2013
Altered vascular activation due to deficiency of the NADPH oxidase component p22phox
Wang H, Albadawi H, Siddiquee Z, Stone J, Panchenko M, Watkins M, Stone J. Altered vascular activation due to deficiency of the NADPH oxidase component p22phox. Cardiovascular Pathology 2013, 23: 35-42. PMID: 24035466, DOI: 10.1016/j.carpath.2013.08.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarotid Artery InjuriesCarotid Artery, CommonCase-Control StudiesCasein Kinase IalphaCells, CulturedCoronary VesselsCytochrome b GroupElastic TissueFemaleGranulomatous Disease, ChronicHeterogeneous-Nuclear Ribonucleoprotein Group CHumansHyperplasiaInfantMaleMatrix Metalloproteinase 12MiceMice, KnockoutMuscle, Smooth, VascularNADPH OxidasesNeointimaReactive Oxygen SpeciesRNA InterferenceTissue Inhibitor of Metalloproteinase-1TransfectionConceptsWild-type littermatesElastic fiber lossVascular activationDeficient miceIntimal hyperplasiaNADPH oxidase complexCoronary artery smooth muscle cellsNicotinamide adenine dinucleotide phosphate (NADPH) oxidaseArtery smooth muscle cellsHuman coronary artery smooth muscle cellsAdenine Dinucleotide Phosphate OxidaseBasal blood pressureCarotid artery ligationExpression ratioSmooth muscle cellsLung biopsyBlood pressureFiber lossArtery ligationCarotid ligationCarotid arteryTissue inhibitorHuman patientsMuscle cellsMice
2006
Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease
Zhao L, Grosser T, Fries S, Kadakia L, Wang H, Zhao J, Falotico R. Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease. Expert Review Of Clinical Immunology 2006, 2: 649-658. PMID: 20477620, DOI: 10.1586/1744666x.2.4.649.Peer-Reviewed Original ResearchCardiovascular diseaseCOX-2-derived prostaglandinsAortic aneurysm pathogenesisLow-density lipoprotein oxidationTh1 cytokine productionInflammatory chemokine productionInflammatory lipid mediatorsMonocyte-endothelial cell interactionsSelective inhibitionCertain cardiovascular diseasesHuman cardiovascular diseaseSystemic drug deliveryCardiovascular eventsChemokine productionCytokine productionBiosynthesis of leukotrienesDeficient miceCOX-2Murine modelLipoprotein oxidationLipid mediatorsMouse modelTherapeutic benefitCOX-1Aneurysm pathogenesis