2020
The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy
Liu D, Badeti S, Dotti G, Jiang JG, Wang H, Dermody J, Soteropoulos P, Streck D, Birge RB, Liu C. The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy. Cell Communication And Signaling 2020, 18: 134. PMID: 32843053, PMCID: PMC7446110, DOI: 10.1186/s12964-020-00617-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkers, TumorClinical Trials as TopicHumansImmunological SynapsesImmunotherapyReceptors, Chimeric AntigenTreatment OutcomeConceptsChimeric antigen receptor (CAR) immunotherapyCAR immunotherapyCancer immunotherapyClinical outcomesImmune cellsImmunological synapseCancer therapyPrecision cancer immunotherapyRefractory blood cancersRecent clinical trialsTumor antigen specificityUnique cell surface receptorChimeric antigen receptorImmune cell activationAdoptive transferImmunotherapeutic strategiesSuppressor cellsClinical predictorsCell immunotherapyClinical trialsIndividual patientsImmunotherapyAntigen specificityCell activationBlood cancers
2015
Fine-Needle Aspiration Biopsy of Salivary Gland Lesions
Wang H, Fundakowski C, Khurana J, Jhala N. Fine-Needle Aspiration Biopsy of Salivary Gland Lesions. Archives Of Pathology & Laboratory Medicine 2015, 139: 1491-7. PMID: 26619021, DOI: 10.5858/arpa.2015-0222-ra.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, PleomorphicBiomarkers, TumorBiopsy, Fine-NeedleCarcinomaClinical Decision-MakingHumansSalivary Gland NeoplasmsSalivary GlandsConceptsFine-needle aspirationSalivary gland neoplasmsSalivary gland lesionsGland neoplasmsGland lesionsFNA samplesPersonal practice experiencePreoperative patient counselingNeedle aspiration biopsySalivary gland tumorsClinical decision makingSalivary gland fine-needle aspirationPatient counselingNovel classification systemImmunohistochemical markersAspiration biopsyGland tumorsMolecular pathogenesisNew classification systemDiagnostic approach
2014
Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy
JIANG H, WANG H, WANG S, PEI Z, FU Z, FANG C, WANG J, LU Q, WANG E, LI J. Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy. Molecular Medicine Reports 2014, 11: 3523-3532. PMID: 25573098, DOI: 10.3892/mmr.2014.3141.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma of LungAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorDNA-Binding ProteinsDrug Resistance, NeoplasmEndonucleasesFemaleGene ExpressionHumansImmunohistochemistryKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedMyoD ProteinMyoglobinMyosin Type IIPlatinumPleural Effusion, MalignantPrognosisRibonucleoside Diphosphate ReductaseThymidylate SynthaseTubulinTumor Suppressor ProteinsConceptsExcision repair cross-complementing gene 1Expression of ERCC1Platinum-based chemotherapyMetastatic lung adenocarcinomaLung adenocarcinomaPleural effusionLung Adenocarcinoma Pleural EffusionsPlatinum-based chemotherapy treatmentTumor cellsUntreated lung adenocarcinomasSurvival of patientsMalignant pleural effusionPleural fluid samplesExpression levelsProtein expression levelsWestern blot analysisClinical outcomesPatient survivalLung cancerChemotherapy treatmentLung carcinomaNon-muscle myosin IIPatientsAdenocarcinomaSurvival rateFollow-up of breast papillary lesion on core needle biopsy: experience in African-American population
Wang H, Tsang P, D’Cruz C, Clarke K. Follow-up of breast papillary lesion on core needle biopsy: experience in African-American population. Diagnostic Pathology 2014, 9: 86. PMID: 24762090, PMCID: PMC4039081, DOI: 10.1186/1746-1596-9-86.Peer-Reviewed Original ResearchConceptsCore needle biopsyBreast papillary lesionsIntraductal papillary carcinomaBenign papillary lesionsInvasive papillary carcinomaPapillary lesionsPapillary carcinomaNeedle biopsyAfrican American populationAfrican-American urban populationRate of upgradeAtypical papillary lesionsMalignant papillary lesionsLumpectomy/mastectomyResultsA totalPatient populationCore biopsyFollow-upEarly excisionAtypical lesionsLesion casesBiopsyCarcinomaLesionsLumpectomy
2012
Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway
Wang H, Chen Y, Castillo C, Yilmaz O, Deshpande V. Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway. Modern Pathology 2012, 26: 139-147. PMID: 22918166, DOI: 10.1038/modpathol.2012.143.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorHumansImmunohistochemistryIntestinal NeoplasmsNeuroendocrine TumorsOligonucleotide Array Sequence AnalysisPancreatic NeoplasmsReal-Time Polymerase Chain ReactionReceptors, NotchRectal NeoplasmsReverse Transcriptase Polymerase Chain ReactionSignal TransductionTissue Array AnalysisTranscriptomeConceptsRectal neuroendocrine tumorsGastroenteropancreatic neuroendocrine tumorsIleal neuroendocrine tumorsNeuroendocrine tumorsPancreatic neuroendocrine tumorsClinical trialsISL LIM homeobox 1Tryptophan hydroxylase 1Quantitative reverse transcription PCRReverse transcription-PCRGene profiling studiesNotch1 inhibitorTissue microarrayImmunohistochemical analysisMolecular pathogenesisTumorsLIM homeobox 1Endocrine pathwaysGene expression profilingGlobal gene expression profilingHomeobox 1Gene profiling resultsNotch1Further studiesProliferation pathways