2020
The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy
Liu D, Badeti S, Dotti G, Jiang JG, Wang H, Dermody J, Soteropoulos P, Streck D, Birge RB, Liu C. The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy. Cell Communication And Signaling 2020, 18: 134. PMID: 32843053, PMCID: PMC7446110, DOI: 10.1186/s12964-020-00617-7.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor (CAR) immunotherapyCAR immunotherapyCancer immunotherapyClinical outcomesImmune cellsImmunological synapseCancer therapyPrecision cancer immunotherapyRefractory blood cancersRecent clinical trialsTumor antigen specificityUnique cell surface receptorChimeric antigen receptorImmune cell activationAdoptive transferImmunotherapeutic strategiesSuppressor cellsClinical predictorsCell immunotherapyClinical trialsIndividual patientsImmunotherapyAntigen specificityCell activationBlood cancers
2012
Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway
Wang H, Chen Y, Castillo C, Yilmaz O, Deshpande V. Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway. Modern Pathology 2012, 26: 139-147. PMID: 22918166, DOI: 10.1038/modpathol.2012.143.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorHumansImmunohistochemistryIntestinal NeoplasmsNeuroendocrine TumorsOligonucleotide Array Sequence AnalysisPancreatic NeoplasmsReal-Time Polymerase Chain ReactionReceptors, NotchRectal NeoplasmsReverse Transcriptase Polymerase Chain ReactionSignal TransductionTissue Array AnalysisTranscriptomeConceptsRectal neuroendocrine tumorsGastroenteropancreatic neuroendocrine tumorsIleal neuroendocrine tumorsNeuroendocrine tumorsPancreatic neuroendocrine tumorsClinical trialsISL LIM homeobox 1Tryptophan hydroxylase 1Quantitative reverse transcription PCRReverse transcription-PCRGene profiling studiesNotch1 inhibitorTissue microarrayImmunohistochemical analysisMolecular pathogenesisTumorsLIM homeobox 1Endocrine pathwaysGene expression profilingGlobal gene expression profilingHomeobox 1Gene profiling resultsNotch1Further studiesProliferation pathways