1993
Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia
Huttemeier P, Kamiyama Y, Su M, Watkins W, Benveniste H. Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia. Prostaglandins 1993, 45: 177-187. PMID: 8430228, DOI: 10.1016/0090-6980(93)90033-4.Peer-Reviewed Original ResearchConceptsCerebral ischemiaPGF1 alphaMicrodialysis probeRat CA1 hippocampusGlobal cerebral ischemiaTransient cerebral ischemiaRole of PGD2Arachidonic acid metabolismAverage peak concentrationDistinct brain regionsIschemic brainEicosanoid concentrationsCA1 hippocampusEicosanoid releaseAA metabolitesPG metabolitesMicrodialysis measurementsBaseline levelsBrain regionsIschemiaPGD2TXB2Implanted microdialysis probesPeak concentrationAcid metabolism
1990
Microdialysis—Theory and application
Benveniste H, Hüttemeier P. Microdialysis—Theory and application. Progress In Neurobiology 1990, 35: 195-215. PMID: 2236577, DOI: 10.1016/0301-0082(90)90027-e.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1989
Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3
Benveniste H, Jørgensen M, Sandberg M, Christensen T, Hagberg H, Diemer N. Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3. Cerebrovascular And Brain Metabolism Reviews 1989, 9: 629-639. PMID: 2570785, DOI: 10.1038/jcbfm.1989.90.Peer-Reviewed Original ResearchConceptsCA1 regionPyramidal cellsGlutamate releaseIntact innervationHippocampal tissueCA1 tissueInjection siteIschemia-induced releaseIschemia-induced damageTransient global ischemiaCA1 pyramidal cellsRelease of glutamateGlutamatergic afferentsIschemic damageHippocampal CA1CA1 pyramidsGlobal ischemiaCA3 regionPathogenetic significanceIschemiaNeurotoxic potentialCA3CA1GlutamateInnervationDetermination of Brain Interstitial Concentrations by Microdialysis
Benveniste H, Hansen A, Ottosen N. Determination of Brain Interstitial Concentrations by Microdialysis. Journal Of Neurochemistry 1989, 52: 1741-1750. PMID: 2723633, DOI: 10.1111/j.1471-4159.1989.tb07252.x.Peer-Reviewed Original ResearchBrain Microdialysis
Benveniste H. Brain Microdialysis. Journal Of Neurochemistry 1989, 52: 1667-1679. PMID: 2656913, DOI: 10.1111/j.1471-4159.1989.tb07243.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1987
Cellular reactions to implantation of a microdialysis tube in the rat hippocampus
Benveniste H, Diemer N. Cellular reactions to implantation of a microdialysis tube in the rat hippocampus. Acta Neuropathologica 1987, 74: 234-238. PMID: 3673515, DOI: 10.1007/bf00688186.Peer-Reviewed Original ResearchConceptsMicrodialysis tubeNumber of astrocytesAdjacent tissue reactionExtracellular neurotransmitter concentrationsNormal neuropilGranuloma formationOccasional hemorrhageRat hippocampusRat dorsalCollagen depositsAstrocyte processesTissue changesNeurotransmitter concentrationsFiber implantationTissue reactionAstrocytesImplantationNeuropilCellular reactionsDaysOptimal timeRegional Cerebral Glucose Phosphorylation and Blood Flow After Insertion of a Microdialysis Fiber Through the Dorsal Hippocampus in the Rat
Benveniste H, Drejer J, Schousboe A, Diemer N. Regional Cerebral Glucose Phosphorylation and Blood Flow After Insertion of a Microdialysis Fiber Through the Dorsal Hippocampus in the Rat. Journal Of Neurochemistry 1987, 49: 729-734. PMID: 3612121, DOI: 10.1111/j.1471-4159.1987.tb00954.x.Peer-Reviewed Original ResearchConceptsLocal cerebral blood flowBlood flowDorsal hippocampusGlucose metabolismMicrodialysis fibersLocal cerebral glucose metabolismCerebral glucose metabolismCerebral blood flowRat dorsal hippocampusGlucose phosphorylationNear normalizationFocal disturbanceRecovery periodPronounced disturbancesHippocampusRatsImplantationMetabolismPhosphorylationRecovery timeGliosisSlight reductionLCMRglcLCMRglu
1985
Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro
Drejer J, Benveniste H, Diemer N, Schousboe A. Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro. Journal Of Neurochemistry 1985, 45: 145-151. PMID: 2860206, DOI: 10.1111/j.1471-4159.1985.tb05486.x.Peer-Reviewed Original ResearchConceptsPotassium-induced releaseGlutamatergic neuronsAspartate uptakeConditions of hypoglycemiaCultured glutamatergic neuronsTransient cerebral ischemiaHigh potassiumExtracellular glutamate contentCerebral ischemiaGlutamate releaseTransmitter poolExtracellular glutamateMicrodialysis techniqueIschemiaBrain tissuePotassium stimulationPerfusion mediumHypoglycemiaGlutamate contentNeuronsInduced increasesCellular originVivo experimentsAstrocytesPrevious reports
1984
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis
Benveniste H, Drejer J, Schousboe A, Diemer N. Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis. Journal Of Neurochemistry 1984, 43: 1369-1374. PMID: 6149259, DOI: 10.1111/j.1471-4159.1984.tb05396.x.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidCerebral ischemiaIschemic periodTransient complete cerebral ischemiaTransient cerebral ischemiaComplete cerebral ischemiaExtracellular contentAmino acid glutamateDiameter dialysisIntracerebral microdialysisConcentrations of alanineExtracellular glutamateRat hippocampusCertain neuronsTaurine concentrationsIschemiaExtracellular concentrationHippocampusExtracellular fluidRinger's solutionGlutamateSame periodAspartateCausal factorsPeriod