2021
Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis and hepatocellular cancer
Blanc V, Riordan JD, Soleymanjahi S, Nadeau J, Nalbantoglu I, Xie Y, Molitor EA, Madison BB, Brunt EM, Mills JC, Rubin DC, Ng I, Ha Y, Roberts LR, Davidson NO. Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis and hepatocellular cancer. Journal Of Clinical Investigation 2021, 131 PMID: 33445170, PMCID: PMC7773377, DOI: 10.1172/jci138699.Peer-Reviewed Original ResearchConceptsHuman hepatocellular cancerHigh-fructose dietHepatocellular cancerNonalcoholic fatty liver diseaseFatty liver diseaseExpression of mRNALipogenic gene expressionSpontaneous fibrosisAdvanced fibrosisLiver diseaseLiver functionHepatic steatosisInflammatory pathwaysInflammatory responseFed chowLong-term effectsTissue microarrayHepatic proliferationMRNA expressionFactor overexpressionReduced survivalFibrosisOxidative stressExtracellular matrix organizationSteatosis
2007
The effect of methylprednisolone on warm ischemia-reperfusion injury in the liver
Saidi RF, Chang J, Verb S, Brooks S, Nalbantoglu I, Adsay V, Jacobs MJ. The effect of methylprednisolone on warm ischemia-reperfusion injury in the liver. The American Journal Of Surgery 2007, 193: 345-348. PMID: 17320532, DOI: 10.1016/j.amjsurg.2006.09.017.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryR injuryInterleukin-6Continuous clampingIschemic preconditioningSteatotic liversInflammatory responseNormal liverAspartate aminotransferaseLiver ischemia-reperfusion injuryWarm ischemia-reperfusion injuryMale Sprague-Dawley ratsSerum IL-6Serum interleukin-6Hours of reperfusionEffect of methylprednisoloneCause of morbiditySprague-Dawley ratsIntravenous methylprednisoloneHepatic ischemiaIschemia inductionSerum levelsIschemic controlsIschemic periodLiver ischemia