2020
Computational Models of Drug Use and Addiction: A Review
Mollick JA, Kober H. Computational Models of Drug Use and Addiction: A Review. Journal Of Psychopathology And Clinical Science 2020, 129: 544-555. PMID: 32757599, PMCID: PMC7416739, DOI: 10.1037/abn0000503.Peer-Reviewed Original ResearchMeSH KeywordsBehavior, AddictiveBrainComputer SimulationHumansLearningModels, NeurologicalMotivationSubstance-Related DisordersConceptsBrain-based modelsBehavioral controlComputational modelGoal-directed systemAspects of addictionCurrent computational modelsExecutive control circuitPredictive coding approachSymptoms of addictionModel of learningComputational accountPrediction errorComputational theoryPrefrontal cortexDrug useBrain areasDorsal striatumAddictionDopamine systemEffects of drugsBasal gangliaHuman dataCoding approachesBroad categoriesMotivation
2010
Prefrontal–striatal pathway underlies cognitive regulation of craving
Kober H, Mende-Siedlecki P, Kross EF, Weber J, Mischel W, Hart CL, Ochsner KN. Prefrontal–striatal pathway underlies cognitive regulation of craving. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14811-14816. PMID: 20679212, PMCID: PMC2930456, DOI: 10.1073/pnas.1007779107.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersPrefrontal cortexVentral tegmental areaSubstance-dependent populationsMore effective treatmentsLong-term consumptionDorsolateral prefrontal cortex activityPrefrontal cortex activityCigarette smokersTegmental areaVentrolateral prefrontal cortexVentral striatum activityVentral striatal activitySubgenual cingulateEffective treatmentLateral prefrontal cortexStriatal activityVentral striatumCortex activityFunctional imagingPhysical healthStriatum activityNeural activityCortex