2001
Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI Study
McDaniel B, Sheng H, Warner D, Hedlund L, Benveniste H. Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI Study. NeuroImage 2001, 14: 1244-1255. PMID: 11707081, DOI: 10.1006/nimg.2001.0934.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EAtrophyBrainBrain IschemiaBrain MappingCerebral VentriclesDisease Models, AnimalHippocampusImage EnhancementImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMice, Neurologic MutantsMicroscopyNeurodegenerative DiseasesProsencephalonConceptsApoE-deficient miceModels of neurodegenerationPostischemic dayBrain atrophyMouse modelNeurodegenerative diseasesDorsal hippocampal volumeBrain volume changesMin of ischemiaHigh signal intensity areaTransgenic mouse modelProgression of pathologyCorresponding time pointsSignal intensity areaMagnetic resonance imagingHigh-resolution MRIT1-weighted MR imagingC57 miceDorsal hippocampusHippocampal volumeClinical conditionsIschemiaMRI studiesPredetermined protocolCognitive decline
1997
Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy study
Qiu H, Hedlund L, Gewalt S, Benveniste H, Bare T, Johnson G. Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy study. Journal Of Magnetic Resonance Imaging 1997, 7: 739-744. PMID: 9243396, DOI: 10.1002/jmri.1880070421.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryStroke volumeIpsilateral common carotid arteryReduced stroke volumeFocal ischemic lesionsCommon carotid arteryGlycine/NMDA antagonistsMCA occlusionCerebral arteryIschemic lesionsMultiple time pointsNMDA antagonistsCarotid arteryDrug treatmentRat brainGroup 2Group 1Control groupVivo studiesTime pointsZD9379ArteryOcclusionHoursTreatment
1996
A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance Microscopy
Hall W, Benveniste H, Hedlund L, Johnson G. A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance Microscopy. NeuroImage 1996, 3: 158-166. PMID: 9345486, DOI: 10.1006/nimg.1996.0017.Peer-Reviewed Original Research
1993
Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia
Zhang J, Benveniste H, Piantadosi C. Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia. Neuroscience Letters 1993, 157: 179-182. PMID: 7694195, DOI: 10.1016/0304-3940(93)90731-y.Peer-Reviewed Original ResearchConceptsGlutamate releaseGlutamate concentrationNitric oxide synthase inhibitionCerebral glutamate concentrationsOxide synthase inhibitionGlobal brain ischemiaInhibition of NOSNitric oxide synthaseExtracellular glutamate releaseCerebral microdialysisBrain ischemiaForebrain ischemiaControl ratsGlobal ischemiaNOS inhibitorOxide synthaseSynthase inhibitionCarotid arteryBrain flowDialysis probeIschemiaDialysate concentrationsControl valuesRatsReperfusionHydrogen Peroxide Production by Monoamine Oxidase during Ischemia-Reperfusion in the Rat Brain
Simonson S, Zhang J, Canada A, Su Y, Benveniste H, Piantadosi C. Hydrogen Peroxide Production by Monoamine Oxidase during Ischemia-Reperfusion in the Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1993, 13: 125-134. PMID: 8417001, DOI: 10.1038/jcbfm.1993.15.Peer-Reviewed Original ResearchConceptsInhibition of MAOMonoamine oxidaseRat brainMAO inhibitorsForebrain blood flowMin of ischemiaBrain reperfusionIschemia reperfusionCatecholamine concentrationsBlood flowForebrain homogenatesReperfusionIschemiaGlutathione peroxidaseGlutathione concentrationBiochemical indicationsThreefold increaseBrainInhibitorsInhibitionH2O2 productionSurvivalHydrogen peroxide productionCatalasePeroxide productionIschemia as an Excitotoxic Lesion: Protection Against Hippocampal Nerve Cell Loss by Denervation
Diemer N, Johansen F, Benveniste H, Bruhn T, Berg M, Valente E, Jørgensen M. Ischemia as an Excitotoxic Lesion: Protection Against Hippocampal Nerve Cell Loss by Denervation. Acta Neurochirurgica Supplement 1993, 57: 94-101. PMID: 8380675, DOI: 10.1007/978-3-7091-9266-5_14.Peer-Reviewed Original ResearchConceptsPyramidal neuronsIschemic neuron damageVulnerable nerve cellsTransient cerebral ischemiaGABA-ergic interneuronsNerve cell lossMin of ischemiaHippocampal pyramidal neuronsRelease of glutamateExtracellular glutamate releaseKainate/Neuroexcitatory mechanismsNeuron damagePostischemic periodCerebral ischemiaHilus cellsPostischemic hypoperfusionCalcium blockersGlutamate releaseIntact innervationIschemic animalsDenervated ratsDentate hilusReceptor autoradiographyCA1 neurons
1992
Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.
Benveniste H, Hedlund L, Johnson G. Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy. Stroke 1992, 23: 746-754. PMID: 1374575, DOI: 10.1161/01.str.23.5.746.Peer-Reviewed Original ResearchConceptsAcute cerebral ischemiaCerebral ischemiaApparent diffusion coefficientOuabain exposureDiffusion-weighted magnetic resonance microscopyApparent diffusion coefficient reductionRight middle cerebral arteryIpsilateral common carotid arteryN-methyl-D-aspartate exposureFocal cerebral ischemiaMiddle cerebral arteryCommon carotid arteryApparent diffusion coefficient (ADC) valuesRat brain tissueTissue apparent diffusion coefficientCerebral arteryMicrodialysis membraneGlutamate exposureCorpus striatumOlfactory cortexCarotid arterySprague-DawleyBrain tissueIschemiaArtery
1991
Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain.
Benveniste H, Cofer G, Piantadosi C, Davis J, Johnson G. Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain. Stroke 1991, 22: 259-268. PMID: 2003291, DOI: 10.1161/01.str.22.2.259.Peer-Reviewed Original ResearchConceptsSelective neuronal injuryFocal cerebral ischemiaArea of injuryCerebral ischemiaNeuronal injuryTotal slice areaIschemic penumbraWistar ratsRat brainCresyl violet-stained brain sectionsMR imagingUpper cortical layersMale Wistar ratsPermanent unilateral occlusionCommon carotid arteryHistological sectionsArea of infarctionMR imagesNormal brain tissueMagnetic resonance imagingCerebral cortexUnilateral occlusionHistological damageHalothane anesthesiaCarotid arteryThe excitotoxin hypothesis in relation to cerebral ischemia.
Benveniste H. The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovascular And Brain Metabolism Reviews 1991, 3: 213-45. PMID: 1931486.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsSelective neuronal deathExcitotoxin hypothesisNeuronal deathExtracellular glutamate concentration increasesSelective vulnerable brain regionsBrain regionsN-methyl-D-aspartate receptorsGlutamate accumulationBrain cell injuryVulnerable brain regionsTransient global ischemiaHigh-performance liquid chromatographyDistinct brain regionsNeuronal injuryBrain extracellular spaceCerebral ischemiaTransient ischemiaAntagonist APVExcitatory neurotransmitterGlobal ischemiaExtracellular glutamateNMDA antagonistsCertain neuronsMicrodialysis technique
1989
Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3
Benveniste H, Jørgensen M, Sandberg M, Christensen T, Hagberg H, Diemer N. Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3. Cerebrovascular And Brain Metabolism Reviews 1989, 9: 629-639. PMID: 2570785, DOI: 10.1038/jcbfm.1989.90.Peer-Reviewed Original ResearchConceptsCA1 regionPyramidal cellsGlutamate releaseIntact innervationHippocampal tissueCA1 tissueInjection siteIschemia-induced releaseIschemia-induced damageTransient global ischemiaCA1 pyramidal cellsRelease of glutamateGlutamatergic afferentsIschemic damageHippocampal CA1CA1 pyramidsGlobal ischemiaCA3 regionPathogenetic significanceIschemiaNeurotoxic potentialCA3CA1GlutamateInnervation
1988
Early Postischemic 45Ca Accumulation in Rat Dentate Hilus
Benveniste H, Diemer N. Early Postischemic 45Ca Accumulation in Rat Dentate Hilus. Cerebrovascular And Brain Metabolism Reviews 1988, 8: 713-719. PMID: 3417798, DOI: 10.1038/jcbfm.1988.118.Peer-Reviewed Original Research