2009
Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus
Wagshul M, McAllister J, Rashid S, Li J, Egnor M, Walker M, Yu M, Smith S, Zhang G, Chen J, Benveniste H. Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus. Experimental Neurology 2009, 218: 33-40. PMID: 19348801, DOI: 10.1016/j.expneurol.2009.03.034.Peer-Reviewed Original ResearchConceptsVentricular dilationAqueductal flowVentricular volumeInjection of kaolinNew experimental modelCSF pulsatilityClinical presentationMild ventriculomegalyVentricular sizeBasal cisternsChronic elevationAbnormal pulsationsCerebral aqueductHydrocephalic animalsEffective treatmentAdult ratsIntact controlsNormal levelsHydrocephalusExperimental modelT MRIRatsMonth periodVentriculomegalyDilation
1997
Extracellular glutamate and dopamine measured by microdialysis in the rat striatum during blockade of synaptic transmission in anesthetized and awake rats
Shiraishi M, Kamiyama Y, Hüttemeier P, Benveniste H. Extracellular glutamate and dopamine measured by microdialysis in the rat striatum during blockade of synaptic transmission in anesthetized and awake rats. Brain Research 1997, 759: 221-227. PMID: 9221940, DOI: 10.1016/s0006-8993(97)00258-8.Peer-Reviewed Original ResearchConceptsGlutamate levelsExtracellular glutamateAwake ratsMicrodialysis probeExtracellular striatal glutamateHalothane-anesthetized ratsNormal female ratsEffects of anesthesiaLower glutamate levelsTTX concentrationsStriatal glutamateBrain interstitialBrain metabolismDialysate dopamineFemale ratsSynaptic transmissionRat striatumMicrodialysis measurementsNeurotoxic potentialTetrodotoxinRatsNon-stimulated conditionsProbe implantationGlutamateAnesthesia
1995
Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion.
Zhang J, Benveniste H, Klitzman B, Piantadosi C. Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke 1995, 26: 298-304. PMID: 7530389, DOI: 10.1161/01.str.26.2.298.Peer-Reviewed Original ResearchConceptsIschemia/reperfusionBlood-brain barrierCerebral blood flowBrain ischemia/reperfusionExcitatory amino acidsExtracellular glutamate concentrationL-NAMEBlood flowGlutamate concentrationSynthase inhibitionL-arginineExcitatory amino acid toxicityL-NAME-treated ratsPostischemic cerebral blood flowNitric oxide synthase inhibitionCerebral ischemia/reperfusionBlood-brain barrier functionL-arginine methyl esterCerebral blood flow responseBlood-brain barrier permeabilityGlobal brain ischemia/reperfusionElevated glutamate concentrationsImmediate postischemic periodInterstitial glutamate concentrationL-NAME administration
1993
Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia
Zhang J, Benveniste H, Piantadosi C. Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia. Neuroscience Letters 1993, 157: 179-182. PMID: 7694195, DOI: 10.1016/0304-3940(93)90731-y.Peer-Reviewed Original ResearchConceptsGlutamate releaseGlutamate concentrationNitric oxide synthase inhibitionCerebral glutamate concentrationsOxide synthase inhibitionGlobal brain ischemiaInhibition of NOSNitric oxide synthaseExtracellular glutamate releaseCerebral microdialysisBrain ischemiaForebrain ischemiaControl ratsGlobal ischemiaNOS inhibitorOxide synthaseSynthase inhibitionCarotid arteryBrain flowDialysis probeIschemiaDialysate concentrationsControl valuesRatsReperfusionMicrodialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia
Huttemeier P, Kamiyama Y, Su M, Watkins W, Benveniste H. Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia. Prostaglandins 1993, 45: 177-187. PMID: 8430228, DOI: 10.1016/0090-6980(93)90033-4.Peer-Reviewed Original ResearchConceptsCerebral ischemiaPGF1 alphaMicrodialysis probeRat CA1 hippocampusGlobal cerebral ischemiaTransient cerebral ischemiaRole of PGD2Arachidonic acid metabolismAverage peak concentrationDistinct brain regionsIschemic brainEicosanoid concentrationsCA1 hippocampusEicosanoid releaseAA metabolitesPG metabolitesMicrodialysis measurementsBaseline levelsBrain regionsIschemiaPGD2TXB2Implanted microdialysis probesPeak concentrationAcid metabolismHydrogen Peroxide Production by Monoamine Oxidase during Ischemia-Reperfusion in the Rat Brain
Simonson S, Zhang J, Canada A, Su Y, Benveniste H, Piantadosi C. Hydrogen Peroxide Production by Monoamine Oxidase during Ischemia-Reperfusion in the Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1993, 13: 125-134. PMID: 8417001, DOI: 10.1038/jcbfm.1993.15.Peer-Reviewed Original ResearchMeSH KeywordsAmitroleAnimalsBrain IschemiaCatalaseGlutathioneHydrogen PeroxideMaleMonoamine OxidaseRatsRats, Sprague-DawleyReactive Oxygen SpeciesReperfusion InjuryConceptsInhibition of MAOMonoamine oxidaseRat brainMAO inhibitorsForebrain blood flowMin of ischemiaBrain reperfusionIschemia reperfusionCatecholamine concentrationsBlood flowForebrain homogenatesReperfusionIschemiaGlutathione peroxidaseGlutathione concentrationBiochemical indicationsThreefold increaseBrainInhibitorsInhibitionH2O2 productionSurvivalHydrogen peroxide productionCatalasePeroxide production