2021
Tumor suppressor p53 regulates intestinal type 2 immunity
Chang C, Wang J, Zhao Y, Liu J, Yang X, Yue X, Wang H, Zhou F, Inclan-Rico J, Ponessa J, Xie P, Zhang L, Siracusa M, Feng Z, Hu W. Tumor suppressor p53 regulates intestinal type 2 immunity. Nature Communications 2021, 12: 3371. PMID: 34099671, PMCID: PMC8184793, DOI: 10.1038/s41467-021-23587-x.Peer-Reviewed Original ResearchConceptsType 2 immunityRole of p53Parasitic infectionsInnate lymphoid cell responsesLymphoid cell responsesImmune integrityInfection of parasitesNippostrongylus brasiliensisTuft cellsCell responsesImmunityInfectionTritrichomonas murisTumor suppressor p53P53Unrecognized functionTumor suppressionSuppressor p53Critical triggerCritical roleCell circuitRoleResponse
2020
LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome
Wang H, Wang J, Zhao Y, Zhang X, Liu J, Zhang C, Haffty B, Verzi M, Zhang L, Gao N, Feng Z, Hu W. LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. Cell Death & Disease 2020, 11: 588. PMID: 32719388, PMCID: PMC7385639, DOI: 10.1038/s41419-020-02790-6.Peer-Reviewed Original ResearchConceptsRadiation-induced GI syndromeLeukemia inhibitory factorIntestinal epitheliumIntestinal stem cellsLIF deficiencyGI syndromeGastrointestinal syndromeFunction of ISCsRadiation-induced gastrointestinal syndromeRecombinant leukemia inhibitory factorRecombinant LIFWild-type miceISC functionLifespan of miceAkt/GSK3βIntestinal epithelial regenerationIntestinal epithelial homeostasisStem cellsProlong survivalWT miceAdult intestinal epitheliumRadioprotective roleΒ-catenin activityCytokine essentialHigh doses
2013
Altered vascular activation due to deficiency of the NADPH oxidase component p22phox
Wang H, Albadawi H, Siddiquee Z, Stone J, Panchenko M, Watkins M, Stone J. Altered vascular activation due to deficiency of the NADPH oxidase component p22phox. Cardiovascular Pathology 2013, 23: 35-42. PMID: 24035466, DOI: 10.1016/j.carpath.2013.08.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarotid Artery InjuriesCarotid Artery, CommonCase-Control StudiesCasein Kinase IalphaCells, CulturedCoronary VesselsCytochrome b GroupElastic TissueFemaleGranulomatous Disease, ChronicHeterogeneous-Nuclear Ribonucleoprotein Group CHumansHyperplasiaInfantMaleMatrix Metalloproteinase 12MiceMice, KnockoutMuscle, Smooth, VascularNADPH OxidasesNeointimaReactive Oxygen SpeciesRNA InterferenceTissue Inhibitor of Metalloproteinase-1TransfectionConceptsWild-type littermatesElastic fiber lossVascular activationDeficient miceIntimal hyperplasiaNADPH oxidase complexCoronary artery smooth muscle cellsNicotinamide adenine dinucleotide phosphate (NADPH) oxidaseArtery smooth muscle cellsHuman coronary artery smooth muscle cellsAdenine Dinucleotide Phosphate OxidaseBasal blood pressureCarotid artery ligationExpression ratioSmooth muscle cellsLung biopsyBlood pressureFiber lossArtery ligationCarotid ligationCarotid arteryTissue inhibitorHuman patientsMuscle cellsMiceSEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion
Chen X, Wang H, Bajaj K, Zhang P, Meng Z, Ma D, Bai Y, Liu H, Adams E, Baines A, Yu G, Sartor M, Zhang B, Yi Z, Lin J, Young S, Schekman R, Ginsburg D. SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. ELife 2013, 2: e00444. PMID: 23580231, PMCID: PMC3622177, DOI: 10.7554/elife.00444.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins ECell Line, TumorCholesterolCOP-Coated VesiclesDown-RegulationDyslipidemiasEndoplasmic ReticulumEpistasis, GeneticGenotypeHEK293 CellsHumansLiverMice, 129 StrainMice, Inbred C57BLMice, KnockoutMutationPhenotypeProprotein Convertase 9Proprotein ConvertasesProtein TransportReceptors, LDLSerine EndopeptidasesTransfectionVesicular Transport ProteinsConceptsEndoplasmic reticulumCOPII vesicle formationCargo recruitmentCOPII vesiclesCargo proteinsEukaryotic cellsCargo selectivitySecretory pathwaySEC24AEfficient exitUnappreciated heterogeneityNegative regulatorSecretory proteinsVesicle formationPCSK9 secretionComplete genetic deficiencyGenetic deficiencyLDLR levelsProteinVesiclesFundamental roleNormal survivalPartial overlapRecruitmentSEC24B