatients
2018
Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm
Joseph NM, Brunt EM, Marginean C, Nalbantoglu I, Snover DC, Thung SN, Yeh MM, Umetsu SE, Ferrell LD, Gill RM. Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm. The American Journal Of Surgical Pathology 2018, 42: 1201-1207. PMID: 29975248, DOI: 10.1097/pas.0000000000001110.Peer-Reviewed Original ResearchConceptsHepatic small vessel neoplasmVariant lesionsGNA14 mutationsVascular neoplasmLow-grade vascular neoplasmLow-grade neoplasmsVascular lesionsCavernous hemangiomaInfiltrative natureCytologic atypiaMolecular pathogenesisNeoplasmsPanel sequencingCopy number alterationsHotspot mutationsExome sequencingLesionsPathogenic mutationsSmall vesselsGNAQSame missense mutationNumber alterationsLiverMissense mutationsMutationsThe impact of diet‐induced hepatic steatosis in a murine model of hepatic ischemia/reperfusion injury
Liss KHH, McCommis KS, Chambers KT, Pietka TA, Schweitzer GG, Park SL, Nalbantoglu I, Weinheimer CJ, Hall AM, Finck BN. The impact of diet‐induced hepatic steatosis in a murine model of hepatic ischemia/reperfusion injury. Liver Transplantation 2018, 24: 908-921. PMID: 29729104, PMCID: PMC6097916, DOI: 10.1002/lt.25189.Peer-Reviewed Original ResearchConceptsDiet-induced hepatic steatosisSteatotic liversHepatic steatosisReperfusion injuryLiver diseaseMicrovesicular steatosisMurine modelObesity-associated nonalcoholic fatty liver diseaseHepatic ischemia/reperfusion injuryEnd-stage liver diseaseIschemia/reperfusion injuryNonalcoholic fatty liver diseasePlasma alanine aminotransferase levelsAlanine aminotransferase levelsFatty liver diseaseCriteria donor organsInflammatory cytokine concentrationsPotential therapeutic approachHepatic IRISteatotic graftsLiver transplantationAminotransferase levelsCommon indicationNonalcoholic steatohepatitisOrgan failure
2017
Differentiation of Hepatocellular Carcinoma from Other Hepatic Malignancies in Patients at Risk: Diagnostic Performance of the Liver Imaging Reporting and Data System Version 2014.
Fraum TJ, Tsai R, Rohe E, Ludwig DR, Salter A, Nalbantoglu I, Heiken JP, Fowler KJ. Differentiation of Hepatocellular Carcinoma from Other Hepatic Malignancies in Patients at Risk: Diagnostic Performance of the Liver Imaging Reporting and Data System Version 2014. Radiology 2017, 286: 158-172. PMID: 28853673, DOI: 10.1148/radiol.2017170114.Peer-Reviewed Original ResearchConceptsNon-HCC malignanciesArterial phase hyperenhancementRim arterial phase hyperenhancementPositive predictive valueHepatocellular carcinomaPredictive valueData System (LI-RADS) version 2014Diagnostic performancePopulation of patientsHIPAA-compliant institutional review boardLiver Imaging ReportingLR-5 criteriaMalignant liver massesLI-RADS categoryFisher's exact testInstitutional review boardClinical followExtrahepatic malignanciesPathology findingsCommon findingLiver massExact testIndependent sample t-testMalignancyImaging ReportingHow does it feel to be a pathology resident? Results of a survey on experiences and job satisfaction during pathology residency
Pehlivanoglu B, Hassoy H, Calle C, Dendooven A, Nalbantoglu I, Reshchikova L, Gul G, Doganavsargil B. How does it feel to be a pathology resident? Results of a survey on experiences and job satisfaction during pathology residency. Virchows Archiv 2017, 471: 413-422. PMID: 28624995, DOI: 10.1007/s00428-017-2167-2.Peer-Reviewed Original ResearchConceptsHealth care systemPatient managementClinicians/surgeonsPathology residencyCountry's health care systemCommon reasonGross examinationMedical teamExperienced pathologistsTraining programResidency training programsPathologyCare systemMolecular pathologyPathologistsResidency program directorsPhysical working conditionsWeb-based linkMost respondentsPathology traineesTargeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis
McCommis KS, Hodges WT, Brunt EM, Nalbantoglu I, McDonald WG, Holley C, Fujiwara H, Schaffer JE, Colca JR, Finck BN. Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis. Hepatology 2017, 65: 1543-1556. PMID: 28027586, PMCID: PMC5397348, DOI: 10.1002/hep.29025.Peer-Reviewed Original ResearchConceptsStellate cell activationPeroxisome proliferator-activated receptor γProliferator-activated receptor γNonalcoholic steatohepatitisMitochondrial pyruvate carrier 2Cell activationRodent modelsReceptor γDevelopment of NASHNonalcoholic fatty liver diseaseDose-limiting side effectHepatic stellate cell activationFatty liver diseaseInsulin-sensitizing thiazolidinedionesLiver of miceLiver-specific deletionExpression of markersTrans fatty acidsMetabolic syndromeLiver diseaseHepatocyte dysfunctionHepatic fibrosisLiver fibrosisPharmacologic developmentMouse modelTumor budding in intestinal-type gastric adenocarcinoma is associated with nodal metastasis and recurrence
Olsen S, Jin L, Fields RC, Yan Y, Nalbantoglu I. Tumor budding in intestinal-type gastric adenocarcinoma is associated with nodal metastasis and recurrence. Human Pathology 2017, 68: 26-33. PMID: 28428104, DOI: 10.1016/j.humpath.2017.03.021.Peer-Reviewed Original ResearchConceptsIntestinal-type gastric adenocarcinomaHigher T stageIntestinal-type cancerGastric adenocarcinomaT stageNodal metastasisN stageLymph node statusSubset of patientsPrimary surgical excisionAmount of tumorCancer-related deathLikelihood of recurrenceDiffuse cancersBetter prognosisHistologic typePrognostic featuresSurgical excisionTumor buddingTumor characteristicsNode statusIntestinal tumorsClinical managementColorectal adenocarcinomaTumor grade
2016
Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease
Randolph GJ, Bala S, Rahier JF, Johnson MW, Wang PL, Nalbantoglu I, Dubuquoy L, Chau A, Pariente B, Kartheuser A, Zinselmeyer BH, Colombel JF. Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease. American Journal Of Pathology 2016, 186: 3066-3073. PMID: 27746181, PMCID: PMC5225286, DOI: 10.1016/j.ajpath.2016.07.026.Peer-Reviewed Original ResearchConceptsTertiary lymphoid organsMesenteric lymph nodesLymph nodesCrohn's diseaseLymphatic collecting vesselsInfection-induced tissue damageInnate lymphoid cellsChronic inflammatory stateImmune cell accessHuman intestinal diseasesMesenteric adipose tissueEarly pathological descriptionsAppropriate immunityInflammatory stateLymphoid organsPoor healingIntestinal diseaseLymphoid cellsPathological descriptionAdipose tissueB cellsAnatomical relationshipTissue damageCD specimensLymphatic remodelingCharacterization of Colorectal Cancer Development in Apcmin/+ Mice
Nalbantoglu I, Blanc V, Davidson NO. Characterization of Colorectal Cancer Development in Apcmin/+ Mice. Methods In Molecular Biology 2016, 1422: 309-327. PMID: 27246043, PMCID: PMC5061497, DOI: 10.1007/978-1-4939-3603-8_27.ChaptersConceptsDextran sulfate sodiumCancer developmentCommon pathologic lesionsBile acid supplementationExperimental colorectal cancerColorectal cancer developmentHigh-fat dietColon cancer developmentSulfate sodiumColorectal cancerFat dietAcid supplementationPathologic lesionsTherapeutic aspectsIntestinal neoplasiaC57BL/6J backgroundEnvironmental modifiersExperimental modelMiceExcellent experimental modelTissue processingNeoplasiaLesionsCancerGastrointestinal Parasitosis: Histopathological Insights to Rare But Intriguing Lesions of the Gastrointestinal Tract
Pehlivanoğlu B, Doğanavşargil B, Sezak M, Nalbantoğlu İ, Korkmaz M. Gastrointestinal Parasitosis: Histopathological Insights to Rare But Intriguing Lesions of the Gastrointestinal Tract. Turkish Journal Of Pathology 2016, 32: 82-90. PMID: 27136106, DOI: 10.5146/tjpath.2015.01350.Peer-Reviewed Case Reports and Technical NotesConceptsEosinophils/hpfActive mucosal inflammationMild eosinophilic infiltrateMucosal architectural changesIncrease of eosinophilsInflammatory bowel diseasePresence of inflammationTaenia saginata infectionCharcot-Leyden crystalsF. hepaticaBowel obstructionNonspecific inflammationEosinophilic infiltrateEosinophilic infiltrationMucosal inflammationBowel diseaseMucosal changesStool testLymphoid aggregatesDefinitive diagnosisHistopathological insightsBiopsy specimensCeliac diseaseGranuloma formationIntriguing lesionsHepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential
Gill RM, Buelow B, Mather C, Joseph NM, Alves V, Brunt EM, Liu TC, Makhlouf H, Marginean C, Nalbantoglu I, Sempoux C, Snover DC, Thung SN, Yeh MM, Ferrell LD. Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential. Human Pathology 2016, 54: 143-151. PMID: 27090685, PMCID: PMC5242228, DOI: 10.1016/j.humpath.2016.03.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCell ProliferationClass I Phosphatidylinositol 3-KinasesDiagnosis, DifferentialDNA Mutational AnalysisFemaleGTP-Binding Protein alpha Subunits, Gq-G11Hemangioma, CavernousHemangiosarcomaHumansImmunohistochemistryKi-67 AntigenLiver NeoplasmsMaleMiddle AgedMutationNeoplasm GradingPhosphatidylinositol 3-KinasesPredictive Value of TestsProto-Oncogene Proteins c-mycTerminology as TopicTumor Suppressor Protein p53Vascular NeoplasmsYoung AdultConceptsHepatic small vessel neoplasmMalignant potentialCavernous hemangiomaVascular neoplasmImmunohistochemical stainsProliferative indexKi-67 proliferative indexTumour cell proliferative indexDisseminated intravascular coagulationKasabach-Merritt syndromePossible malignant potentialLow-grade tumorsUncertain malignant potentialRare vascular neoplasmCapture-based next-generation sequencingHistologic differential diagnosisCell proliferative indexC-myc stainingStrong p53Intravascular coagulationComplete resectionHepatic angiosarcomaDifferential diagnosisInfiltrative bordersAngiosarcoma
2015
Outcomes Using Grafts from Donors after Cardiac Death
Doyle MB, Collins K, Vachharajani N, Lowell JA, Shenoy S, Nalbantoglu I, Byrnes K, Garonzik-Wang J, Wellen J, Lin Y, Chapman WC. Outcomes Using Grafts from Donors after Cardiac Death. Journal Of The American College Of Surgeons 2015, 221: 142-152. PMID: 26095563, DOI: 10.1016/j.jamcollsurg.2015.03.053.Peer-Reviewed Original ResearchConceptsIschemic cholangiopathyPrimary nonfunctionRecipient ageLiver transplantationDonor graftsDCD donorsCardiac death liver graftsEnd-stage liver diseaseAdult liver transplantationDCD graft recipientsHepatic artery thrombosisAcute kidney injuryBrain-dead donorsLong-term outcomesWarm ischemia timeCold flushingDCD graftsDCD recipientsMedian ICUArtery thrombosisGraft survivalHospital stayKidney injuryRecipients of donationGraft recipientsIgG4-related sclerosing cholangitis in the absence of autoimmune pancreatitis mimicking extrahepatic cholangiocarcinoma
Lin J, Cummings OW, Greenson JK, House MG, Liu X, Nalbantoglu I, Pai R, Davidson DD, Reuss SA. IgG4-related sclerosing cholangitis in the absence of autoimmune pancreatitis mimicking extrahepatic cholangiocarcinoma. Scandinavian Journal Of Gastroenterology 2015, 50: 447-453. PMID: 25635498, DOI: 10.3109/00365521.2014.962603.Peer-Reviewed Original ResearchConceptsIgG4-positive plasma cells/high-power fieldPlasma cells/high-power fieldHigh-power fieldCells/high power fieldAutoimmune pancreatitisExtrahepatic cholangiocarcinomaSclerosing cholangitisClinicopathological featuresBile duct injuryLymphoid follicle formationPrimary sclerosing cholangitisSecondary sclerosing cholangitisDense lymphoplasmacytic infiltrateEvidence of relapseExtrahepatic bile ductIgG4 serologyDuct injuryLymphoplasmacytic infiltrateRetroperitoneal fibrosisBenign courseBile ductPreoperative diagnosisCholangitisHigh percentageIgG4
2014
Histological features and severity of oxaliplatin‐induced liver injury and clinical associations
Nalbantoglu I, Tan B, Linehan D, Gao F, Brunt E. Histological features and severity of oxaliplatin‐induced liver injury and clinical associations. Journal Of Digestive Diseases 2014, 15: 553-560. PMID: 25060628, DOI: 10.1111/1751-2980.12177.Peer-Reviewed Original ResearchConceptsOxaliplatin-induced liver injuryHigher injury scoresInjury scoreLiver injuryAspartate aminotransferaseElevated preoperative aspartate aminotransferaseShort-term postoperative complicationsSerum liver enzyme levelsColorectal carcinoma liver metastasesAbnormal AST levelsComponent of chemotherapyHepatic sinusoidal injuryPreoperative aspartate aminotransferaseMetastatic colorectal carcinomaLiver enzyme levelsLiver injury scoreBody mass indexLong-term outcomesSinusoidal lining cellsManifestations of injuryLight microscopic lesionsAlkaline phosphatase levelsInjury scoring systemNon-tumor liverLower injury scoresDifferential expression of miR-31 between inflammatory bowel disease and microscopic colitis.
Zhang C, Zhao Z, Osman H, Watson R, Nalbantoglu I, Lin J. Differential expression of miR-31 between inflammatory bowel disease and microscopic colitis. MicroRNA 2014, 3: 155-9. PMID: 25665881, DOI: 10.2174/2211536604666150209115444.Peer-Reviewed Original ResearchConceptsIdiopathic inflammatory bowel diseaseMicroscopic colitisInflammatory bowel diseaseLymphocytic colitisCollagenous colitisMiR-31 expressionBowel diseaseMiR-31Colonic tissueSeparate disease processesMC episodesUlcerative colitisCrohn's diseaseExpression patternsColitisIntermittent episodesNormal controlsDisease processUseful biomarkerDifferential expressionPatientsColon tissuesDistinct entityDiseaseQRT-PCR
2012
Hepatic Hemangiopericytoma/Solitary Fibrous Tumor: A Review of Our Current Understanding and Case Study
Bokshan SL, Doyle M, Becker N, Nalbantoglu I, Chapman WC. Hepatic Hemangiopericytoma/Solitary Fibrous Tumor: A Review of Our Current Understanding and Case Study. Journal Of Gastrointestinal Surgery 2012, 16: 2170-2176. PMID: 22854953, DOI: 10.1007/s11605-012-1947-x.Peer-Reviewed Case Reports and Technical NotesConceptsSolitary fibrous tumorProlonged steroid useSoft tissue tumorsSoft tissue neoplasmWorld Health OrganizationAdjuvant radiotherapyHepatic resectionInoperable casesSteroid useIGF-IICurrent mainstayPainless massMost lesionsVascular neoplasmFibrous tumorMarked hypoglycemiaTissue tumorsDiagnostic modalitiesHemangiopericytomaChemotherapeutic approachesMesenchymal originNeoplasmsHealth OrganizationAntiangiogenic compoundsTumorsTransient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice
Carvalho FA, Koren O, Goodrich JK, Johansson ME, Nalbantoglu I, Aitken JD, Su Y, Chassaing B, Walters WA, González A, Clemente JC, Cullender TC, Barnich N, Darfeuille-Michaud A, Vijay-Kumar M, Knight R, Ley RE, Gewirtz AT. Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice. Cell Host & Microbe 2012, 12: 139-152. PMID: 22863420, PMCID: PMC4310462, DOI: 10.1016/j.chom.2012.07.004.Peer-Reviewed Original ResearchConceptsChronic colitisGenetic influencing factorsTLR5-deficient miceChronic gut inflammationLow-grade inflammationMucosal immune systemInnate immune deficiencyProinflammatory gene expressionWild-type miceContribution of microbiotaTransient high levelsGut inflammationImmune deficiencyIntestinal microbiotaColitisGut microbiotaImmune systemMice displayUnstable microbiotaGut epitheliumTransient inabilityMicrobiotaInflammationBreakdown of homeostasisIncomplete penetrancePositron Emission Tomography with [18F]-3′-Deoxy-3′fluorothymidine (FLT) as a Predictor of Outcome in Patients with Locally Advanced Resectable Rectal Cancer: a Pilot Study
Dehdashti F, Grigsby PW, Myerson RJ, Nalbantoglu I, Ma C, Siegel BA. Positron Emission Tomography with [18F]-3′-Deoxy-3′fluorothymidine (FLT) as a Predictor of Outcome in Patients with Locally Advanced Resectable Rectal Cancer: a Pilot Study. Molecular Imaging And Biology 2012, 15: 106-113. PMID: 22684813, PMCID: PMC3659775, DOI: 10.1007/s11307-012-0566-y.Peer-Reviewed Original ResearchConceptsDisease-free survivalPositron emission tomographyFDG uptakeFLT uptakeRectal cancerAdvanced resectable rectal cancerEmission tomographyImproved disease-free survivalMaximum standardized uptake valuePercentage changePilot studyResectable rectal cancerAdvanced rectal cancerFDG-PET/Predictors of outcomeStandardized uptake valuePurposeThis pilot studyNeoadjuvant chemoradiotherapyProgressive diseaseRegional lymphResultsThirteen patientsFLT-PETHigher percentage changeTumor uptakeUptake value
2011
Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis
Carvalho FA, Nalbantoglu I, Ortega-Fernandez S, Aitken JD, Su Y, Koren O, Walters WA, Knight R, Ley RE, Vijay-Kumar M, Gewirtz AT. Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut 2011, 61: 373. PMID: 21646247, DOI: 10.1136/gut.2011.240556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCecumColitis, UlcerativeDisease Models, AnimalDisease SusceptibilityGene Expression ProfilingInterleukin-1betaMaleMetagenomeMiceMice, KnockoutMyeloid Differentiation Factor 88Receptors, Interleukin-10Reverse Transcriptase Polymerase Chain ReactionSignal TransductionToll-Like Receptor 5ConceptsToll-like receptor 4T5KO miceGut microbiotaColitis modelIL-1βAbsence of TLR4Toll-like receptor 5 deficient (T5KO) miceAnti-inflammatory cytokine interleukin-10Endogenous anti-inflammatory pathwayToll-like receptor 5Loss of TLR5Anti-inflammatory pathwayIL-10 receptorCytokine interleukin-10Double knockoutIL-10 signalingIL-1 receptorProinflammatory gene expressionWild-type littermatesColitogenic microbiotaSpontaneous colitisUniform colitisSevere colitisImmune dysregulationIntestinal inflammation